In mdx mouse fetuses, the lack of dystrophin markedly impairs secondary myogenesis due to reduced muscle stem cell polarity. AAK1 deletion restores polarity and rescues secondary myogenesis, revealing...

Scientific discussion groups disseminate knowledge across laboratories, departments and institutions and create new connections across the community. Discussion groups are open to investigators, tr...

Peng et al. show that DLL1-expressing muscle myoblasts not only regulate NOTCH signaling in neighbor cells but also send a retrograde signal to themselves via the DLL1 intracellular domain.

Transcriptomics (bulk and single-nuclei RNAseq) and lipidomics (mass spectrometry) analysis showed that slow-twitch muscle (soleus) is enriched in bioactive lipids derived from docosahexaenoic acid (...

imageimageMuscle injury induces expression of myokines that promote muscle regeneration. This study identifies the fibronectin domain-containing protein FNDC1 as a myokine that promotes myogenesis and...

Endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) are activated in skeletal

Satellite cells are skeletal muscle stem cells that contribute to postnatal muscle growth, and they

The JAK/STAT pathway is a conserved metazoan signal transduction system with roles in regulating gro

This study introduces SiCP@InjGel, an injectable, bioactive hydrogel designed to address severe volumetric muscle loss (VML). Utilizing advanced multi-omics analysis, the authors demonstrate that SiCP@InjGel significantly modulates the immune microenvironment and enhances muscle regeneration across multiple animal models, including clinically relevant porcine models. By promoting M2 macrophage polarization and myogenic differentiation, this innovative biomaterial offers a promising, minimally invasive strategy for effectively repairing skeletal muscle defects, paving the way for clinical translation and improved patient outcomes.

Endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) are activated in skeletal