#LeonardiEffect
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scicom.bsky.social
Auf X/BlueSky liest man: Jede weitere COVID-Infektion zerstöre das Immunsystem – der sogenannte „Leonardi-Effekt“.

Das klingt dramatisch. 😱

❌Es gibt jedoch keine wissenschaftliche Evidenz, dass SARS-CoV-2 bei der Allgemeinbevölkerung das Immunsystem schrittweise schädigt. 🧵1/15 #LeonardiEffect
November 8, 2025 at 9:05 AM
beansproutsmom.bsky.social
One person brings a 'cold' into a room

1) where everyone else has 'normal' immune systems

2) where many occupants have weaker immune systems.

Guess what, we are ALL in Room 2 now, thanks to COVID.

What happens? We ALL get more exposures & infections.

#FUBAR #LeonardiEffect
October 9, 2025 at 3:53 PM
andreastudiescovid.bsky.social
The #Leonardieffect.
dlingenfelter.bsky.social David Lingenfelter, PhD @dlingenfelter.bsky.social · Sep 11
SARS-CoV-2 accelerates immune aging by shrinking T-cell diversity and telomeres, increasing risks for Long COVID, infections, and cancer.

It leaves lasting damage, especially in older or immunocompromised individuals.
davidlingenfelter.substack.com/p/accelerate...
🧬 Scientific Announcement Title: SARS-CoV-2 as a Catalyst of Accelerated Immunosenescence: New Insights into T-Cell Remodeling, Telomere Attrition, and Long-Term Clinical Risk I am pleased to announce the release of a comprehensive new analysis exploring the profound immunological consequences of SARS-CoV-2 infection. This work synthesizes cutting-edge data on T-cell repertoire contraction, telomere dynamics, and the emergence of persistent immune dysregulation, offering a paradigm-shifting view of COVID-19 as a potent accelerator of immune aging. 🔬 Key Findings: T-Cell Remodeling: SARS-CoV-2 infection induces a lasting contraction of the naïve T-cell pool and a skewed repertoire dominated by exhausted and senescent clones. Telomere Shortening: Immune cells from COVID-19 survivors exhibit significant telomere attrition, correlating with disease severity and persisting long after recovery. Long COVID Mechanisms: Persistent antigenic stimulation and dysregulated T-cell polarization contribute to chronic inflammation, autoimmunity, and immune exhaustion. Clinical Sequelae: Post-infection immunosenescence is linked to increased susceptibility to opportunistic infections, viral reactivations, and potentially heightened cancer risk. Therapeutic Horizons: Emerging geroprotective strategies—including senolytics and metformin—offer promising avenues to mitigate long-term immune dysfunction. 🧠 Implications: This report reframes COVID-19 not merely as an acute viral illness but as a biologically aging event with durable immunological consequences. It calls for a re-evaluation of public health strategies, emphasizing the need for long-term surveillance, immune-aging biomarkers, and host-resilience therapies. 📘 Access the Full Report: Read the full analysis on My Substack.
September 11, 2025 at 9:39 PM
marcveld.bsky.social
The #LeonardiEffect is being a dangerous clown, spreading nonsense without sufficient understanding of the subject, and crying foul when caught out again and again. But continuing to claim being right with more desperate sources every time, bc actually your are totally wrong.
7/7
August 3, 2025 at 10:32 PM
marcveld.bsky.social
#LeonardiEffect is like Calimero: "They are big and I is small: it is not fair!"

Poor Antony was a Med student? Or ... he had long finished his PhD with a first publication in 2012? Nevermind the antics.

What is his new wonderful evidence?
1/7
August 3, 2025 at 10:31 PM
andreastudiescovid.bsky.social
Good to see you post here, Anthony! When I first read your posts in early 2020 (sadly I'd already been infected once) I realized that COVID was a serious disease and one I never wanted to get again. And I have not, thanks to you and your #Leonardieffect lessons!
November 6, 2025 at 3:55 AM
christinavirgil.bsky.social
So with all of these infectious diseases popping up all over the world, and zoonotic spillover occurring, some may have difficulty understanding what’s happening. The analogy I came up with that I find most useful is pictured below.

Many refer to it as the #LeonardiEffect
I have explained it like this: all of these infectious pathogens are like white noise, but our immune systems easily ignored it. But with the population-wide dampening of immunity, it’s like the volume on the white noise is turned up and it impacts us then.
September 20, 2023 at 1:22 PM
adelaidehillslife.bsky.social
Not "just a cold". #leonardieffect in action... 😷
October 8, 2025 at 11:37 PM
realitycheckmarker.bsky.social
"Flow cytometry was performed 15 weeks after the patient experienced mild COVID-19"

"lymphopenia was documented in populations CD3+CD4+, CD3+CD8+, and CD3−CD16+CD56+"

#PASC #SAND #LongCOVID #LeonardiEffect #AirborneAIDS #Incurable

frontiersin.org/articles/10.33…
November 25, 2024 at 5:03 PM
marcveld.bsky.social
The #LeonardiEffect strikes again. When you lack knowledge and follow a cult: you misinterpret words and studies, thereby claiming nonsense and causing unnecessary concern.
1/2
November 8, 2025 at 8:16 AM
marcveld.bsky.social
2) SC2 does not broadly activate T cells. T cells activated are SC2-specific, SC2 does not have any super antigens.

3) We have very good vaccines. Pharmacological treatments are few for viruses which has been a large problem for a very long time.

#LeonardiEffect
2/3
September 14, 2025 at 7:46 AM
marcveld.bsky.social
She converted back from the cult? A scientist that fell for the #LeonardiEffect: made up pseudoscience, twisting scientific literature.
August 25, 2025 at 6:53 PM
marcveld.bsky.social
The grifter is at it again, with his pseudoscience nonsense. The paper refered to shows dormant tumour cells can awaken due to inflammatory mediators. Influenza and SC2 are used to cause inflammation in mice.

He didn't read or understand #LeonardiEffect

August 29, 2025 at 7:17 PM
marcveld.bsky.social
Ah, someone did like this paper?
He likely did not even read it but copied in/used AI to echo the authors´ conclusions and took them at face value.

He is correct about one thing: these bad papers could be refered to as #LeonardiEffect.

July 28, 2025 at 4:07 PM
christinavirgil.bsky.social
#LeonardiEffect
November 26, 2024 at 9:55 PM
marcveld.bsky.social
Indeed this is the #LeonardiEffect. Non-experts who don't understand scientific literature and context, making up outlandish BS scare stories for clicks, thereby endangering people. Here two players who frequently do this.

September 5, 2025 at 11:53 AM
realitycheckmarker.bsky.social
~ SARS Epidemic ~
Situation update for China for week of: March 23

#ZeroCOVID #Azvudine #PASC #SAND #LongCOVID #LeonardiEffect #AirborneAIDS #Incurable
🧵

chinacdc.cn/jkzt/crb/zl/sz…
November 25, 2024 at 5:04 PM
andreastudiescovid.bsky.social
And this phenomenon is called, still, the #LeonardiEffect.
June 13, 2025 at 2:21 AM
andreastudiescovid.bsky.social
The #LeonardiEffect continues to be proven.
June 13, 2025 at 2:23 AM
marcveld.bsky.social
This behaviour, abusing science without knowledge to defend an ideology is also known as the #Leonardi_Effect or #LeonardiEffect. It is spreading medical disinformation, by ideology, ignoring all data and knowledge available, but constantly claiming "I told you so".
2/2
October 30, 2025 at 8:32 PM
drinfosec.bsky.social
And here's the sub🧵 by Dr. @harryspoelstra.bsky.social (on Twitter):

threadreaderapp.com/thread/19683...
Study of Peripheral Blood T-Lymphocytes and Their Subpopulations in COVID-19 Patients ‼️Fascinating Chinees study(60 patients, December 2022 and March 2023) and there we go……#LeonardiEffect @fitterhappierAJ ➡️"In summary, SARS-CoV-2 infection has a significant effect on the number of T-lymphocytes and the ratio of their subpopulations, especially in critically ill and elderly patients, suggesting that SARS-CoV-2 infection severely affects the cellular immune function of the organism." ➡️"We found that the absolute counts of T-lymphocytes and their subpopulations in the peripheral blood of patients with COVID-19 are
September 19, 2025 at 1:40 AM