Comprehensive review explores C. glutamicum metabolic engineering for diverse biochemicals, challenges & future directions. #MetabolicEngineering #CellFactories
Details: doi.org/10.1016/j.bidere.2025.100008
Details: doi.org/10.1016/j.bidere.2025.100008
November 5, 2025 at 3:24 PM
Comprehensive review explores C. glutamicum metabolic engineering for diverse biochemicals, challenges & future directions. #MetabolicEngineering #CellFactories
Details: doi.org/10.1016/j.bidere.2025.100008
Details: doi.org/10.1016/j.bidere.2025.100008
Comprehensive review on C. glutamicum metabolic engineering for diverse substrates & biochemicals, challenges & future directions. #MetabolicEngineering #CellFactories #Corynebacterium
Details: doi.org/10.1016/j.bidere.2025.100008
Details: doi.org/10.1016/j.bidere.2025.100008
October 28, 2025 at 3:38 PM
Comprehensive review on C. glutamicum metabolic engineering for diverse substrates & biochemicals, challenges & future directions. #MetabolicEngineering #CellFactories #Corynebacterium
Details: doi.org/10.1016/j.bidere.2025.100008
Details: doi.org/10.1016/j.bidere.2025.100008
What is Synthetic Biology? A Guide to Engineering Life #livingmachines #geneticengineering #biologicalsystems #syntheticbiology #customDNA #bioengineering #designinglife #CRISPR #DNAsynthesis #metabolicengineering
What is Synthetic Biology? A Guide to Engineering Life
Imagine a world where we could program living cells the way we program computers. A world with bacteria that produce clean fuel from sunlight, yeasts that brew life-saving medicines instead…
jivoice.com
October 23, 2025 at 4:35 PM
What is Synthetic Biology? A Guide to Engineering Life #livingmachines #geneticengineering #biologicalsystems #syntheticbiology #customDNA #bioengineering #designinglife #CRISPR #DNAsynthesis #metabolicengineering
DeepGDel, a new deep‑learning framework, improves gene‑deletion design accuracy by up to 22.52% compared with traditional methods, aiding growth‑coupled strain engineering. Read more: https://getnews.me/deepgdel-deep-learning-enhances-gene-deletion-design/ #deepgdel #metabolicengineering
October 6, 2025 at 5:14 PM
DeepGDel, a new deep‑learning framework, improves gene‑deletion design accuracy by up to 22.52% compared with traditional methods, aiding growth‑coupled strain engineering. Read more: https://getnews.me/deepgdel-deep-learning-enhances-gene-deletion-design/ #deepgdel #metabolicengineering
New back cover out this week in @greenchemistry.rsc.org for Lahiru Jayakody et al. at SIU Carbondale. P. putida was engineered to efficiently convert caffeine to 7-MX, a compound for treating myopia.
#greenchemistry #metabolicengineering #biochemistry #microbiology #scientificillustration
#greenchemistry #metabolicengineering #biochemistry #microbiology #scientificillustration
September 26, 2025 at 10:43 AM
New back cover out this week in @greenchemistry.rsc.org for Lahiru Jayakody et al. at SIU Carbondale. P. putida was engineered to efficiently convert caffeine to 7-MX, a compound for treating myopia.
#greenchemistry #metabolicengineering #biochemistry #microbiology #scientificillustration
#greenchemistry #metabolicengineering #biochemistry #microbiology #scientificillustration
Yarrowia lipolytica boosts terpene synthesis via synthetic biology! #Biofuels #MetabolicEngineering
Details: doi.org/10.34133/bdr.0046
Details: doi.org/10.34133/bdr.0046
September 16, 2025 at 7:41 AM
Yarrowia lipolytica boosts terpene synthesis via synthetic biology! #Biofuels #MetabolicEngineering
Details: doi.org/10.34133/bdr.0046
Details: doi.org/10.34133/bdr.0046
Delighted to join #MetabolicEngineering as Associate Editor w/Sang Yup Lee, Jay Keasling, I. Borodina, C. Maranas & C. Wittmann. I'll handle submissions in #SyntheticMetabolism, #Pseudomonas, #SynBio, new-to-nature #bioproduction & #EnvironmentalBiotechnology!
September 2, 2025 at 4:50 PM
Delighted to join #MetabolicEngineering as Associate Editor w/Sang Yup Lee, Jay Keasling, I. Borodina, C. Maranas & C. Wittmann. I'll handle submissions in #SyntheticMetabolism, #Pseudomonas, #SynBio, new-to-nature #bioproduction & #EnvironmentalBiotechnology!
Corynebacterium glutamicum engineering advances for diverse biochemical production! #MetabolicEngineering
Details: doi.org/10.1016/j.bidere.2025.100008
Details: doi.org/10.1016/j.bidere.2025.100008
September 2, 2025 at 2:56 PM
Corynebacterium glutamicum engineering advances for diverse biochemical production! #MetabolicEngineering
Details: doi.org/10.1016/j.bidere.2025.100008
Details: doi.org/10.1016/j.bidere.2025.100008
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
doi.org/10.1038/s414...
#Genomics #Withanolides #SpecializedMetabolism #BiosyntheticGeneCluster #LongReadSequencing #MetabolicEngineering #OpenAccess #OpenData
doi.org/10.1038/s414...
#Genomics #Withanolides #SpecializedMetabolism #BiosyntheticGeneCluster #LongReadSequencing #MetabolicEngineering #OpenAccess #OpenData
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis - Nature Communications
Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown. Here, the authors report the g...
doi.org
July 26, 2025 at 10:34 PM
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
doi.org/10.1038/s414...
#Genomics #Withanolides #SpecializedMetabolism #BiosyntheticGeneCluster #LongReadSequencing #MetabolicEngineering #OpenAccess #OpenData
doi.org/10.1038/s414...
#Genomics #Withanolides #SpecializedMetabolism #BiosyntheticGeneCluster #LongReadSequencing #MetabolicEngineering #OpenAccess #OpenData
Implementing synthetic serine cycles in #Pseudomonas putida unlock methanol assimilation in our favorite bug w/carbon conservation, led by ÒscarPuiggené @labnikel.bsky.social · #SynBio #MetabolicEngineering #Methanol published in @cp-trendsbiotech.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Systematic engineering of synthetic serine cycles in Pseudomonas putida uncovers emergent topologies for methanol assimilation
The urgent need for a circular carbon economy has driven research into sustainable substrates, including one-carbon (C1) compounds. The non-pathogenic…
www.sciencedirect.com
July 7, 2025 at 4:09 PM
Implementing synthetic serine cycles in #Pseudomonas putida unlock methanol assimilation in our favorite bug w/carbon conservation, led by ÒscarPuiggené @labnikel.bsky.social · #SynBio #MetabolicEngineering #Methanol published in @cp-trendsbiotech.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
ALE & metabolic engineering boost SA production from glycerol in E. coli. Sustainable biodiesel byproduct utilization! #BiodieselByproducts #SAproduction #MetabolicEngineering
Details: doi.org/10.1016/j.bidere.2025.100022
Details: doi.org/10.1016/j.bidere.2025.100022
June 16, 2025 at 2:21 PM
ALE & metabolic engineering boost SA production from glycerol in E. coli. Sustainable biodiesel byproduct utilization! #BiodieselByproducts #SAproduction #MetabolicEngineering
Details: doi.org/10.1016/j.bidere.2025.100022
Details: doi.org/10.1016/j.bidere.2025.100022
C. glutamicum metabolic engineering expands substrates & products. Challenges & future directions explored! #CorynebacteriumGlutamicum #CellFactories #MetabolicEngineering
Details: doi.org/10.1016/j.bidere.2025.100008
Details: doi.org/10.1016/j.bidere.2025.100008
May 22, 2025 at 1:59 PM
C. glutamicum metabolic engineering expands substrates & products. Challenges & future directions explored! #CorynebacteriumGlutamicum #CellFactories #MetabolicEngineering
Details: doi.org/10.1016/j.bidere.2025.100008
Details: doi.org/10.1016/j.bidere.2025.100008
We evolved T. kivui to grow fast on CO (doubling time ~2.8 h). The trick? A megatransposon rewired its redox and metabolic circuits.
#Transposons: not just genetic noise, but engines of innovation!
Full story: doi.org/10.1038/s414...
#Biotechnology #Extremophiles #MetabolicEngineering
#Transposons: not just genetic noise, but engines of innovation!
Full story: doi.org/10.1038/s414...
#Biotechnology #Extremophiles #MetabolicEngineering
A megatransposon drives the adaptation of Thermoanaerobacter kivui to carbon monoxide - Nature Communications
Carbon monoxide (CO) present in syngas severely inhibits growth of many acetogens. Here, the authors adapt, characterize, and engineer utilization of CO as sole carbon and energy source by the thermop...
doi.org
May 14, 2025 at 8:56 AM
We evolved T. kivui to grow fast on CO (doubling time ~2.8 h). The trick? A megatransposon rewired its redox and metabolic circuits.
#Transposons: not just genetic noise, but engines of innovation!
Full story: doi.org/10.1038/s414...
#Biotechnology #Extremophiles #MetabolicEngineering
#Transposons: not just genetic noise, but engines of innovation!
Full story: doi.org/10.1038/s414...
#Biotechnology #Extremophiles #MetabolicEngineering
Our work opens the door to real #MetabolicEngineering in T. kivui.
It grows fast on CO₂ (∼2 h doubling time) with high carbon efficiency—ideal for sustainable fuel and chemical production.
With rapid, iterative genome editing now possible, these applications are within reach!
2/2
It grows fast on CO₂ (∼2 h doubling time) with high carbon efficiency—ideal for sustainable fuel and chemical production.
With rapid, iterative genome editing now possible, these applications are within reach!
2/2
May 12, 2025 at 7:33 AM
Our work opens the door to real #MetabolicEngineering in T. kivui.
It grows fast on CO₂ (∼2 h doubling time) with high carbon efficiency—ideal for sustainable fuel and chemical production.
With rapid, iterative genome editing now possible, these applications are within reach!
2/2
It grows fast on CO₂ (∼2 h doubling time) with high carbon efficiency—ideal for sustainable fuel and chemical production.
With rapid, iterative genome editing now possible, these applications are within reach!
2/2
The Nair lab is looking for a #post-doc experienced in yeast pathway and genome engineering. Please DM or email me if you are interested!! Please spread the word! #synbio #metabolicengineering
April 22, 2025 at 1:26 PM
The Nair lab is looking for a #post-doc experienced in yeast pathway and genome engineering. Please DM or email me if you are interested!! Please spread the word! #synbio #metabolicengineering
Our partners @w-u-r.bsky.social and @mpimicrobiomarburg.bsky.social demonstrated how synthetic metabolism can outperform the Calvin cycle—nature’s mechanism for CO2 fixation.
Read the full, open-access Nature Microbiology article at doi.org/10.1038/s415...
#SyntheticBiology #MetabolicEngineering
Read the full, open-access Nature Microbiology article at doi.org/10.1038/s415...
#SyntheticBiology #MetabolicEngineering
One-carbon fixation via the synthetic reductive glycine pathway exceeds yield of the Calvin cycle - Nature Microbiology
An engineered one-carbon-fixation pathway increases biomass yields of Cupriavidus necator compared with the Calvin cycle and can support future, sustainable bio-based production.
doi.org
March 28, 2025 at 2:04 PM
Our partners @w-u-r.bsky.social and @mpimicrobiomarburg.bsky.social demonstrated how synthetic metabolism can outperform the Calvin cycle—nature’s mechanism for CO2 fixation.
Read the full, open-access Nature Microbiology article at doi.org/10.1038/s415...
#SyntheticBiology #MetabolicEngineering
Read the full, open-access Nature Microbiology article at doi.org/10.1038/s415...
#SyntheticBiology #MetabolicEngineering
Featured today by @MSKLibrary: Metabolic engineering to facilitate anti-tumor immunity
#MetabolicEngineering #CancerImmunotherapy #TumorImmunity #BiomedicalResearch #PrecisionMedicine #ImmunoOncology #CancerMetabolism
www.sciencedirect.com/science/arti...
#MetabolicEngineering #CancerImmunotherapy #TumorImmunity #BiomedicalResearch #PrecisionMedicine #ImmunoOncology #CancerMetabolism
www.sciencedirect.com/science/arti...
March 19, 2025 at 4:14 PM
Featured today by @MSKLibrary: Metabolic engineering to facilitate anti-tumor immunity
#MetabolicEngineering #CancerImmunotherapy #TumorImmunity #BiomedicalResearch #PrecisionMedicine #ImmunoOncology #CancerMetabolism
www.sciencedirect.com/science/arti...
#MetabolicEngineering #CancerImmunotherapy #TumorImmunity #BiomedicalResearch #PrecisionMedicine #ImmunoOncology #CancerMetabolism
www.sciencedirect.com/science/arti...
And more #metabolicengineering for lignans biosynthesis #chembio
A yeast consortium capable of multicellular division of labor, similar to plants, is constructed for de novo synthesis of complex antiviral lignans
www.nature.com/articles/s41...
www.nature.com/articles/s41...
De novo biosynthesis of plant lignans by synthetic yeast consortia - Nature Chemical Biology
Reconstructing the biosynthesis of complex natural products in yeast is challenging. Here the authors construct a yeast consortium with obligate mutualism aiming to alleviate metabolic promiscuity thr...
www.nature.com
March 18, 2025 at 7:48 PM
And more #metabolicengineering for lignans biosynthesis #chembio
A nice #metabolicengineering for renewable plastics from Sang Yup Lee’s group
A paper in Nature Chemical Biology presents a system that uses E. coli bacteria to create biodegradable plastics. The system may help in the production of plastics with desirable thermal and mechanical properties, using renewable resources. https://go.nature.com/4hEOaGc 🧪
March 18, 2025 at 7:29 PM
A nice #metabolicengineering for renewable plastics from Sang Yup Lee’s group
..and fine tuning between endogenous activities and novel functions implemented by #metabolicengineering. A story - now available in preprint - brilliantly led by our Oscar! 💪
March 9, 2025 at 10:53 AM
..and fine tuning between endogenous activities and novel functions implemented by #metabolicengineering. A story - now available in preprint - brilliantly led by our Oscar! 💪
Another thesis paper post:
Engineering of a new platform strain of Z. mobilis for chemical production utilizing a metabolic flux valve.
We achieved specific productivity for lactate of > 90 mmol gCDW ^−1 h ^−1
#MetabolicEngineering #SynBio
doi.org/10.1186/s129...
Engineering of a new platform strain of Z. mobilis for chemical production utilizing a metabolic flux valve.
We achieved specific productivity for lactate of > 90 mmol gCDW ^−1 h ^−1
#MetabolicEngineering #SynBio
doi.org/10.1186/s129...
A new Zymomonas mobilis platform strain for the efficient production of chemicals - Microbial Cell Factories
Background Zymomonas mobilis is well known for its outstanding ability to produce ethanol with both high specific productivity and with high yield close to the theoretical maximum. The key enzyme in t...
doi.org
December 10, 2024 at 5:08 PM
Another thesis paper post:
Engineering of a new platform strain of Z. mobilis for chemical production utilizing a metabolic flux valve.
We achieved specific productivity for lactate of > 90 mmol gCDW ^−1 h ^−1
#MetabolicEngineering #SynBio
doi.org/10.1186/s129...
Engineering of a new platform strain of Z. mobilis for chemical production utilizing a metabolic flux valve.
We achieved specific productivity for lactate of > 90 mmol gCDW ^−1 h ^−1
#MetabolicEngineering #SynBio
doi.org/10.1186/s129...
Biocompatible chemistry has the potential to revolutionise the chemical industry by addressing many of the fundamental limitations of #OrganicChemistry, #Biocatalysis and #MetabolicEngineering
November 27, 2024 at 1:15 PM
Biocompatible chemistry has the potential to revolutionise the chemical industry by addressing many of the fundamental limitations of #OrganicChemistry, #Biocatalysis and #MetabolicEngineering
To the best of our knowledge, with the fnrF8 promoter we have engineered E. coli to reach the highest specific glucose uptake rate of 21.7 mmolGlc gDW−1 h−1 reported to date under anaerobic conditions in minimal medium during exponential growth. #MetabolicEngineering
November 25, 2024 at 3:31 PM
To the best of our knowledge, with the fnrF8 promoter we have engineered E. coli to reach the highest specific glucose uptake rate of 21.7 mmolGlc gDW−1 h−1 reported to date under anaerobic conditions in minimal medium during exponential growth. #MetabolicEngineering
Finishing up my thesis:
First appl. of Zymo-Parts in E. coli was a systematic characterization of 15 oxy.-dependent promoters! Tying het. gene expr. in 2-stage processes to shifts from aerobic biomass creation to production phase. #MetabolicEngineering #SynBio
www.sciencedirect.com/science/arti...
First appl. of Zymo-Parts in E. coli was a systematic characterization of 15 oxy.-dependent promoters! Tying het. gene expr. in 2-stage processes to shifts from aerobic biomass creation to production phase. #MetabolicEngineering #SynBio
www.sciencedirect.com/science/arti...
Characterizing and utilizing oxygen-dependent promoters for efficient dynamic metabolic engineering
Promoters adjust cellular gene expression in response to internal or external signals and are key elements for implementing dynamic metabolic engineer…
www.sciencedirect.com
November 25, 2024 at 3:03 PM
Finishing up my thesis:
First appl. of Zymo-Parts in E. coli was a systematic characterization of 15 oxy.-dependent promoters! Tying het. gene expr. in 2-stage processes to shifts from aerobic biomass creation to production phase. #MetabolicEngineering #SynBio
www.sciencedirect.com/science/arti...
First appl. of Zymo-Parts in E. coli was a systematic characterization of 15 oxy.-dependent promoters! Tying het. gene expr. in 2-stage processes to shifts from aerobic biomass creation to production phase. #MetabolicEngineering #SynBio
www.sciencedirect.com/science/arti...
Just published!Building on our previous work on the serine-glycine-one carbon metabolic network (Rosa-Téllez et al.2024),we’ve now engineered this network to boost nitrogen in crops #PlantScience #ClimateResilience #MetabolicEngineering #SustainableAgriculture onlinelibrary.wiley.com/doi/10.1111/...
Metabolic engineering of the serine/glycine network as a means to improve the nitrogen content of crops
In plants, L-serine (Ser) biosynthesis occurs through various pathways and is highly dependent on the atmospheric CO2 concentration, especially in C3 species, due to the association of the Glycolate ....
onlinelibrary.wiley.com
November 16, 2024 at 12:00 PM
Just published!Building on our previous work on the serine-glycine-one carbon metabolic network (Rosa-Téllez et al.2024),we’ve now engineered this network to boost nitrogen in crops #PlantScience #ClimateResilience #MetabolicEngineering #SustainableAgriculture onlinelibrary.wiley.com/doi/10.1111/...