Background: Internet hospitals and Internet + #nursing service have recently emerged as new medical and #nursing care models, respectively. Both use Internet-based information platforms and combine online applications and offline services to provide appropriate services. The rapid growth in the number of Internet hospitals in China has given rise to the Internet hospital plus home #nursing service model. Research on this new model is limited, and the effectiveness of its implementation remains to be clarified. Objective: We sought to examine the effectiveness of Internet hospital plus home #nursing model implementation by investigating workload volume, patients’ satisfaction, and #nurses’ perceptions to provide a strategic reference for Internet hospital plus home #nursing development. Methods: Data of patients who applied for Internet hospital plus home #nursing were collected from a hospital database. We analyzed the frequency of patients’ applications and the timeliness of Internet hospital plus home #nursing using chi-squared tests. We used a frequency table to assess the classification of patients’ illnesses, service items, and geographic distribution. An image visualization method was used to display patients’ regional distribution. Finally, we compared the cost of transferring patients to hospital for #nursing services with the cost of Internet hospital plus home #nursing using a simulation technique, Mann-Whitney U test and explore associations between characteristic factors and costs using multiple linear regression. Patients’ satisfaction at different stages was compared using a U-test. #nurses’ attitudes and suggestions regarding The Internet hospital plus home #nursing was examined with a questionnaire survey. Results: Medical records from 2459 Internet hospital plus home #nursing patients were examined. Most Internet hospital plus home #nursing patients were over 60 years old (2120/2459, 86.2%). The number of Internet hospital plus home #nursing applications differed significantly between age groups (24=29.86, P