It’s just fake Internet hyperpolarization of the original opinion, which was begging craft breweries to make anything in another style before their slightly different 18th IPA. Really an early 2010s relic because that’s not the scene anymore. Anyone still saying that is sealioning hardcore.
November 11, 2025 at 7:04 PM
It’s just fake Internet hyperpolarization of the original opinion, which was begging craft breweries to make anything in another style before their slightly different 18th IPA. Really an early 2010s relic because that’s not the scene anymore. Anyone still saying that is sealioning hardcore.
the problem with the nationalized political environment and hyperpolarization is that there is little to no consequence for bad shit beyond a single term
no party has been able to restore a political regime in the style of reagan or FDR, to use a APD term
no party has been able to restore a political regime in the style of reagan or FDR, to use a APD term
"Watergate was so bad it locked Republicans out of power for a single election cycle."
November 10, 2025 at 3:25 PM
the problem with the nationalized political environment and hyperpolarization is that there is little to no consequence for bad shit beyond a single term
no party has been able to restore a political regime in the style of reagan or FDR, to use a APD term
no party has been able to restore a political regime in the style of reagan or FDR, to use a APD term
Loren L. Smith, Warren S. Warren: Non-resonant SABRE provides a new and versatile hyperpolarization approach for magnetic resonance https://arxiv.org/abs/2511.04851 https://arxiv.org/pdf/2511.04851 https://arxiv.org/html/2511.04851
November 10, 2025 at 6:46 AM
Loren L. Smith, Warren S. Warren: Non-resonant SABRE provides a new and versatile hyperpolarization approach for magnetic resonance https://arxiv.org/abs/2511.04851 https://arxiv.org/pdf/2511.04851 https://arxiv.org/html/2511.04851
It’s been online for a while already, but I’m sharing it here anyway: "Quantitative Trace Analysis of Dilute Mixtures Using a Benchtop NMR System with SABRE Hyperpolarization" by Bono Jimmink and Mattia Negroni #HISCORE pubs.acs.org/doi/10.1021/...
Quantitative Trace Analysis of Dilute Mixtures Using a Benchtop NMR System with SABRE Hyperpolarization
Despite their modest sensitivity, benchtop NMR spectrometers have recently attracted a great deal of attention, because of their low cost, high portability, and robustness. A solution to the sensitivity limitation of benchtop spectrometers is offered by nuclear spin hyperpolarization, by which large NMR signal enhancements can be realized. Signal Amplification By Reversible Exchange (SABRE) is one-such hyperpolarization technique, which utilizes hydrogen enriched in the para spin-isomer (pH2). However, the application of SABRE with benchtop NMR has so far largely been restricted to sample concentrations in the millimolar range. In this work, we present SABRE hyperpolarization of a mixture at micromolar concentrations, measured on a 1 T benchtop spectrometer. The observed linear dependence between hyperpolarized signals and concentration demonstrates the stability of our approach, which allows quantification in the micromolar range.
pubs.acs.org
November 8, 2025 at 8:49 PM
It’s been online for a while already, but I’m sharing it here anyway: "Quantitative Trace Analysis of Dilute Mixtures Using a Benchtop NMR System with SABRE Hyperpolarization" by Bono Jimmink and Mattia Negroni #HISCORE pubs.acs.org/doi/10.1021/...
J. Phys. Chem. Lett. 77Se Hyperpolarization Enabled by Reversible Parahydrogen Exchange and Audio-Frequency Magnetic Fields at 0.1 mT, Danil A. Markelov*, Alexey S. Kiryutin, Alexander V. Borisov, Irina D. Kosenko, Ivan A. Godovikov, Alexandra V. Yurkovskaya* pubs.acs.org/doi/10.1021/... #NMRchat 🧲
77Se Hyperpolarization Enabled by Reversible Parahydrogen Exchange and Audio-Frequency Magnetic Fields at 0.1 mT
Nuclear spin hyperpolarization boosts NMR sensitivity but typically requires complex infrastructure. Signal Amplification by Reversible Exchange (SABRE), a parahydrogen-based hyperpolarization techniq...
pubs.acs.org
November 5, 2025 at 3:34 PM
J. Phys. Chem. Lett. 77Se Hyperpolarization Enabled by Reversible Parahydrogen Exchange and Audio-Frequency Magnetic Fields at 0.1 mT, Danil A. Markelov*, Alexey S. Kiryutin, Alexander V. Borisov, Irina D. Kosenko, Ivan A. Godovikov, Alexandra V. Yurkovskaya* pubs.acs.org/doi/10.1021/... #NMRchat 🧲
J. Phys. Chem. Lett. 77Se Hyperpolarization Enabled by Reversible Parahydrogen Exchange and Audio-Frequency Magnetic Fields at 0.1 mT, Danil A. Markelov*, Alexey S. Kiryutin, Alexander V. Borisov, Irina D. Kosenko, Ivan A. Godovikov, Alexandra V. Yurkovskaya* pubs.acs.org/doi/10.1021/... #NMRchat 🧲
77Se Hyperpolarization Enabled by Reversible Parahydrogen Exchange and Audio-Frequency Magnetic Fields at 0.1 mT
Nuclear spin hyperpolarization boosts NMR sensitivity but typically requires complex infrastructure. Signal Amplification by Reversible Exchange (SABRE), a parahydrogen-based hyperpolarization techniq...
pubs.acs.org
November 5, 2025 at 3:33 PM
J. Phys. Chem. Lett. 77Se Hyperpolarization Enabled by Reversible Parahydrogen Exchange and Audio-Frequency Magnetic Fields at 0.1 mT, Danil A. Markelov*, Alexey S. Kiryutin, Alexander V. Borisov, Irina D. Kosenko, Ivan A. Godovikov, Alexandra V. Yurkovskaya* pubs.acs.org/doi/10.1021/... #NMRchat 🧲
Fresh from PERM 2025 ! Video Demonstration of 15N and 77Se Hyperpolarization at 50 μT via an Acoustic Audio Generator (mp4 video, 200 Mb) pubs.acs.org/doi/suppl/10... #NMRchat 🧲 source: pubs.acs.org/doi/10.1021/...
November 5, 2025 at 3:31 PM
Fresh from PERM 2025 ! Video Demonstration of 15N and 77Se Hyperpolarization at 50 μT via an Acoustic Audio Generator (mp4 video, 200 Mb) pubs.acs.org/doi/suppl/10... #NMRchat 🧲 source: pubs.acs.org/doi/10.1021/...
The first #congress member I'm interviewing with is in the top 10% most #bipartisan members of Congress...in this era of #hyperpolarization that's a great sign of getting sh** done. (I'll give you a wild guess who's dead ass last in #bipartisanship... hint: from #Ohio 😂)
November 4, 2025 at 8:19 PM
The first #congress member I'm interviewing with is in the top 10% most #bipartisan members of Congress...in this era of #hyperpolarization that's a great sign of getting sh** done. (I'll give you a wild guess who's dead ass last in #bipartisanship... hint: from #Ohio 😂)
‘A second set of channels (voltage-gated potassium and hyperpolarization-activated) regulated the timing of this rebound. In contrast, another channel (GIRK) interacted with inhibitory dopamine (D2) and GABA (GABAB) receptors to prevent rebound bursting.’
www.jneurosci.org/content/45/4...
www.jneurosci.org/content/45/4...
This Week in The Journal
Exploring a Dopamine Neuron and Striatal Circuit
Strahinja Stojanovic, Christopher Joseph Knowlton, Richard Egger-Mackrodt, Johanna Mankel, Josef Shin et al.
(see article e0361252025)
Dopamine neu...
www.jneurosci.org
October 29, 2025 at 9:52 PM
‘A second set of channels (voltage-gated potassium and hyperpolarization-activated) regulated the timing of this rebound. In contrast, another channel (GIRK) interacted with inhibitory dopamine (D2) and GABA (GABAB) receptors to prevent rebound bursting.’
www.jneurosci.org/content/45/4...
www.jneurosci.org/content/45/4...
This mitigates polarization loss during the transfer from the polarizer to the scanner, enabling the use of previously unsuitable, fast-relaxing molecules. The researchers demonstrated a 15N hyperpolarization of nearly 30% for 1-15N-nicotinamide using this method.
October 26, 2025 at 7:27 PM
This mitigates polarization loss during the transfer from the polarizer to the scanner, enabling the use of previously unsuitable, fast-relaxing molecules. The researchers demonstrated a 15N hyperpolarization of nearly 30% for 1-15N-nicotinamide using this method.
Breakthrough discovery: Chemically slowing nuclear spin relaxation preserves hyperpolarization, unlocking new possibilities for metabolic MRI with fast-relaxing molecules.
🧵 Thread below
Full analysis: https://helixbrief.com/article/5071bdcf-ac48-4974-8ebd-188daf7c6ebe
🧵 Thread below
Full analysis: https://helixbrief.com/article/5071bdcf-ac48-4974-8ebd-188daf7c6ebe
October 26, 2025 at 7:27 PM
Breakthrough discovery: Chemically slowing nuclear spin relaxation preserves hyperpolarization, unlocking new possibilities for metabolic MRI with fast-relaxing molecules.
🧵 Thread below
Full analysis: https://helixbrief.com/article/5071bdcf-ac48-4974-8ebd-188daf7c6ebe
🧵 Thread below
Full analysis: https://helixbrief.com/article/5071bdcf-ac48-4974-8ebd-188daf7c6ebe
#NMRchat Enhancing NMR Signals in Liquids by Fluorine‐19 Overhauser Dynamic Nuclear Polarization (DNP) and Hyperpolarization Transfer to Carbon‐13 https://onlinelibrary.wiley.com/doi/10.1002/anie.202517498?af=R
October 24, 2025 at 12:29 PM
#NMRchat Enhancing NMR Signals in Liquids by Fluorine‐19 Overhauser Dynamic Nuclear Polarization (DNP) and Hyperpolarization Transfer to Carbon‐13 https://onlinelibrary.wiley.com/doi/10.1002/anie.202517498?af=R
of the other feel so great that some citizens acquiesce to the weakening of courts, legislatures and the rule of law itself. In these situations of hyperpolarization, citizens on one side of the political divide relinquish their own rights as long as this gives their side the upper hand over the
October 22, 2025 at 12:49 PM
of the other feel so great that some citizens acquiesce to the weakening of courts, legislatures and the rule of law itself. In these situations of hyperpolarization, citizens on one side of the political divide relinquish their own rights as long as this gives their side the upper hand over the
Register for the Hyperpolarization Study Group Virtual Meeting:
Beyond Pyruvate: Development & Clinical Translation of Novel Probes for Hyperpolarized MRI
27 October 2025 | 16:00 UTC
Registration is FREE for members! Learn more & register: https://ow.ly/cLMG50X8Sxf
#ISMRM #ISMRT #MRI #MR
Beyond Pyruvate: Development & Clinical Translation of Novel Probes for Hyperpolarized MRI
27 October 2025 | 16:00 UTC
Registration is FREE for members! Learn more & register: https://ow.ly/cLMG50X8Sxf
#ISMRM #ISMRT #MRI #MR
October 13, 2025 at 5:00 PM
What I come back to is our dysfunction is actually downstream of how evenly divided the electorate is by hyperpolarization. Democratic systems don't function well when there isn't a clear majority, though some systems have a better failure mode than Madisonian legitimacy crises.
September 27, 2025 at 12:18 AM
What I come back to is our dysfunction is actually downstream of how evenly divided the electorate is by hyperpolarization. Democratic systems don't function well when there isn't a clear majority, though some systems have a better failure mode than Madisonian legitimacy crises.
The hyperpolarization of everything into hypersimplistic “left” and “right” constructs means that the prevailing mindsets will struggle to get their heads around online nihilism and the gamification of accelerationism.
September 25, 2025 at 2:46 PM
The hyperpolarization of everything into hypersimplistic “left” and “right” constructs means that the prevailing mindsets will struggle to get their heads around online nihilism and the gamification of accelerationism.
So, it’s the toxic hyperpolarization, and not things like sending unconvicted immigrants AND citizens to CECOT? Or politicizing the FCC? Or sending the military to kill non combatants in foreign water, without identifying them?
Hmm, sounds to me like it’s a media problem, not a political one.
Hmm, sounds to me like it’s a media problem, not a political one.
September 21, 2025 at 10:22 PM
So, it’s the toxic hyperpolarization, and not things like sending unconvicted immigrants AND citizens to CECOT? Or politicizing the FCC? Or sending the military to kill non combatants in foreign water, without identifying them?
Hmm, sounds to me like it’s a media problem, not a political one.
Hmm, sounds to me like it’s a media problem, not a political one.
Look, I'm not going to pretend there aren't a ton of trans people with radical or revolutionary politics.
Amid rising political violence, hyperpolarization, federal power grabs, and a nationwide anti-trans crackdown, it would frankly be surprising if that /never/ resulted in violent attacks.
Amid rising political violence, hyperpolarization, federal power grabs, and a nationwide anti-trans crackdown, it would frankly be surprising if that /never/ resulted in violent attacks.
September 19, 2025 at 8:57 PM
Look, I'm not going to pretend there aren't a ton of trans people with radical or revolutionary politics.
Amid rising political violence, hyperpolarization, federal power grabs, and a nationwide anti-trans crackdown, it would frankly be surprising if that /never/ resulted in violent attacks.
Amid rising political violence, hyperpolarization, federal power grabs, and a nationwide anti-trans crackdown, it would frankly be surprising if that /never/ resulted in violent attacks.
Apart from social media and hyperpolarization and all the rest of the crud in which we are struggling to swim, we MUST get away from the obsession with demonizing trans people.
www.nytimes.com/2025/09/19/o...
www.nytimes.com/2025/09/19/o...
Opinion | We’re Seeing Two Truths of Trumpism Laid Bare
www.nytimes.com
September 19, 2025 at 10:49 AM
Apart from social media and hyperpolarization and all the rest of the crud in which we are struggling to swim, we MUST get away from the obsession with demonizing trans people.
www.nytimes.com/2025/09/19/o...
www.nytimes.com/2025/09/19/o...
This is the fundamental thing about hyperpolarization: there is no room to govern from the middle. You get something that can hold together your side of the bimodal distribution because there’s an enormous valley between you and the other peak.
September 16, 2025 at 4:34 PM
This is the fundamental thing about hyperpolarization: there is no room to govern from the middle. You get something that can hold together your side of the bimodal distribution because there’s an enormous valley between you and the other peak.
Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization
Science Advances
www.science.org/doi/10.1126/...
Science Advances
www.science.org/doi/10.1126/...
Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization
Biocompatible additives reduce nuclear relaxation and enable record-high hyperpolarization of MRI contrast agents.
www.science.org
September 16, 2025 at 1:32 AM
Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization
Science Advances
www.science.org/doi/10.1126/...
Science Advances
www.science.org/doi/10.1126/...
I think millenials were caught in the post 9/11 fever break of the 90’s, and a lot of our teachers and older siblings taught us to critically assess sources bc of the internet coming into play
Natural skepticism arose after “freedom fries” and the hyperpolarization/militarization of media as well
Natural skepticism arose after “freedom fries” and the hyperpolarization/militarization of media as well
IMO Gen X has difficulty processing it all b/c we were raised by boomers & taught garbage like "the mitochondria is the powerhouse of the cell!" But nothing about being engaged w/ politics.
Also doesn't help having the likes of Josh Hawley in Congress saying 1 thing & voting the exact opposite.
Also doesn't help having the likes of Josh Hawley in Congress saying 1 thing & voting the exact opposite.
September 15, 2025 at 1:20 PM
I think millenials were caught in the post 9/11 fever break of the 90’s, and a lot of our teachers and older siblings taught us to critically assess sources bc of the internet coming into play
Natural skepticism arose after “freedom fries” and the hyperpolarization/militarization of media as well
Natural skepticism arose after “freedom fries” and the hyperpolarization/militarization of media as well
Buddleja globosa Leaf Methanolic Extract Acts Against Trypanosoma cruzi Parasites by Inducing Mitochondrial Inner Membrane Hyperpolarization pubmed.ncbi.nlm.nih.gov/40941913/
September 14, 2025 at 11:05 PM
Buddleja globosa Leaf Methanolic Extract Acts Against Trypanosoma cruzi Parasites by Inducing Mitochondrial Inner Membrane Hyperpolarization pubmed.ncbi.nlm.nih.gov/40941913/
Buddleja globosa Leaf Methanolic Extract Acts Against Trypanosoma cruzi Parasites by Inducing Mitochondrial Inner Membrane Hyperpolarization pubmed.ncbi.nlm.nih.gov/40941913/
September 14, 2025 at 8:42 AM
Buddleja globosa Leaf Methanolic Extract Acts Against Trypanosoma cruzi Parasites by Inducing Mitochondrial Inner Membrane Hyperpolarization pubmed.ncbi.nlm.nih.gov/40941913/
Anybody who didn't expect this from US hyperpolarization was selling something and they were high on their own supply.
Europe and China and Mexico and Canada and Brazil and India literally cannot afford to just leave us to our own devices.
Acceleration is something some people take seriously.
Europe and China and Mexico and Canada and Brazil and India literally cannot afford to just leave us to our own devices.
Acceleration is something some people take seriously.
Looked at my data collections for state-backed activity. If the report were a picture:
September 14, 2025 at 4:26 AM
Anybody who didn't expect this from US hyperpolarization was selling something and they were high on their own supply.
Europe and China and Mexico and Canada and Brazil and India literally cannot afford to just leave us to our own devices.
Acceleration is something some people take seriously.
Europe and China and Mexico and Canada and Brazil and India literally cannot afford to just leave us to our own devices.
Acceleration is something some people take seriously.