Even the above pyramid overplays metaanalysis /systemic reviews, because it depends entirely on what is being reviewed and the study design / weightings / (in some cases, outright "hot takes") of the SR. E.g. a crappy metastudy of cohort studies pales in relevance to a single good RCT.
November 11, 2025 at 2:52 PM
Even the above pyramid overplays metaanalysis /systemic reviews, because it depends entirely on what is being reviewed and the study design / weightings / (in some cases, outright "hot takes") of the SR. E.g. a crappy metastudy of cohort studies pales in relevance to a single good RCT.
i read a metaanalysis on porn addiction studies and indeed there is no solid ground to describe and diagnose porn addiction, since addiction is a severe narcological-psychiatric disorder. BUT there is comorbidity with unhealthy porn consumption and having a psychiatric disorder. OCD for example.
November 11, 2025 at 6:47 AM
i read a metaanalysis on porn addiction studies and indeed there is no solid ground to describe and diagnose porn addiction, since addiction is a severe narcological-psychiatric disorder. BUT there is comorbidity with unhealthy porn consumption and having a psychiatric disorder. OCD for example.
Metaanalysis of IAV in dogs and cats: 12.04 % in dogs and 1.73 % in cats. Seroprevalence was 12.07 % in dogs and 7.39 % in cats. Higher prevalence in the Americas and Asia compared to Europe. No info on subtype?
👉 www.sciencedirect.com/science/arti...
👉 www.sciencedirect.com/science/arti...
November 11, 2025 at 6:43 AM
Metaanalysis of IAV in dogs and cats: 12.04 % in dogs and 1.73 % in cats. Seroprevalence was 12.07 % in dogs and 7.39 % in cats. Higher prevalence in the Americas and Asia compared to Europe. No info on subtype?
👉 www.sciencedirect.com/science/arti...
👉 www.sciencedirect.com/science/arti...
#MetaAnalysis (>1.5M individuals) shows 1 in 4 #IBD patients have NAFLD—higher in adults, males, and Western regions.
Highlights need for routine liver screening in IBD management. #epidemiology #prevalence academic.oup.com/ibdjournal/a...
Highlights need for routine liver screening in IBD management. #epidemiology #prevalence academic.oup.com/ibdjournal/a...
Prevalence and Associated Factors of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease: An Updated Global Systematic Review and Meta-Analysis of over 1.5 Million Individuals
AbstractBackground. Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver condition worldwide, with its burden increasingly
academic.oup.com
November 10, 2025 at 5:38 AM
#MetaAnalysis (>1.5M individuals) shows 1 in 4 #IBD patients have NAFLD—higher in adults, males, and Western regions.
Highlights need for routine liver screening in IBD management. #epidemiology #prevalence academic.oup.com/ibdjournal/a...
Highlights need for routine liver screening in IBD management. #epidemiology #prevalence academic.oup.com/ibdjournal/a...
🌿 Herbs for bones? Our meta-analysis of 48 trials shows medicinal plants reduce bone loss & boost formation. A natural step toward osteoporosis care! 🔗 doi.org/10.1016/j.ja... #BoneHealth #HerbalMedicine #Osteoporosis #MetaAnalysis #MedicinalPlants #TPM
November 9, 2025 at 8:35 AM
🌿 Herbs for bones? Our meta-analysis of 48 trials shows medicinal plants reduce bone loss & boost formation. A natural step toward osteoporosis care! 🔗 doi.org/10.1016/j.ja... #BoneHealth #HerbalMedicine #Osteoporosis #MetaAnalysis #MedicinalPlants #TPM
i have yet to see a single metaanalysis that supports the serotonin theory of depression but "you're depressed because of a chemical imbalance" is a perfect thought-terminating cliche for people who want to invoke the language of science without understanding it.
November 5, 2025 at 10:58 PM
i have yet to see a single metaanalysis that supports the serotonin theory of depression but "you're depressed because of a chemical imbalance" is a perfect thought-terminating cliche for people who want to invoke the language of science without understanding it.
New Book Review: "Systematic Reviews to Support Evidence-Based Medicine 3rd Edition" by @crcpress
www.jlo.co.uk/book-review/...
#EBM #MetaAnalysis #Epidemiology #ScholarLife #SystematicReviews
www.jlo.co.uk/book-review/...
#EBM #MetaAnalysis #Epidemiology #ScholarLife #SystematicReviews
Systematic Reviews to Support Evidence-Based Medicine 3rd Edition - The Journal of Laryngology & Otology
Review by L Flood Middlesbrough, UK I tried to get this book to review when it first emerged in 2023, as I have a great interest in systematic reviews. I am surely an expert, as I am charged by this j...
www.jlo.co.uk
November 5, 2025 at 9:49 PM
New Book Review: "Systematic Reviews to Support Evidence-Based Medicine 3rd Edition" by @crcpress
www.jlo.co.uk/book-review/...
#EBM #MetaAnalysis #Epidemiology #ScholarLife #SystematicReviews
www.jlo.co.uk/book-review/...
#EBM #MetaAnalysis #Epidemiology #ScholarLife #SystematicReviews
#statstab #452 Assumption Checking Prevents Assumption Hacking in Multiverse Meta-Analyses
Thoughts: Heterogeneity, publication bias, multiverse analysis, z-curve and more.
#zcurve #multiverse #heterogeneity #metaanalysis #bias #publicationbias
replicationindex.com/2025/06/13/a...
Thoughts: Heterogeneity, publication bias, multiverse analysis, z-curve and more.
#zcurve #multiverse #heterogeneity #metaanalysis #bias #publicationbias
replicationindex.com/2025/06/13/a...
Assumption Checking Prevents Assumption Hacking in Multiverse Meta-Analyses - Replicability-Index
In a nutshell Statistical methods for meta-analyses make different assumptions. For this reason, different methods can produce different results with the same data. Meta-analysts often struggle to mak...
replicationindex.com
November 4, 2025 at 6:16 PM
#statstab #452 Assumption Checking Prevents Assumption Hacking in Multiverse Meta-Analyses
Thoughts: Heterogeneity, publication bias, multiverse analysis, z-curve and more.
#zcurve #multiverse #heterogeneity #metaanalysis #bias #publicationbias
replicationindex.com/2025/06/13/a...
Thoughts: Heterogeneity, publication bias, multiverse analysis, z-curve and more.
#zcurve #multiverse #heterogeneity #metaanalysis #bias #publicationbias
replicationindex.com/2025/06/13/a...
🧵 [2/6]
🔬 33 RCTs, 12,028 participants: combining GLP-1RAs with lifestyle changes = -7.13 kg weight loss!
🌐 #MetaAnalysis #WeightLoss #INPST @castltrastondrs.bsky.social @heatherpics1.bsky.social @oleksandrkashuba.bsky.social @rachel-garcia.bsky.social @gmpinglish.bsky.social
🔬 33 RCTs, 12,028 participants: combining GLP-1RAs with lifestyle changes = -7.13 kg weight loss!
🌐 #MetaAnalysis #WeightLoss #INPST @castltrastondrs.bsky.social @heatherpics1.bsky.social @oleksandrkashuba.bsky.social @rachel-garcia.bsky.social @gmpinglish.bsky.social
November 4, 2025 at 12:02 PM
🧵 [2/6]
🔬 33 RCTs, 12,028 participants: combining GLP-1RAs with lifestyle changes = -7.13 kg weight loss!
🌐 #MetaAnalysis #WeightLoss #INPST @castltrastondrs.bsky.social @heatherpics1.bsky.social @oleksandrkashuba.bsky.social @rachel-garcia.bsky.social @gmpinglish.bsky.social
🔬 33 RCTs, 12,028 participants: combining GLP-1RAs with lifestyle changes = -7.13 kg weight loss!
🌐 #MetaAnalysis #WeightLoss #INPST @castltrastondrs.bsky.social @heatherpics1.bsky.social @oleksandrkashuba.bsky.social @rachel-garcia.bsky.social @gmpinglish.bsky.social
To address this, we conducted a pre-registered #systematicreview and #metaanalysis of experiments testing Green Nest Material’s effect on avian fitness proxies 🐦
We synthesised 274 effect sizes from 28 studies on 7 species across 17 regions
📄 doi.org/10.32942/X2X...
We synthesised 274 effect sizes from 28 studies on 7 species across 17 regions
📄 doi.org/10.32942/X2X...
November 3, 2025 at 7:29 AM
To address this, we conducted a pre-registered #systematicreview and #metaanalysis of experiments testing Green Nest Material’s effect on avian fitness proxies 🐦
We synthesised 274 effect sizes from 28 studies on 7 species across 17 regions
📄 doi.org/10.32942/X2X...
We synthesised 274 effect sizes from 28 studies on 7 species across 17 regions
📄 doi.org/10.32942/X2X...
Just published #MetaAnalysis of #AdverseEffects of short-course #steroids in #children and #adolescents in many diseases can provide high certainty evidence for their use in #RareDisease. Generally applicable approach for harms of common drugs in rare diseases.
pubmed.ncbi.nlm.nih.gov/41026484/
pubmed.ncbi.nlm.nih.gov/41026484/
Adverse Events Following Short-Course Systemic Corticosteroids Among Children and Adolescents: A Systematic Review and Meta-Analysis - PubMed
In this systematic review and meta-analysis of randomized trials, there was moderate certainty evidence that corticosteroids were associated with an increased risk of hyperglycemia and sleep problems and low certainty evidence that corticosteroids were associated with increased risk of gastrointesti …
pubmed.ncbi.nlm.nih.gov
November 3, 2025 at 4:24 AM
Just published #MetaAnalysis of #AdverseEffects of short-course #steroids in #children and #adolescents in many diseases can provide high certainty evidence for their use in #RareDisease. Generally applicable approach for harms of common drugs in rare diseases.
pubmed.ncbi.nlm.nih.gov/41026484/
pubmed.ncbi.nlm.nih.gov/41026484/
Amazing. Someone points out that the results of nudge metaanalysis are actually all publication bias. Original authors then brush it off with ”[being] a relatively young field … comes with some methodological growing pains.”
there have been big questions raised about the quality and reliability of the research suggesting that small nudges (like moving an entry field or asking people to tick a box) meaningfully affect behaviour
No evidence for nudging after adjusting for publication bias | PNAS
No evidence for nudging after adjusting for publication bias
www.pnas.org
November 2, 2025 at 11:26 AM
Amazing. Someone points out that the results of nudge metaanalysis are actually all publication bias. Original authors then brush it off with ”[being] a relatively young field … comes with some methodological growing pains.”
#MetaAnalysis of 158 studies: #BiologicalValves fail more over time; mechanical ones need fewer reoperations but cause more thrombosis. Mortality low for both. #CHD #PVR link.springer.com/article/10.1....
Long-Term Outcomes and Complications of Pulmonary Valve Replacement: A Meta-Analysis of Mechanical Versus Biological Prostheses - Pediatric Cardiology
This meta-analysis exclusively examines pulmonary valve replacement (PVR) outcomes in congenital heart disease (CHD) patients. CHD affects nearly 1% of live births globally, with a significant subset ...
link.springer.com
November 1, 2025 at 8:11 AM
#MetaAnalysis of 158 studies: #BiologicalValves fail more over time; mechanical ones need fewer reoperations but cause more thrombosis. Mortality low for both. #CHD #PVR link.springer.com/article/10.1....
Adding anti-angiogenesis therapy to PD-1/PD-L1 + chemo improves PFS and ORR in ES-SCLC, especially in patients under 65. No OS benefit overall. Safety comparable.
🔗 buff.ly/tMshYDZ
#LungCancer #CheckpointInhibitors #MetaAnalysis
🔗 buff.ly/tMshYDZ
#LungCancer #CheckpointInhibitors #MetaAnalysis
Efficacy and safety of first-line PD-1/PD-L1 inhibitors combined with or without anti-angiogenesis therapy for extensive-stage small-cell lung cancer: a network meta-analysis - Linjing Zhou, Yuwei Li, Le Wang, Kaiyan Chen, Shichao Zhou, Yunfei Chen, Jing Sun, Yunfeng Tong, Yun Fan, 2025
Background: Immune checkpoint inhibitors (ICIs) combined with chemotherapy, with or without angiogenesis inhibitors, have been investigated as the first-line tr...
doi.org
October 31, 2025 at 7:15 AM
Adding anti-angiogenesis therapy to PD-1/PD-L1 + chemo improves PFS and ORR in ES-SCLC, especially in patients under 65. No OS benefit overall. Safety comparable.
🔗 buff.ly/tMshYDZ
#LungCancer #CheckpointInhibitors #MetaAnalysis
🔗 buff.ly/tMshYDZ
#LungCancer #CheckpointInhibitors #MetaAnalysis
Higher Systemic Immune-Inflammation Index is associated with non-alcoholic fatty liver disease; Hedge’s g = 0.11 and odds ratio (OR) = 1.45. Further longitudinal studies are needed. #NAFLD #SII #SystemicInflammation #Biomarker #MetaAnalysis journals.lww.com/annals-of-me...
October 30, 2025 at 5:19 AM
Higher Systemic Immune-Inflammation Index is associated with non-alcoholic fatty liver disease; Hedge’s g = 0.11 and odds ratio (OR) = 1.45. Further longitudinal studies are needed. #NAFLD #SII #SystemicInflammation #Biomarker #MetaAnalysis journals.lww.com/annals-of-me...
#statstab #448 {metaforest} Small sample meta-analysis
Thoughts: "a machine-learning based, exploratory approach to identify relevant moderators in meta-analysis"
#ML #MachineLearning #metaanalysis #smallsample #samplesize #heterogeneity #moderator
cjvanlissa.github.io/metaforest/a...
Thoughts: "a machine-learning based, exploratory approach to identify relevant moderators in meta-analysis"
#ML #MachineLearning #metaanalysis #smallsample #samplesize #heterogeneity #moderator
cjvanlissa.github.io/metaforest/a...
Introduction to metaforest
cjvanlissa.github.io
October 29, 2025 at 6:24 PM
#statstab #448 {metaforest} Small sample meta-analysis
Thoughts: "a machine-learning based, exploratory approach to identify relevant moderators in meta-analysis"
#ML #MachineLearning #metaanalysis #smallsample #samplesize #heterogeneity #moderator
cjvanlissa.github.io/metaforest/a...
Thoughts: "a machine-learning based, exploratory approach to identify relevant moderators in meta-analysis"
#ML #MachineLearning #metaanalysis #smallsample #samplesize #heterogeneity #moderator
cjvanlissa.github.io/metaforest/a...
New from #Transfusion Evidence Library:
#Metaanalysis of the safety and efficacy of fresh frozen plasma exchange in the treatment of organophosphate pesticide poisoning
by Cai et al.
www.transfusionevidencelibrary.com/alerts/artic...
#MedSky
#Metaanalysis of the safety and efficacy of fresh frozen plasma exchange in the treatment of organophosphate pesticide poisoning
by Cai et al.
www.transfusionevidencelibrary.com/alerts/artic...
#MedSky
October 28, 2025 at 11:04 AM
New from #Transfusion Evidence Library:
#Metaanalysis of the safety and efficacy of fresh frozen plasma exchange in the treatment of organophosphate pesticide poisoning
by Cai et al.
www.transfusionevidencelibrary.com/alerts/artic...
#MedSky
#Metaanalysis of the safety and efficacy of fresh frozen plasma exchange in the treatment of organophosphate pesticide poisoning
by Cai et al.
www.transfusionevidencelibrary.com/alerts/artic...
#MedSky
Oral antihypertensive Rx during pregnancy:
systematic review & network #metaanalysis
❓methyldopa vs labetalol vs nifedipine vs placebo/no Rx
@acog.org @drklindley.bsky.social @minnowwalsh.bsky.social @abraguo.bsky.social
#CardioObstetrics #ACCRepOB #ACCCardioOB
www.ajog.org/article/S000...
systematic review & network #metaanalysis
❓methyldopa vs labetalol vs nifedipine vs placebo/no Rx
@acog.org @drklindley.bsky.social @minnowwalsh.bsky.social @abraguo.bsky.social
#CardioObstetrics #ACCRepOB #ACCCardioOB
www.ajog.org/article/S000...
October 27, 2025 at 5:02 PM
Oral antihypertensive Rx during pregnancy:
systematic review & network #metaanalysis
❓methyldopa vs labetalol vs nifedipine vs placebo/no Rx
@acog.org @drklindley.bsky.social @minnowwalsh.bsky.social @abraguo.bsky.social
#CardioObstetrics #ACCRepOB #ACCCardioOB
www.ajog.org/article/S000...
systematic review & network #metaanalysis
❓methyldopa vs labetalol vs nifedipine vs placebo/no Rx
@acog.org @drklindley.bsky.social @minnowwalsh.bsky.social @abraguo.bsky.social
#CardioObstetrics #ACCRepOB #ACCCardioOB
www.ajog.org/article/S000...
From the #Transfusion Evidence Alert:
Restrictive vs. Liberal Transfusion Strategy in Critically Ill Patients with Acute Brain Injury: A #SystematicReview and #Metaanalysis
by Boutrik et al.
www.transfusionevidencelibrary.com/alerts/artic...
#MedSky
Restrictive vs. Liberal Transfusion Strategy in Critically Ill Patients with Acute Brain Injury: A #SystematicReview and #Metaanalysis
by Boutrik et al.
www.transfusionevidencelibrary.com/alerts/artic...
#MedSky
October 27, 2025 at 7:00 AM
From the #Transfusion Evidence Alert:
Restrictive vs. Liberal Transfusion Strategy in Critically Ill Patients with Acute Brain Injury: A #SystematicReview and #Metaanalysis
by Boutrik et al.
www.transfusionevidencelibrary.com/alerts/artic...
#MedSky
Restrictive vs. Liberal Transfusion Strategy in Critically Ill Patients with Acute Brain Injury: A #SystematicReview and #Metaanalysis
by Boutrik et al.
www.transfusionevidencelibrary.com/alerts/artic...
#MedSky
Dynapenic obesity—defined by either #BMI or waist circumference—significantly increases all-cause mortality risk (HR up to 1.73).
Our findings highlight the compounded impact of muscle weakness and #obesity on long-term survival. #MuscleStrength #MetaAnalysis link.springer.com/article/10.1...
Our findings highlight the compounded impact of muscle weakness and #obesity on long-term survival. #MuscleStrength #MetaAnalysis link.springer.com/article/10.1...
Dynapenic obesity and all-Cause mortality: A systematic review and Meta-analysis of prospective cohort studies - Aging Clinical and Experimental Research
Background Dynapenia and obesity have been independently shown to be associated with an increased risk of all-cause mortality. However, the association between dynapenic obesity [defined by waist circ...
link.springer.com
October 27, 2025 at 5:52 AM
Dynapenic obesity—defined by either #BMI or waist circumference—significantly increases all-cause mortality risk (HR up to 1.73).
Our findings highlight the compounded impact of muscle weakness and #obesity on long-term survival. #MuscleStrength #MetaAnalysis link.springer.com/article/10.1...
Our findings highlight the compounded impact of muscle weakness and #obesity on long-term survival. #MuscleStrength #MetaAnalysis link.springer.com/article/10.1...
🚨 ICYMI - Diagnostic test accuracy #MetaAnalysis methods
View the recording:
ti.ubc.ca/2023/05/17/d...
#ResearchMethods #NetworkMetaAnalysis
View the recording:
ti.ubc.ca/2023/05/17/d...
#ResearchMethods #NetworkMetaAnalysis
Dr. Veroniki and Dr. Tsokani: Diagnostic test accuracy network meta-analysis methods
YouTube video by Therapeutics Initiative
www.youtube.com
October 26, 2025 at 8:51 PM
🚨 ICYMI - Diagnostic test accuracy #MetaAnalysis methods
View the recording:
ti.ubc.ca/2023/05/17/d...
#ResearchMethods #NetworkMetaAnalysis
View the recording:
ti.ubc.ca/2023/05/17/d...
#ResearchMethods #NetworkMetaAnalysis
Stakeholders need to be involved in setting practice guidelines. They can't be with an opaque model doing metaanalysis. Models do not currently do RoB and pooling, but are expected to be able to in the future. They'll need access to everything, not just the OA subset, but could work with local PDFs.
October 20, 2025 at 5:53 PM
Stakeholders need to be involved in setting practice guidelines. They can't be with an opaque model doing metaanalysis. Models do not currently do RoB and pooling, but are expected to be able to in the future. They'll need access to everything, not just the OA subset, but could work with local PDFs.
What: Webinar on trial sequential analysis (TSA) in meta-analyses
When: 28 Oct 2025 13:00 to 13:45 (CEST)
Where: syddanskuni.zoom.us/j/61110310530
Christian Gunge Riberholt, associate professor at the University of Copenhagen, will talk about TSA and the potential errors of using it.
#MetaAnalysis
When: 28 Oct 2025 13:00 to 13:45 (CEST)
Where: syddanskuni.zoom.us/j/61110310530
Christian Gunge Riberholt, associate professor at the University of Copenhagen, will talk about TSA and the potential errors of using it.
#MetaAnalysis
October 20, 2025 at 11:40 AM
What: Webinar on trial sequential analysis (TSA) in meta-analyses
When: 28 Oct 2025 13:00 to 13:45 (CEST)
Where: syddanskuni.zoom.us/j/61110310530
Christian Gunge Riberholt, associate professor at the University of Copenhagen, will talk about TSA and the potential errors of using it.
#MetaAnalysis
When: 28 Oct 2025 13:00 to 13:45 (CEST)
Where: syddanskuni.zoom.us/j/61110310530
Christian Gunge Riberholt, associate professor at the University of Copenhagen, will talk about TSA and the potential errors of using it.
#MetaAnalysis
#MetaAnalysis (11 RCTs, n=12,730): #Colchicine shows no cardiovascular benefit in acute coronary syndrome (ACS), though safety remains acceptable. @fadyiskander.bsky.social bmccardiovascdisord.biomedcentral.com/articles/10....
Efficacy and safety of colchicine in patients with acute coronary syndrome: a systematic review and meta-analysis of randomized controlled trials - BMC Cardiovascular Disorders
Background The European Society of Cardiology (ESC) recently endorsed low-dose colchicine for chronic coronary syndrome. However, its role in acute coronary syndrome (ACS) remains uncertain due to inc...
bmccardiovascdisord.biomedcentral.com
October 18, 2025 at 6:23 AM
#MetaAnalysis (11 RCTs, n=12,730): #Colchicine shows no cardiovascular benefit in acute coronary syndrome (ACS), though safety remains acceptable. @fadyiskander.bsky.social bmccardiovascdisord.biomedcentral.com/articles/10....