#WeekendRead! #InterferonFriendOrFoe!
@benjbroom.bsky.social @groomlab.bsky.social &co show @jem.org that transient type I IFN inhibition upon LCMV infection or a mRNA vaccine boosts stem-like memory CD8 T cells by altering their location within the draining lymph node, potentiating virus protection
@benjbroom.bsky.social @groomlab.bsky.social &co show @jem.org that transient type I IFN inhibition upon LCMV infection or a mRNA vaccine boosts stem-like memory CD8 T cells by altering their location within the draining lymph node, potentiating virus protection
Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection | Journal of Experimental Medicine | Rockefeller University Press
Broomfield et al. demonstrate that early type I interferon blockade alters CXCR3 chemokine regulation and cell location to promote an antigen-dependent CD8
rupress.org
March 15, 2025 at 3:03 PM
#WeekendRead! #InterferonFriendOrFoe!
@benjbroom.bsky.social @groomlab.bsky.social &co show @jem.org that transient type I IFN inhibition upon LCMV infection or a mRNA vaccine boosts stem-like memory CD8 T cells by altering their location within the draining lymph node, potentiating virus protection
@benjbroom.bsky.social @groomlab.bsky.social &co show @jem.org that transient type I IFN inhibition upon LCMV infection or a mRNA vaccine boosts stem-like memory CD8 T cells by altering their location within the draining lymph node, potentiating virus protection
#interferonFriendorFoe ? So happy to have hosted my friend @boulantlab.bsky.social today at @ciml.bsky.social , showing nice new data on how basal #IFN lambda is essential for tight junction formation in epithelial cells! Very nice work from him and @meganstanifer.bsky.social
Today, we had the pleasure of welcoming Dr. Steeve Boulant from the University of Florida, as part of the 2025 CIML seminar series. Steeve gave a great talk on "Type III Interferons: from regulation of antiviral response to promoting barrier function". Thanks @boulantlab.bsky.social for your visit!
March 11, 2025 at 4:27 PM
#interferonFriendorFoe ? So happy to have hosted my friend @boulantlab.bsky.social today at @ciml.bsky.social , showing nice new data on how basal #IFN lambda is essential for tight junction formation in epithelial cells! Very nice work from him and @meganstanifer.bsky.social
#WeekendRead! #InterferonFriendOrFoe?! Ding, Hou &co show @co-cellhostmicrobe.bsky.social that rota & reovirus induce diarrhea (in neonate mice) via MAVS-IFN lambda downregulating a ion exchanger! IFNL is increased in human IBD biopsies as we also recently showed👉 doi.org/10.1016/j.cell.2024.10.010
March 9, 2025 at 4:56 PM
#WeekendRead! #InterferonFriendOrFoe?! Ding, Hou &co show @co-cellhostmicrobe.bsky.social that rota & reovirus induce diarrhea (in neonate mice) via MAVS-IFN lambda downregulating a ion exchanger! IFNL is increased in human IBD biopsies as we also recently showed👉 doi.org/10.1016/j.cell.2024.10.010
#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity
ZBP1 and mitochondrial Z-DNA drive autoimmune photosensitivity via cGAS-STING activation.
www.science.org
March 7, 2025 at 10:32 PM
#InterferonFriendOrFoe?! Klein @kahlenberglab.bsky.social &co show Science Immunology that UV drives mitochondrial Z-DNA to induce type I & III IFNs in keratinocytes. IFN-I upregulates ZBP1 that binds Z-DNA activating cGAS-STING to boost IFNs, photosensitivity & inflammation in #Lupus skin!
#InterferonFriendOrFoe?! Joe Sun, Xiaoqin Wei &co show @science.org that lung macrophage peroxisomes instruct repair programs after virus infections favoring AT2 cell renewal & recovery! IFNgamma drives pexophagy, increasing mitochondrial ROS & activating inflammasomes driving KRT8 cells & fibrosis!
Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae
Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolutio...
www.science.org
March 6, 2025 at 7:48 PM
#InterferonFriendOrFoe?! Joe Sun, Xiaoqin Wei &co show @science.org that lung macrophage peroxisomes instruct repair programs after virus infections favoring AT2 cell renewal & recovery! IFNgamma drives pexophagy, increasing mitochondrial ROS & activating inflammasomes driving KRT8 cells & fibrosis!