I said no more #LISSSD25 posts but forgot a major highlight!
Most sessions started w/ a patient lived experience video, and you can see them all @ lisssd2025.org/patient-stories
Looking after patients during thier illnesses is v. stressful so it's great to hear their experiences when recovered.
Most sessions started w/ a patient lived experience video, and you can see them all @ lisssd2025.org/patient-stories
Looking after patients during thier illnesses is v. stressful so it's great to hear their experiences when recovered.
Patient Stories — LISSSD 2025
www.lisssd2025.org
June 5, 2025 at 7:33 AM
I said no more #LISSSD25 posts but forgot a major highlight!
Most sessions started w/ a patient lived experience video, and you can see them all @ lisssd2025.org/patient-stories
Looking after patients during thier illnesses is v. stressful so it's great to hear their experiences when recovered.
Most sessions started w/ a patient lived experience video, and you can see them all @ lisssd2025.org/patient-stories
Looking after patients during thier illnesses is v. stressful so it's great to hear their experiences when recovered.
Prof M Good & A/Prof M Pandey close #LISSSD25 thanking all the local committee, scientific advisory committee (led by Dr
T Lamagni & @joshosowicki.bsky.social), presenters, and delegates.
Prof A Steer announces #LISSSD28 is to be held in
📌 Limassol, Cyprus 🇨🇾 2028
T Lamagni & @joshosowicki.bsky.social), presenters, and delegates.
Prof A Steer announces #LISSSD28 is to be held in
📌 Limassol, Cyprus 🇨🇾 2028
June 5, 2025 at 4:20 AM
Prof M Good & A/Prof M Pandey close #LISSSD25 thanking all the local committee, scientific advisory committee (led by Dr
T Lamagni & @joshosowicki.bsky.social), presenters, and delegates.
Prof A Steer announces #LISSSD28 is to be held in
📌 Limassol, Cyprus 🇨🇾 2028
T Lamagni & @joshosowicki.bsky.social), presenters, and delegates.
Prof A Steer announces #LISSSD28 is to be held in
📌 Limassol, Cyprus 🇨🇾 2028
Last of the #LISSSD25 presentations is Prof Victor Nizet imploring the community to think like streptococci in these times of authoritarianism USA anti-science
🍇 Evade host immunity (cont to do work)
🍇 Form biofilms (network)
🍇 Colonise diverse hosts (expand skill sets)
#strep #idsky
🍇 Evade host immunity (cont to do work)
🍇 Form biofilms (network)
🍇 Colonise diverse hosts (expand skill sets)
#strep #idsky
June 5, 2025 at 4:04 AM
Prof M Voysey presents some prelim results of a prospective GBS infect. cohort
🧮 101 early & 67 late iGBS vs 286 GBS colonised but not infected ctrl
🚼 Birth weight of late < early < ctrl
3️⃣ Serotype III most common, esp in late onset dis.
#LISSSD25 #gbs #clinmicro
🧮 101 early & 67 late iGBS vs 286 GBS colonised but not infected ctrl
🚼 Birth weight of late < early < ctrl
3️⃣ Serotype III most common, esp in late onset dis.
#LISSSD25 #gbs #clinmicro
June 5, 2025 at 3:53 AM
Prof M Voysey presents some prelim results of a prospective GBS infect. cohort
🧮 101 early & 67 late iGBS vs 286 GBS colonised but not infected ctrl
🚼 Birth weight of late < early < ctrl
3️⃣ Serotype III most common, esp in late onset dis.
#LISSSD25 #gbs #clinmicro
🧮 101 early & 67 late iGBS vs 286 GBS colonised but not infected ctrl
🚼 Birth weight of late < early < ctrl
3️⃣ Serotype III most common, esp in late onset dis.
#LISSSD25 #gbs #clinmicro
Dr K Gibney flys the flag for 🦘 clin trials by 🎺
ISAAC 🔎 at Abx prophylaxis of close iGAS contacts (enrolling soon)
STRAP 🔎 backbone Abx, adjunctive Abx, and IVIg (enrolling 2026ish)
Only enrolling in Aus for now but looking for int. collab.
#LISSSD25 #idsky #clinicaltrials #strep
ISAAC 🔎 at Abx prophylaxis of close iGAS contacts (enrolling soon)
STRAP 🔎 backbone Abx, adjunctive Abx, and IVIg (enrolling 2026ish)
Only enrolling in Aus for now but looking for int. collab.
#LISSSD25 #idsky #clinicaltrials #strep
June 5, 2025 at 1:24 AM
Dr K Gibney flys the flag for 🦘 clin trials by 🎺
ISAAC 🔎 at Abx prophylaxis of close iGAS contacts (enrolling soon)
STRAP 🔎 backbone Abx, adjunctive Abx, and IVIg (enrolling 2026ish)
Only enrolling in Aus for now but looking for int. collab.
#LISSSD25 #idsky #clinicaltrials #strep
ISAAC 🔎 at Abx prophylaxis of close iGAS contacts (enrolling soon)
STRAP 🔎 backbone Abx, adjunctive Abx, and IVIg (enrolling 2026ish)
Only enrolling in Aus for now but looking for int. collab.
#LISSSD25 #idsky #clinicaltrials #strep
Dr O Xie has an entertaining talk on S. dys subsp eq [SDSE]
🐴 iSDSE has similar incidence and mortality v iGAS
🐎 Less genomic clustering in SDSE
🫏 Global dissemination iSDSE driven by stG62647-lineage
#LISSSD25 #clinmicro #idsky
🐴 iSDSE has similar incidence and mortality v iGAS
🐎 Less genomic clustering in SDSE
🫏 Global dissemination iSDSE driven by stG62647-lineage
#LISSSD25 #clinmicro #idsky
June 5, 2025 at 12:59 AM
Dr O Xie has an entertaining talk on S. dys subsp eq [SDSE]
🐴 iSDSE has similar incidence and mortality v iGAS
🐎 Less genomic clustering in SDSE
🫏 Global dissemination iSDSE driven by stG62647-lineage
#LISSSD25 #clinmicro #idsky
🐴 iSDSE has similar incidence and mortality v iGAS
🐎 Less genomic clustering in SDSE
🫏 Global dissemination iSDSE driven by stG62647-lineage
#LISSSD25 #clinmicro #idsky
PhD cand. J Iwasaki talks about mechanism behind strep throat recurrence.
👅 ~15% strep throat relapse
👅 Relapse strains can persist in ⬆️ [pen]
👅 Intracellular persistence in strep intracell. comm. [SIC]
👅 SICs are L-switch'd to lack cell wall hence recur post Pen Rx
#LISSSD25 #clinmicro
👅 ~15% strep throat relapse
👅 Relapse strains can persist in ⬆️ [pen]
👅 Intracellular persistence in strep intracell. comm. [SIC]
👅 SICs are L-switch'd to lack cell wall hence recur post Pen Rx
#LISSSD25 #clinmicro
June 4, 2025 at 5:47 AM
PhD cand. J Iwasaki talks about mechanism behind strep throat recurrence.
👅 ~15% strep throat relapse
👅 Relapse strains can persist in ⬆️ [pen]
👅 Intracellular persistence in strep intracell. comm. [SIC]
👅 SICs are L-switch'd to lack cell wall hence recur post Pen Rx
#LISSSD25 #clinmicro
👅 ~15% strep throat relapse
👅 Relapse strains can persist in ⬆️ [pen]
👅 Intracellular persistence in strep intracell. comm. [SIC]
👅 SICs are L-switch'd to lack cell wall hence recur post Pen Rx
#LISSSD25 #clinmicro
It’s my great pleasure to present the Global Pneumoocccal Sequencing project at #LISSSD25
I feel humbled to learn more about Group A and Group B streptococci and other species, and meet great minds to discuss science.
#GPS_project
I feel humbled to learn more about Group A and Group B streptococci and other species, and meet great minds to discuss science.
#GPS_project
June 4, 2025 at 4:11 AM
It’s my great pleasure to present the Global Pneumoocccal Sequencing project at #LISSSD25
I feel humbled to learn more about Group A and Group B streptococci and other species, and meet great minds to discuss science.
#GPS_project
I feel humbled to learn more about Group A and Group B streptococci and other species, and meet great minds to discuss science.
#GPS_project
Another AUROC: L Carlton presents a possible ARF biomarker id'd from a series of bead array exp using START cohort samples.
Most accurate candidate TRAFIP with AUROC 0.79 solo or upto 0.845 in combo w/ other biomarkers.
Coming to a revised-revised Jones criteria? #LISSSD25 #idsky
Most accurate candidate TRAFIP with AUROC 0.79 solo or upto 0.845 in combo w/ other biomarkers.
Coming to a revised-revised Jones criteria? #LISSSD25 #idsky
June 4, 2025 at 3:13 AM
Dr Dorota Jamrozy presents a well-powered GWAS to identify genetic features associated with invasive #GBS disease as compared with carriage at #LISSSD25
Thanks to the >20,000 GBS genomes in the #JUNO_project funded by @gatesfoundation.bsky.social
Thanks to the >20,000 GBS genomes in the #JUNO_project funded by @gatesfoundation.bsky.social
June 4, 2025 at 2:11 AM
Dr Dorota Jamrozy presents a well-powered GWAS to identify genetic features associated with invasive #GBS disease as compared with carriage at #LISSSD25
Thanks to the >20,000 GBS genomes in the #JUNO_project funded by @gatesfoundation.bsky.social
Thanks to the >20,000 GBS genomes in the #JUNO_project funded by @gatesfoundation.bsky.social
Prof N Ketheesan outlines his labs use of the Lewis rat model to explore RHD/ARF.
🐀 rM5 protein induces carditis & myocarditis, PR sensitive test
🐀 Sera & Tcells transfused to nin-exposed replicate disease.
🐀 Repeated exposures result in RHD phenotype w/ varied ab response.
#LISSSD25
🐀 rM5 protein induces carditis & myocarditis, PR sensitive test
🐀 Sera & Tcells transfused to nin-exposed replicate disease.
🐀 Repeated exposures result in RHD phenotype w/ varied ab response.
#LISSSD25
June 4, 2025 at 1:17 AM
Prof N Ketheesan outlines his labs use of the Lewis rat model to explore RHD/ARF.
🐀 rM5 protein induces carditis & myocarditis, PR sensitive test
🐀 Sera & Tcells transfused to nin-exposed replicate disease.
🐀 Repeated exposures result in RHD phenotype w/ varied ab response.
#LISSSD25
🐀 rM5 protein induces carditis & myocarditis, PR sensitive test
🐀 Sera & Tcells transfused to nin-exposed replicate disease.
🐀 Repeated exposures result in RHD phenotype w/ varied ab response.
#LISSSD25
Prof N Moreland from NZ speaks through the ARF perturbed immune response in ARF.
🌍 All strep A serotypes assoc w/ ARF in NZ
🌍 Increased IgG3 ab phenotpes
🌍 Immune infiltration valves incl plasma cells.
🌍 DIifferences in immue activation in acute & chronic RHD
#LISSSD25
🌍 All strep A serotypes assoc w/ ARF in NZ
🌍 Increased IgG3 ab phenotpes
🌍 Immune infiltration valves incl plasma cells.
🌍 DIifferences in immue activation in acute & chronic RHD
#LISSSD25
June 4, 2025 at 1:09 AM
Prof N Moreland from NZ speaks through the ARF perturbed immune response in ARF.
🌍 All strep A serotypes assoc w/ ARF in NZ
🌍 Increased IgG3 ab phenotpes
🌍 Immune infiltration valves incl plasma cells.
🌍 DIifferences in immue activation in acute & chronic RHD
#LISSSD25
🌍 All strep A serotypes assoc w/ ARF in NZ
🌍 Increased IgG3 ab phenotpes
🌍 Immune infiltration valves incl plasma cells.
🌍 DIifferences in immue activation in acute & chronic RHD
#LISSSD25
The first author Dr Akuzike Kalizang'oma presented this yesterday in the poster sessions at #LISSSD25. Interesting data! I wasn't so sure of the hypothesized link between the MDA and reduced vaccine efficacy but a pretty interesting story.
June 3, 2025 at 9:57 AM
The first author Dr Akuzike Kalizang'oma presented this yesterday in the poster sessions at #LISSSD25. Interesting data! I wasn't so sure of the hypothesized link between the MDA and reduced vaccine efficacy but a pretty interesting story.
@earmitage.bsky.social leverages the SpyCATS platform to investigate WASH facilities on Strep A infection incidence
⬇️ w/ handwashing, freq. clothes changing, good wound care, access to soap.
Limited by no wealth data & small sub-group but options for interventions identified.
#LISSSD25
⬇️ w/ handwashing, freq. clothes changing, good wound care, access to soap.
Limited by no wealth data & small sub-group but options for interventions identified.
#LISSSD25
June 3, 2025 at 3:02 AM
@earmitage.bsky.social leverages the SpyCATS platform to investigate WASH facilities on Strep A infection incidence
⬇️ w/ handwashing, freq. clothes changing, good wound care, access to soap.
Limited by no wealth data & small sub-group but options for interventions identified.
#LISSSD25
⬇️ w/ handwashing, freq. clothes changing, good wound care, access to soap.
Limited by no wealth data & small sub-group but options for interventions identified.
#LISSSD25
Dr K Doran presents interactions between C alb & GBS in the vaginal tract w/ some nifty models and clinical datasets
🦠 GBS & C alb increased in vaginal dysbiosis
🦠 C alb forms biofilm & GBS colonises
🦠 In the biofilm GBS is more antibiotic resistant & virulent (CovR)
#LISSSD25 #clinmicro
🦠 GBS & C alb increased in vaginal dysbiosis
🦠 C alb forms biofilm & GBS colonises
🦠 In the biofilm GBS is more antibiotic resistant & virulent (CovR)
#LISSSD25 #clinmicro
June 3, 2025 at 1:53 AM
Dr K Doran presents interactions between C alb & GBS in the vaginal tract w/ some nifty models and clinical datasets
🦠 GBS & C alb increased in vaginal dysbiosis
🦠 C alb forms biofilm & GBS colonises
🦠 In the biofilm GBS is more antibiotic resistant & virulent (CovR)
#LISSSD25 #clinmicro
🦠 GBS & C alb increased in vaginal dysbiosis
🦠 C alb forms biofilm & GBS colonises
🦠 In the biofilm GBS is more antibiotic resistant & virulent (CovR)
#LISSSD25 #clinmicro
A/Prof A Anderson talks about her qualitative research into Strep A vaccination
🗝️ 80x rates of ARF in some NZ groups
🗝️ ARF viewed as ongoing effect of colonisation
🗝️ Strep A vac a good thing (even 4 prochoice)
🗝️ Whanau (family) centric approach for consent and delivery
#LISSSD25 #idsky #strepA
🗝️ 80x rates of ARF in some NZ groups
🗝️ ARF viewed as ongoing effect of colonisation
🗝️ Strep A vac a good thing (even 4 prochoice)
🗝️ Whanau (family) centric approach for consent and delivery
#LISSSD25 #idsky #strepA
June 2, 2025 at 5:12 AM
Prof A Steer speaks about the progress to a Strep A vaccine, and highlights the current Emm and non-emm candidates as well as the challenges in Strep A. Steer highlights new human challenge models, published trial complication guidelines and monitoring, and building momenum. #LISSSD25 #idsky
June 2, 2025 at 4:11 AM
Prof de Silva & Dr Keeley speak on Strep A epi & immunity in the Gambia.
🗝️ Hyperendemicity of Strep A
🗝️ Index infections not explained by household contacts
🗝️ Early life immunity develops <2 y/o
🗝️ Ab response to carriage & infection
🗝️ ?protective immunity from SLO, SpyAD, SpyCEP
#LISSSD25 #IDsky
🗝️ Hyperendemicity of Strep A
🗝️ Index infections not explained by household contacts
🗝️ Early life immunity develops <2 y/o
🗝️ Ab response to carriage & infection
🗝️ ?protective immunity from SLO, SpyAD, SpyCEP
#LISSSD25 #IDsky
June 2, 2025 at 3:50 AM
Dr K Brown speaks about developing and validating an AI model for interpretation of non expert handheld parasternal images for DX of MR for RHD which had good sens (0.82) & spec (0.82) for LMIC setting. Also implementation study found it highly acceptable for staff & patients. #LISSSD25 #RHD
June 2, 2025 at 2:07 AM