Excited to announce our new ARPA-H award to “Close the DOORs” mapping how viruses exploit human cells and learning how to shut them. Grateful to @arpa-h.bsky.social and our amazing team!
🔗 www.mountsinai.org/about/newsro...
#ARPAH #Virology #HostPathogen #Innovation #Science
🔗 www.mountsinai.org/about/newsro...
#ARPAH #Virology #HostPathogen #Innovation #Science
Mount Sinai Awarded Up to $11.8 Million From ARPA-H to Close the Doors in Human Cells That Viruses Exploit to Infect, Replicate, and Spread
www.mountsinai.org
October 21, 2025 at 2:23 PM
Excited to announce our new ARPA-H award to “Close the DOORs” mapping how viruses exploit human cells and learning how to shut them. Grateful to @arpa-h.bsky.social and our amazing team!
🔗 www.mountsinai.org/about/newsro...
#ARPAH #Virology #HostPathogen #Innovation #Science
🔗 www.mountsinai.org/about/newsro...
#ARPAH #Virology #HostPathogen #Innovation #Science
Using in vivo single-cell transcriptomics, we show how bacterial cells, just millimetres apart, use 6S RNA to coordinate virulence and stress adaptation during epithelial barrier crossing
#microbiology #6SRNA #spatialomics #hostpathogen #preprint
#microbiology #6SRNA #spatialomics #hostpathogen #preprint
6S RNA facilitates bacterial virulence and adaptation at the epithelial barrier https://www.biorxiv.org/content/10.1101/2025.10.07.681022v1
October 9, 2025 at 8:55 PM
Using in vivo single-cell transcriptomics, we show how bacterial cells, just millimetres apart, use 6S RNA to coordinate virulence and stress adaptation during epithelial barrier crossing
#microbiology #6SRNA #spatialomics #hostpathogen #preprint
#microbiology #6SRNA #spatialomics #hostpathogen #preprint
🔥 Pathogenic bacteria don’t guess — they play to win.
Their business is killing… and business is good.
👉 hal.science/hal-05230483
#Microbiology #HostPathogen #GameTheory
When Theory Meets Genomics: Reconciling Game Dynamics and Within-Host Evolution
Their business is killing… and business is good.
👉 hal.science/hal-05230483
#Microbiology #HostPathogen #GameTheory
When Theory Meets Genomics: Reconciling Game Dynamics and Within-Host Evolution
When Theory Meets Genomics: Reconciling Game Dynamics and Within-Host Evolution
Virulence is a context-dependent strategy, not a fixed trait. Building on Tonkin-Hill et al., a game-theoretical framework predicts when pathogens invest in immune evasion or shift to rapid replicatio...
hal.science
September 19, 2025 at 8:15 PM
🔥 Pathogenic bacteria don’t guess — they play to win.
Their business is killing… and business is good.
👉 hal.science/hal-05230483
#Microbiology #HostPathogen #GameTheory
When Theory Meets Genomics: Reconciling Game Dynamics and Within-Host Evolution
Their business is killing… and business is good.
👉 hal.science/hal-05230483
#Microbiology #HostPathogen #GameTheory
When Theory Meets Genomics: Reconciling Game Dynamics and Within-Host Evolution
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
September 8, 2025 at 10:15 AM
🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome.
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🎉Congrats Virginie Girault et al!
🔍 Explore: www.ebi.ac.uk/intact/searc...
#IntAct #HostPathogen #@a_pichlmair
🛋️ Thinking of what to read this weekend? Why not revisit this review on influenza antivirals and animal models? 🐁
🔓https://buff.ly/38pgO0f
👩🔬 @juaco1802.bsky.social
#Influenza #HostPathogen
🔓https://buff.ly/38pgO0f
👩🔬 @juaco1802.bsky.social
#Influenza #HostPathogen
September 5, 2025 at 2:28 PM
🛋️ Thinking of what to read this weekend? Why not revisit this review on influenza antivirals and animal models? 🐁
🔓https://buff.ly/38pgO0f
👩🔬 @juaco1802.bsky.social
#Influenza #HostPathogen
🔓https://buff.ly/38pgO0f
👩🔬 @juaco1802.bsky.social
#Influenza #HostPathogen
Wang (Columbia) & Parker (Rutgers): New humanized mouse with autologous lung implants captures S. aureus infection dynamics: loss of human immune cells & cytokine surge. Bacterial stress-response essential for persistence go.njmicrobe.org/4NgYMT #Staph #Aureus #HostPathogen #MedicalMicrobiology
Staphylococcus aureus Research: Humanized Lung Models Unveil Host-Pathogen Dynamics
Staphylococcus aureus remains a formidable human pathogen, being a leading cause of bacterial-induced death, with significant concerns regarding antibiotic resistance and the current lack of an effective vaccine. A major hurdle in combating S. aureus is that it is a human-adapted pathogen, expressing virulence factors specific to human cellular receptors. This specificity limits the utility of traditional mouse models, which often fail to accurately replicate human-specific host responses to inf
go.njmicrobe.org
August 25, 2025 at 11:31 AM
Wang (Columbia) & Parker (Rutgers): New humanized mouse with autologous lung implants captures S. aureus infection dynamics: loss of human immune cells & cytokine surge. Bacterial stress-response essential for persistence go.njmicrobe.org/4NgYMT #Staph #Aureus #HostPathogen #MedicalMicrobiology
Published in PLOS Pathogens with Marius Zeeb and Alexandra Trkola. These results deepen our understanding of HIV/MTB co-infection and open paths for novel immunological diagnostics.
#Immunology #HIV #Tuberculosis #HostPathogen #USZ #AdaptiveImmunity #SwissHIVCohort
#Immunology #HIV #Tuberculosis #HostPathogen #USZ #AdaptiveImmunity #SwissHIVCohort
August 15, 2025 at 11:54 AM
Published in PLOS Pathogens with Marius Zeeb and Alexandra Trkola. These results deepen our understanding of HIV/MTB co-infection and open paths for novel immunological diagnostics.
#Immunology #HIV #Tuberculosis #HostPathogen #USZ #AdaptiveImmunity #SwissHIVCohort
#Immunology #HIV #Tuberculosis #HostPathogen #USZ #AdaptiveImmunity #SwissHIVCohort
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Our new article in Current Protocols is out: Microbiologists, immunologists, host-pathogen folks: this one’s for you 🧬🦠 #Klebsiella #HostPathogen #Microbiology
Huge thanks to my mentor @azmicro.bsky.social for the guidance and support!
Our new article in Current Protocols is out: Microbiologists, immunologists, host-pathogen folks: this one’s for you 🧬🦠 #Klebsiella #HostPathogen #Microbiology
Huge thanks to my mentor @azmicro.bsky.social for the guidance and support!
Murine Models of Klebsiella pneumoniae Gastrointestinal Infection
Klebsiella pneumoniae (Kpn) is a Gram-negative opportunistic pathogen and a leading cause of hospital-acquired infections. The gastrointestinal (GI) tract serves as a critical site for Kpn colonizati....
currentprotocols.onlinelibrary.wiley.com
August 5, 2025 at 9:06 PM
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...
Our new article in Current Protocols is out: Microbiologists, immunologists, host-pathogen folks: this one’s for you 🧬🦠 #Klebsiella #HostPathogen #Microbiology
Huge thanks to my mentor @azmicro.bsky.social for the guidance and support!
Our new article in Current Protocols is out: Microbiologists, immunologists, host-pathogen folks: this one’s for you 🧬🦠 #Klebsiella #HostPathogen #Microbiology
Huge thanks to my mentor @azmicro.bsky.social for the guidance and support!
Just out in Infection and Immunity!
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen
Live fast, die young: neutrophils streamline their metabolism to maximize inflammation | Infection and Immunity
Cell metabolism plays a key role in shaping immune cell differentiation and function,
with each immune cell subset depending on distinct metabolic pathways. While there
have been extensive studies and...
journals.asm.org
July 7, 2025 at 7:25 PM
Just out in Infection and Immunity!
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen
Our latest review explores how neutrophils balance antimicrobial defense with tissue protection during infection, with a focus on metabolic signaling and NETs.
Read it here: journals.asm.org/doi/full/10....
#neutrophils #immunometabolism #NETosis #hostpathogen
#HostPathogen models for the study of #UTI #Infections🔬. Incredible work from Abell-King et al. exploring #multispecies #bacterial behaviour using clinical strains and human bladder models 🧫. Read it here: buff.ly/4aGNxKD #PathogDis #KPneumoniae #Efaecalis #UPEC
June 25, 2025 at 8:02 AM
#HostPathogen models for the study of #UTI #Infections🔬. Incredible work from Abell-King et al. exploring #multispecies #bacterial behaviour using clinical strains and human bladder models 🧫. Read it here: buff.ly/4aGNxKD #PathogDis #KPneumoniae #Efaecalis #UPEC
Can M. tuberculosis stop macrophages from moving? Ahri Han shows how its effector PPE15 may bind N-WASP to disrupt actin-driven migration—potentially helping the pathogen evade immune system. Read more: wix.to/9KbMnIg #HealthResearch #Microbiology #Actin #HostPathogen #Tuberculosis #Mycobacterium
How Mycobacterium tuberculosis Disarms Macrophages: Ahri Han Investigates Actin and Migration
At the 2025 Theobald Smith Society Spring Symposium, MD/PhD student Ahri Han from Samantha Bell’s Lab at Rutgers New Jersey Medical School presented compelling early-stage work investigating how Mycob...
wix.to
May 15, 2025 at 9:11 PM
Can M. tuberculosis stop macrophages from moving? Ahri Han shows how its effector PPE15 may bind N-WASP to disrupt actin-driven migration—potentially helping the pathogen evade immune system. Read more: wix.to/9KbMnIg #HealthResearch #Microbiology #Actin #HostPathogen #Tuberculosis #Mycobacterium
On #WorldTBday @leidenscience.bsky.social "Dutch Perspective on Mycobacterial Infections" provided insights on #hostpathogen interactions #drugdevelopment & #immunology from global leaders. Unfortunatley, #MDR #infections continue to rise, urgently requiring new #drugs with new #targets
Symposium: A Dutch Perspective on Mycobacterial Infections
On the 24th of March 2025, World TB day, we organize a symposium to connect the Dutch scientific community working on mycobacterial infections. We will cover all aspects of tuberculous or non-tubercul...
www.universiteitleiden.nl
March 24, 2025 at 4:06 PM
On #WorldTBday @leidenscience.bsky.social "Dutch Perspective on Mycobacterial Infections" provided insights on #hostpathogen interactions #drugdevelopment & #immunology from global leaders. Unfortunatley, #MDR #infections continue to rise, urgently requiring new #drugs with new #targets
An animal house murder mystery fm Marcelo Bozza et al
"While breeding for double-deficient Mif-/-Il10-/- mice, we unexpectedly observed that Il10-/- individuals died within days after co-housing with Mif-/- mice."
#Preprint #Immunology #HostPathogen
www.biorxiv.org/content/10.1...
"While breeding for double-deficient Mif-/-Il10-/- mice, we unexpectedly observed that Il10-/- individuals died within days after co-housing with Mif-/- mice."
#Preprint #Immunology #HostPathogen
www.biorxiv.org/content/10.1...
Disease tolerant mice shelter a pathogenic intestinal microbiota able to trigger lethal disease in low tolerant hosts
Disease tolerance is a defensive strategy that limits tissue damage during infection. Macrophage migration inhibitory factor (MIF)-deficient mice ( Mif-/- ) are protected in different models of infect...
www.biorxiv.org
March 4, 2025 at 4:34 PM
An animal house murder mystery fm Marcelo Bozza et al
"While breeding for double-deficient Mif-/-Il10-/- mice, we unexpectedly observed that Il10-/- individuals died within days after co-housing with Mif-/- mice."
#Preprint #Immunology #HostPathogen
www.biorxiv.org/content/10.1...
"While breeding for double-deficient Mif-/-Il10-/- mice, we unexpectedly observed that Il10-/- individuals died within days after co-housing with Mif-/- mice."
#Preprint #Immunology #HostPathogen
www.biorxiv.org/content/10.1...
Thanks so
much for the invitation @irbbarcelona.org ! I hope this will raise the interest in #drosophila as a #experimentalmodel for #tuberculosis #hostpathogen #coevolution #sexualdimorphism #mdr #antibiotics #chemotherapy #toxicology and #regulatory @igtp.bsky.social
much for the invitation @irbbarcelona.org ! I hope this will raise the interest in #drosophila as a #experimentalmodel for #tuberculosis #hostpathogen #coevolution #sexualdimorphism #mdr #antibiotics #chemotherapy #toxicology and #regulatory @igtp.bsky.social
🧪Don't miss our plenary #seminar this week, by @pjcardona14.bsky.social, from @igtp.bsky.social.
Register here ➡️ https://shorturl.at/kKn27
#BarcelonaBiomed #Drosophila #DrosophilaResearch
Register here ➡️ https://shorturl.at/kKn27
#BarcelonaBiomed #Drosophila #DrosophilaResearch
February 24, 2025 at 10:09 AM
Thanks so
much for the invitation @irbbarcelona.org ! I hope this will raise the interest in #drosophila as a #experimentalmodel for #tuberculosis #hostpathogen #coevolution #sexualdimorphism #mdr #antibiotics #chemotherapy #toxicology and #regulatory @igtp.bsky.social
much for the invitation @irbbarcelona.org ! I hope this will raise the interest in #drosophila as a #experimentalmodel for #tuberculosis #hostpathogen #coevolution #sexualdimorphism #mdr #antibiotics #chemotherapy #toxicology and #regulatory @igtp.bsky.social
@cabd-upo-csic.bsky.social thanks so much for the invitation Tanja Dapta and for the inspiring talks on #microbiota #hostpathogen interactions and #mdr bacteria ! A seed for future collaborations! @igtp.bsky.social @scmimc.bsky.social #hugtip #uautonomabarcelona
Amazing talk today at #CABDseminars with @pjcardona14.bsky.social explaining the studies on #tuberculosis using #fruitfly! Pere-Joan was invited by Tanja Dapa.
Thanks for coming!
Thanks for coming!
February 21, 2025 at 5:12 PM
@cabd-upo-csic.bsky.social thanks so much for the invitation Tanja Dapta and for the inspiring talks on #microbiota #hostpathogen interactions and #mdr bacteria ! A seed for future collaborations! @igtp.bsky.social @scmimc.bsky.social #hugtip #uautonomabarcelona
We are thrilled to announce the world's first targeted Vector-Pathogen primer for RNA-seq! This initial application is for selective exome gene expression analysis of a Tick-Borrelia-Fungi system.
Working with Host/Vector-Pathogen systems?
We are excited to help 🧪🧬
multitarga.com/hostpathogen
Working with Host/Vector-Pathogen systems?
We are excited to help 🧪🧬
multitarga.com/hostpathogen
February 4, 2025 at 6:01 PM
We are thrilled to announce the world's first targeted Vector-Pathogen primer for RNA-seq! This initial application is for selective exome gene expression analysis of a Tick-Borrelia-Fungi system.
Working with Host/Vector-Pathogen systems?
We are excited to help 🧪🧬
multitarga.com/hostpathogen
Working with Host/Vector-Pathogen systems?
We are excited to help 🧪🧬
multitarga.com/hostpathogen
The importance of #HostPathogen models for the study of #UTI infections🔬. Check out our Latest Editor's Choice: Abell-King et al. explore #multispecies #bacterial behaviour using clinical strains and human #bladder models 🧫.
https://buff.ly/4aGNxKD
#PathogDis
https://buff.ly/4aGNxKD
#PathogDis
February 3, 2025 at 9:00 AM
The importance of #HostPathogen models for the study of #UTI infections🔬. Check out our Latest Editor's Choice: Abell-King et al. explore #multispecies #bacterial behaviour using clinical strains and human #bladder models 🧫.
https://buff.ly/4aGNxKD
#PathogDis
https://buff.ly/4aGNxKD
#PathogDis
"What makes a super-spreader? Unravelling the genetics of host infectiousness"
Funded #PhD position in my lab exploring the drivers of host heterogeneity in pathogen transmission. Get in touch if interested. Deadline 17 Jan 2025.
#HostPathogen #DiseaseEcology
www.findaphd.com/phds/project...
Funded #PhD position in my lab exploring the drivers of host heterogeneity in pathogen transmission. Get in touch if interested. Deadline 17 Jan 2025.
#HostPathogen #DiseaseEcology
www.findaphd.com/phds/project...
EastBio: What makes a super-spreader? Unravelling the genetics of host infectiousness. at University of Edinburgh on FindAPhD.com
PhD Project - EastBio: What makes a super-spreader? Unravelling the genetics of host infectiousness. at University of Edinburgh, listed on FindAPhD.com
www.findaphd.com
December 11, 2024 at 8:01 PM
"What makes a super-spreader? Unravelling the genetics of host infectiousness"
Funded #PhD position in my lab exploring the drivers of host heterogeneity in pathogen transmission. Get in touch if interested. Deadline 17 Jan 2025.
#HostPathogen #DiseaseEcology
www.findaphd.com/phds/project...
Funded #PhD position in my lab exploring the drivers of host heterogeneity in pathogen transmission. Get in touch if interested. Deadline 17 Jan 2025.
#HostPathogen #DiseaseEcology
www.findaphd.com/phds/project...
Found some old microscopy data. I love lymphoid and non lymphoid organ structure #fluorescenceFriday #microscopy #hostpathogen #spleen
November 29, 2024 at 6:39 PM
Found some old microscopy data. I love lymphoid and non lymphoid organ structure #fluorescenceFriday #microscopy #hostpathogen #spleen
Tagging #SybioSky #IDSky #Drosophila #HostPathogen #DiseaseEcology #Evolution #MicroSky #EcoECRcareer
@uoe-eid.bsky.social
@uoe-eid.bsky.social
November 28, 2024 at 2:02 PM
I study tissue resident macrophages and neuroimmune interaction in health and disease. I predominately utilize confocal imaging and transgenic mouse models to understand these interactions. Reach out if you want to collaborate. #immunology #science #confocal #hostpathogen #neuroimmune #neurobiology
November 27, 2024 at 8:43 PM
I study tissue resident macrophages and neuroimmune interaction in health and disease. I predominately utilize confocal imaging and transgenic mouse models to understand these interactions. Reach out if you want to collaborate. #immunology #science #confocal #hostpathogen #neuroimmune #neurobiology
#immunology -st like me , think the immune system is complicated, until they start studying #hostpathogen interactions 😱
November 25, 2024 at 4:06 PM
#immunology -st like me , think the immune system is complicated, until they start studying #hostpathogen interactions 😱
The labs of Prof Darryl Desveaux and Prof David Guttman use a systems-level approach to study the arms race between pathogen and host that takes into account the natural diversity of individual species 🧪🦠 #SystemsBiology #HostPathogen #PlantScience
csb.utoronto.ca/benign-bacte...
csb.utoronto.ca/benign-bacte...
Benign bacteria can cooperatively cause virulence - Department of Cell & Systems Biology
Nature Microbiology study finds distinct bacteria living in a community are collectively able to provoke disease without any single bacterium being the cause
csb.utoronto.ca
November 21, 2024 at 10:25 PM
The labs of Prof Darryl Desveaux and Prof David Guttman use a systems-level approach to study the arms race between pathogen and host that takes into account the natural diversity of individual species 🧪🦠 #SystemsBiology #HostPathogen #PlantScience
csb.utoronto.ca/benign-bacte...
csb.utoronto.ca/benign-bacte...
SARS-CoV-2 hijacks cholesterol trafficking to fuel infection and evade immune responses 🧬🦠🔬 www.news-medical.net/news/2024111... #COVID19 #SARSCoV2 #Cholesterol #LipidMetabolism #ORF3a #ViralMechanism #HostPathogen #Metabolic @biorxivpreprint.bsky.social
SARS-CoV-2 hijacks cholesterol trafficking to fuel infection and evade immune responses
SARS-CoV-2 disrupts cholesterol metabolism by using its ORF3a protein to sequester cholesterol in lysosomes, reducing BMP levels and optimizing viral survival. This novel mechanism offers insights int...
www.news-medical.net
November 20, 2024 at 4:28 AM
SARS-CoV-2 hijacks cholesterol trafficking to fuel infection and evade immune responses 🧬🦠🔬 www.news-medical.net/news/2024111... #COVID19 #SARSCoV2 #Cholesterol #LipidMetabolism #ORF3a #ViralMechanism #HostPathogen #Metabolic @biorxivpreprint.bsky.social