This study reports that #mRNAvaccines encoding full or partial #ChikungunyaVirus structural proteins, mCV-1 & mCV-2, induced strong cellular & #HumoralImmunity and provided broad cross-lineage protection in mice & #RhesusMacaques. #medsky

#STTT #OpenAccess: doi.org/10.1038/s413...

While it was previously thought that γδ T cells primarily trigger inflammatory responses & directly kill infected cells, their contribution to #humoralimmunity during natural infection & vaccination has been a neglected area of research.

Dietary supplementation of #ArachidonicAcid promotes #HumoralImmunity

By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University

➡️ doi.org/10.1038/s443...

This commentary highlights major gaps in understanding #HumoralImmunity to #OrientiaTsutsugamushi, the cause of #Scrubtyphus, emphasizing the need for mechanistic studies of #Bcell responses to define deficiencies in acute & long-term immunity.
#OpenAccess: zoonoses-journal.org/index.php/20...

Importantly, the findings have implications for multidose vaccination schedules, highlighting ipsilateral immunization as an optimal strategy to rapidly maximize #humoralimmunity on a population level during the early phases of an infectious disease outbreak.

Subsequently, obesity-associated inflammatory insults are predicted to disturb cellular and #humoralimmunity by triggering abnormal cell differentiation and lymphocyte exhaustion….

t.co/tbprYyNLGG

#MdSky🧪#ImmunoSky Overview #autophagy roles on #Bcell development, maturation & Their capacity to generate long lasting #humoralimmunity against microbial pathogens enables #Bcells to protect the host against repeated infections, provides for vaccine efficacy
www.frontiersin.org/journals/imm...

MedSky 🧪 IDSky #Viralimmunology #Immunology #CovidIsNotOver @systemsvirology #Maskup😷 #Getboosted EG.5.1 has a characteristic amino acid substitution in the spike protein (S), S:F456L, which contributes to its escape from #humoralimmunity.

After antigens from infection or vaccine antigens have been cleared, long-lived plasma cells and memory B cells persist to maintain #humoralimmunity.

MedSky🧪Analysis of the association between the new #SARSCoV2 variant EG.5 & XBB breakthrough infection, BTI of XBB subvariants cannot efficiently induce antiviral #humoralimmunity against the infecting variants vs the BTI of previous #omicron variants.