I think this debate is our Cajal vs Golgi moment but it shouldn’t be. Neural code is most probably both distributed and localized. My issue is why do we treat our decoding results as if they’re causally relevant so we end up inflating the evidence for distributed coding? Marcus has a nice example:
These, and other, studies show that you can decode task-related signals from many brain areas.
But wouldn't we need causal manipulations to conclude that the brain "uses" them?
For example, maybe we can decode equally well from two areas. But, only one impacts behaviour when inactivated.
But wouldn't we need causal manipulations to conclude that the brain "uses" them?
For example, maybe we can decode equally well from two areas. But, only one impacts behaviour when inactivated.
September 4, 2025 at 9:11 PM
I think this debate is our Cajal vs Golgi moment but it shouldn’t be. Neural code is most probably both distributed and localized. My issue is why do we treat our decoding results as if they’re causally relevant so we end up inflating the evidence for distributed coding? Marcus has a nice example:
In @jcb.org, Dennison and Baldridge @umich.edu reveal how the #Golgi-localized Tul1 #ubiquitin ligase complex targets substrates to the #proteasome versus the vacuole in S. cerevisiae. rupress.org/jcb/article/...
#Biochemistry #ProteinHomeostasis
#Biochemistry #ProteinHomeostasis
July 22, 2025 at 4:30 PM
In @jcb.org, Dennison and Baldridge @umich.edu reveal how the #Golgi-localized Tul1 #ubiquitin ligase complex targets substrates to the #proteasome versus the vacuole in S. cerevisiae. rupress.org/jcb/article/...
#Biochemistry #ProteinHomeostasis
#Biochemistry #ProteinHomeostasis
Dennison and Baldridge @umich.edu reveal how the #Golgi-localized Tul1 #ubiquitin ligase complex targets substrates to the #proteasome versus the vacuole in S. cerevisiae. rupress.org/jcb/article/...
#Biochemistry #ProteinHomeostasis
#Biochemistry #ProteinHomeostasis
July 22, 2025 at 4:15 PM
Dennison and Baldridge @umich.edu reveal how the #Golgi-localized Tul1 #ubiquitin ligase complex targets substrates to the #proteasome versus the vacuole in S. cerevisiae. rupress.org/jcb/article/...
#Biochemistry #ProteinHomeostasis
#Biochemistry #ProteinHomeostasis
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease | Science Signaling www.science.org/doi/10.1126/...
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease
An Alzheimer’s disease–associated mutation in the kinase PKCη concentrates its activity at the Golgi.
www.science.org
July 2, 2025 at 3:42 PM
A PKCη missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer’s disease | Science Signaling www.science.org/doi/10.1126/...
Strikingly, we noticed more syncytia formation without E. Although WT SARS2 can transmit cell-to-cell, deltaE virus can only spread that way. This is because without E, more Spike is localized to the cell membrane rather than staying in the Golgi/ERGIC where the virus is formed. 3/
May 23, 2025 at 11:44 AM
Strikingly, we noticed more syncytia formation without E. Although WT SARS2 can transmit cell-to-cell, deltaE virus can only spread that way. This is because without E, more Spike is localized to the cell membrane rather than staying in the Golgi/ERGIC where the virus is formed. 3/
Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder marked by bilateral calcium deposition in the brain parenchyma. Siggervåg et al. review the role of the Golgi-localized protein NAA60 in PFBC. tinyurl.com/2tnyp37z
May 21, 2025 at 10:41 AM
Primary familial brain calcification (PFBC) is a genetically heterogeneous disorder marked by bilateral calcium deposition in the brain parenchyma. Siggervåg et al. review the role of the Golgi-localized protein NAA60 in PFBC. tinyurl.com/2tnyp37z
Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.05.13.25327562v1
http://medrxiv.org/cgi/content/short/2025.05.13.25327562v1
May 15, 2025 at 7:01 AM
Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.05.13.25327562v1
http://medrxiv.org/cgi/content/short/2025.05.13.25327562v1
Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance https://www.medrxiv.org/content/10.1101/2025.05.13.25327562v1
May 15, 2025 at 4:26 AM
Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance https://www.medrxiv.org/content/10.1101/2025.05.13.25327562v1
Just Published: Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa …
doi.org/10.1111/tra....
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa …
doi.org/10.1111/tra....
Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
The model illustrates the function of Arl15 in vesicular transport and cell surface organization. Arl15 localizes majorly to the Golgi and plasma membrane (PM), which is primarily dependent on Arf1-d...
doi.org
May 2, 2025 at 2:23 PM
Just Published: Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa …
doi.org/10.1111/tra....
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa …
doi.org/10.1111/tra....
Just Published: Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa … See all authors
doi.org/10.1111/tra....
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa … See all authors
doi.org/10.1111/tra....
May 2, 2025 at 2:19 PM
Just Published: Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa … See all authors
doi.org/10.1111/tra....
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa … See all authors
doi.org/10.1111/tra....
Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion - Sharma - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
The model illustrates the function of Arl15 in vesicular transport and cell surface organization. Arl15 localizes majorly to the Golgi and plasma membrane (PM), which is primarily dependent on Arf1-d...
onlinelibrary.wiley.com
April 21, 2025 at 2:47 PM
Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion - Sharma - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
hm, no. I've seen in videos by dylan burnette that mitos are dragged around the nucleus, or the golgi. in any case, rarely localized close to or at the cytoplasmic membrane.
schaechter.asmblog.org/schaechter/2...
schaechter.asmblog.org/schaechter/2...
March 19, 2025 at 12:28 AM
hm, no. I've seen in videos by dylan burnette that mitos are dragged around the nucleus, or the golgi. in any case, rarely localized close to or at the cytoplasmic membrane.
schaechter.asmblog.org/schaechter/2...
schaechter.asmblog.org/schaechter/2...
We did an extensive virus screen and found that OAS2 restricts viruses that replicate using endomembrane system forming double membrane vesicles. Only OAS2 WT that is dimeric and localized to golgi is able to restrict viruses showing that oligomeric state and location are key!
January 29, 2025 at 7:14 AM
We did an extensive virus screen and found that OAS2 restricts viruses that replicate using endomembrane system forming double membrane vesicles. Only OAS2 WT that is dimeric and localized to golgi is able to restrict viruses showing that oligomeric state and location are key!
#EarlyView👁🗨A Golgi vesicle-membrane-localized cytochrome B561 regulates ascorbic acid regeneration and confers Verticillium wilt resistance in cotton👉http://doi.org/10.1111/tpj.17162 Golgi-GhB561-11+lipid droplet GhLDAP3 regulate AsA regeneration, H2O2 homeostasis & ⬆️resistance to Verticillum wilt
November 28, 2024 at 10:20 AM
#EarlyView👁🗨A Golgi vesicle-membrane-localized cytochrome B561 regulates ascorbic acid regeneration and confers Verticillium wilt resistance in cotton👉http://doi.org/10.1111/tpj.17162 Golgi-GhB561-11+lipid droplet GhLDAP3 regulate AsA regeneration, H2O2 homeostasis & ⬆️resistance to Verticillum wilt
By "membrane localized" I thought they were referring to the cell membrane, and was feeling like a fool for not knowing about it.
Now I see it means the golgi, and feel even more foolish.
I guess you just have to live, learn, and then remember what happens to ribosomes after they're assembled.
Now I see it means the golgi, and feel even more foolish.
I guess you just have to live, learn, and then remember what happens to ribosomes after they're assembled.
How long does an mRNA stay in the nucleus? How long does it stay in the cytoplasm? In an amazing collaboration with @landthalerm.bsky.social, we used metabolic labeling, cell fractionation and mathematical modeling to quantify mRNA flow through the cell. Finally out in MSB: doi.org/10.1038/s443...
November 24, 2024 at 3:07 PM
By "membrane localized" I thought they were referring to the cell membrane, and was feeling like a fool for not knowing about it.
Now I see it means the golgi, and feel even more foolish.
I guess you just have to live, learn, and then remember what happens to ribosomes after they're assembled.
Now I see it means the golgi, and feel even more foolish.
I guess you just have to live, learn, and then remember what happens to ribosomes after they're assembled.
Preprint from ASAP Team De Camilli: VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1. Here, the team studies the role of VPS13b protein in lipid transport. 🧪📈 🧠
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
January 29, 2024 at 5:53 PM
Preprint from ASAP Team De Camilli: VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1. Here, the team studies the role of VPS13b protein in lipid transport. 🧪📈 🧠
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1 https://www.biorxiv.org/content/10.1101/2023.12.18.572081v1
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1 https://www.biorxiv.org/content/10.1101/2023.12.18.572081v1
Mutations in VPS13B, a member of a protein family implicated in bulk lipid transport between adjacen
www.biorxiv.org
December 19, 2023 at 1:31 AM
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1 https://www.biorxiv.org/content/10.1101/2023.12.18.572081v1
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1 https://www.biorxiv.org/content/10.1101/2023.12.18.572081v1
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1 https://www.biorxiv.org/content/10.1101/2023.12.18.572081v1
Mutations in VPS13B, a member of a protein family implicated in bulk lipid transport between adjacen
www.biorxiv.org
December 19, 2023 at 1:31 AM
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1 https://www.biorxiv.org/content/10.1101/2023.12.18.572081v1
Selective activation of Golgi-localized β1AR www.biorxiv.org/content/10.1...
Selective activation of intracellular β1AR using a spatially restricted antagonist
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
November 26, 2023 at 4:05 AM
Selective activation of Golgi-localized β1AR www.biorxiv.org/content/10.1...
Our Abiotic Stresses section examines salt, phosphate, and drought, plus this interesting paper about lipid droplets. "Golgi-localized MORN1 promotes lipid droplet abundance and enhances tolerance to multiple stresses in Arabidopsis" onlinelibrary.wiley.com/doi/epdf/10....
https://onlinelibrary.wiley.com/doi/epdf/10.1111/jipb.13498
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onlinelibrary.wiley.com
August 31, 2023 at 10:28 PM
Our Abiotic Stresses section examines salt, phosphate, and drought, plus this interesting paper about lipid droplets. "Golgi-localized MORN1 promotes lipid droplet abundance and enhances tolerance to multiple stresses in Arabidopsis" onlinelibrary.wiley.com/doi/epdf/10....
Golgi-localized STELLO proteins regulate the assembly and trafficking of cellulose synthase complexes in Arabidopsis <a href="http://rdcu.be/iN5Y" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">http://rdcu.be/iN5Y
June 13, 2016 at 6:36 AM
Golgi-localized STELLO proteins regulate the assembly and trafficking of cellulose synthase complexes in Arabidopsis <a href="http://rdcu.be/iN5Y" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">http://rdcu.be/iN5Y