#MicroSplit
MicroSplit: Semantic Unmixing of Fluorescent Microscopy Data [new]
Enables computational multiplexing of fluorescence microscopy data. Separates superimposed noisy structures into distinct channels using deep learning.
February 11, 2025 at 4:03 PM
And as a bonus, #MicroSplit gets rid of noise in your micrographs. (“Input” and “Target” is what was imaged at the 🔬, the predictions are what MicroSplit hands you after seeing only the input.)

👇Here an example for unmixing two rather noisy structures👇
February 8, 2025 at 7:49 AM
Oh, and… did I mention you can also remove artifacts (ie., structured noise) from your data?

This #MicroSplit micro-🧵 is meant as a little teaser.
Full story (a massive collaborative effort with a ton of amazing people) will drop next week. 🤩
February 8, 2025 at 7:49 AM
An enormous "𝐭𝐡𝐚𝐧𝐤 𝐲𝐨𝐮" goes to the fantastic #MicroSplit team... covering contributions from hard-core method development, over research software engineering mastery, to lots and lots of dataset generation and fruitful discussions on results and possible ways to improve.

Thank you all! ❤️
February 11, 2025 at 6:08 PM
MicroSplit: Semantic Unmixing of Fluorescent Microscopy Data https://www.biorxiv.org/content/10.1101/2025.02.10.637323v1
February 11, 2025 at 3:47 PM
Amazing work by Ashesh, @florianjug.bsky.social, and the rest of the 𝑴𝒊𝒄𝒓𝒐𝕊𝒑𝒍𝒊𝒕 team. I have seen this work presented by Ashesh several times now, and it blows my mind each and every time. Check it out to take your imaging experiments to the next level!
🔬🎤 As pre-announced a few days ago... please let us proudly present to you: 𝑴𝒊𝒄𝒓𝒐𝕊𝒑𝒍𝒊𝒕 - your ticket to imaging more, imaging more gentle, and/or imaging more efficient. 🔬

doi.org/10.1101/2025...

Like ❤️, repost 🔂, and most importantly... please send feedback ✉️ our way! 🙏
February 11, 2025 at 8:09 PM
🔬🎤 As pre-announced a few days ago... please let us proudly present to you: 𝑴𝒊𝒄𝒓𝒐𝕊𝒑𝒍𝒊𝒕 - your ticket to imaging more, imaging more gentle, and/or imaging more efficient. 🔬

doi.org/10.1101/2025...

Like ❤️, repost 🔂, and most importantly... please send feedback ✉️ our way! 🙏
February 11, 2025 at 6:02 PM
March 25, 2025 at 4:27 AM
MicroSplit: Semantic Unmixing of Fluorescent Microscopy Data https://www.biorxiv.org/content/10.1101/2025.02.10.637323v1
February 11, 2025 at 3:47 PM
Immagine you could image two cellular structures in the same fluorescent channel and still reliably get them separated afterwards…
What would you do with this?

Now… what would you do if that also worked with 4 structures at once? 👇 #MicroSplit #preview🧵
February 8, 2025 at 7:49 AM