#GenomeEditing
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sigtrans-sttt.bsky.social
Researchers elucidate the molecular basis of Cas12h1’s #nickase function, revealing its phage-related evolution and enabling the rational engineering of Cas12h1hf, a compact, high-fidelity #CRISPR tool for precise #GenomeEditing.

#OpenAccess in #STTT: doi.org/10.1038/s413...
Molecular insights and rational engineering of a compact CRISPR-Cas effector Cas12h1 with a broad-spectrum PAM - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Molecular insights and rational engineering of a compact CRISPR-Cas effector Cas12h1 with a broad-spectrum PAM
doi.org
November 11, 2025 at 10:54 AM
jsantoyo.bsky.social
Site-specific DNA insertion into the human genome with engineered recombinases. #GenomeEditing #DNAinsertion #LargeSerineRecombinases @natbiotech.nature.com
www.nature.com/articles/s41...
November 8, 2025 at 8:05 PM
aridoge13.bsky.social
CRISPR-Cas9 lets scientists edit DNA with extreme precision.
In 2019, Harvard researchers used it to restore hearing in Beethoven mice by correcting a single mutation in the Tmc1 gene with no off-target effects.
Source: doi.org/10.1038/s415...

#Genomics #CRISPR #GenomeEditing #DoOnlyGoodEveryday
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss - Nature Medicine
Screening of Cas9 and gRNA combinations identifies the variant SaCas9-KKH that selectively disrupts the mutant Tmc1/TMC1 allele that causes hearing loss, prevents deafness and preserves inner-ear hair...
doi.org
November 4, 2025 at 3:40 PM
mbuchholzer.bsky.social
Excited to share our new Nature Biotechnology comment! Together with our amazing colleagues, we discuss why long-read whole genome sequencing should be the standard to verify transgene-free genome-edited crops.
#genomeediting #plantscience
healthycrops.bsky.social Healthy Crops @healthycrops.bsky.social · 11d
Genome editing can revolutionize agriculture, but only if we ensure it is safe and transparent.
Our comment in Nature Biotech highlights why long-read whole genome sequencing should be the standard to confirm that genome-edited plants are free of foreign DNA.
🔗 buff.ly/zrgWbn4
Ensuring effective removal of transgenes before release of genome-edited crops - Nature Biotechnology
Genome editing technology is evolving fast, and many labs worldwide are generating crop plants with improved traits. If transgenes were used to generate the edits, foreign DNA must be effectively…
doi.org
October 31, 2025 at 1:47 PM
annizlab.bsky.social
#microbiome #GenomeEditing
October 31, 2025 at 1:38 PM
healthycrops.bsky.social
PCR or short-read sequencing may miss partial insertions from transformation vectors. Such fragments could reclassify plants as GMOs, with major regulatory and reputational risks. Long-read WGS captures entire insertion regions, and eliminates false positives.
#genomeediting #plantscience
October 31, 2025 at 9:13 AM
pet-bionews.bsky.social
Large-scale use of cell and gene therapies could result in economic gain of over £20 billion over 10 years...
Flavia Matos Santo writes about this report in BioNews: www.progress.org.uk/gene-therapi...

#GeneTherapy #Gene #DNA #Health #NHS #HealthEconomics #GenomeEditing
October 30, 2025 at 6:50 PM
laurenctesta.bsky.social
This paper was truly a team effort, thanks to all who came together and made it happen! #CRISPR #GeneEditing #GenomeEditing #BaseEditing #AdenineBaseEditing
October 28, 2025 at 12:58 PM
kwsgroup.bsky.social
🧬 An interesting review highlights how #GenomeEditing tools are being used to improve stress tolerance and quality traits in vegetable crops.
🔗: https://ow.ly/awfi50XiqVB
October 27, 2025 at 6:01 PM
jsantoyo.bsky.social
Discovery and engineering of retrons for precise genome editing. #GenomeEditing @natbiotech.nature.com
www.nature.com/articles/s41...
October 27, 2025 at 12:15 PM
plosbiology.org
Bacteria rely on retrons for #phage defense, but most known systems come from clinical or lab strains. @seth-shipman.bsky.social &co identify diverse #retrons from environmental #bacteria, uncovering their defense mechanisms & using them as #GenomeEditing tools @plosbiology.org 🧪 plos.io/4oDqRAF
Isolation of retron-bearing hosts from environmental samples. Top: Schematic of the isolation of bacteria from soil and water samples and identification of possible retron-bearing hosts using PAGE analysis (from left). Retron RT-DNA bands from PAGE analyses. Overview of sampling, screening of colonies, and identification of retron hosts. Hosts displaying an RT-DNA band were subjected to whole-genome sequencing. RT-DNA was subjected to unbiased adapter addition and sequencing. Bottom: Top left panel: Schematic of canonical retron operon with components annotated, effector in pink, noncoding RNA (ncRNA) in orange, and reverse transcriptase in purple. Other seven panels: Seven putative retron operons, identifying the retron type, host species, and predicted two-dimensional structure of the ncRNA. For retrons where RT-DNA sequencing is available, sequencing coverage is plotted onto ncRNA in an orange heatmap (heatmap legend indicated number of sequencing reads mapped). Gene abbreviations: NDT (nucleoside deoxyribosyltransferase-like); PRTase (phosphoribosyltransferase); WH (winged helix-turn-helix DNA binding); HTH (helix-turn-helix domain containing); HipA (HipA-like); DUF (DUF3037 domain-containing protein).
October 27, 2025 at 8:58 AM
plosbiology.org
Bacteria rely on retrons for #phage defense, but most known systems come from clinical or lab strains. @seth-shipman.bsky.social &co identify diverse #retrons from environmental #bacteria, uncovering their defense mechanisms & using them as #GenomeEditing tools @plosbiology.org 🧪 plos.io/4oDqRAF
Isolation of retron-bearing hosts from environmental samples. Top: Schematic of the isolation of bacteria from soil and water samples and identification of possible retron-bearing hosts using PAGE analysis (from left). Retron RT-DNA bands from PAGE analyses. Overview of sampling, screening of colonies, and identification of retron hosts. Hosts displaying an RT-DNA band were subjected to whole-genome sequencing. RT-DNA was subjected to unbiased adapter addition and sequencing. Bottom: Top left panel: Schematic of canonical retron operon with components annotated, effector in pink, noncoding RNA (ncRNA) in orange, and reverse transcriptase in purple. Other seven panels: Seven putative retron operons, identifying the retron type, host species, and predicted two-dimensional structure of the ncRNA. For retrons where RT-DNA sequencing is available, sequencing coverage is plotted onto ncRNA in an orange heatmap (heatmap legend indicated number of sequencing reads mapped). Gene abbreviations: NDT (nucleoside deoxyribosyltransferase-like); PRTase (phosphoribosyltransferase); WH (winged helix-turn-helix DNA binding); HTH (helix-turn-helix domain containing); HipA (HipA-like); DUF (DUF3037 domain-containing protein).
October 24, 2025 at 4:24 PM
plosbiology.org
Bacteria rely on retrons for #phage defense, but most known systems come from clinical or lab strains. @seth-shipman.bsky.social &co identify diverse #retrons from environmental #bacteria, uncovering their defense mechanisms & using them as #GenomeEditing tools @plosbiology.org 🧪 plos.io/4oDqRAF
Isolation of retron-bearing hosts from environmental samples. Top: Schematic of the isolation of bacteria from soil and water samples and identification of possible retron-bearing hosts using PAGE analysis (from left). Retron RT-DNA bands from PAGE analyses. Overview of sampling, screening of colonies, and identification of retron hosts. Hosts displaying an RT-DNA band were subjected to whole-genome sequencing. RT-DNA was subjected to unbiased adapter addition and sequencing. Bottom: Top left panel: Schematic of canonical retron operon with components annotated, effector in pink, noncoding RNA (ncRNA) in orange, and reverse transcriptase in purple. Other seven panels: Seven putative retron operons, identifying the retron type, host species, and predicted two-dimensional structure of the ncRNA. For retrons where RT-DNA sequencing is available, sequencing coverage is plotted onto ncRNA in an orange heatmap (heatmap legend indicated number of sequencing reads mapped). Gene abbreviations: NDT (nucleoside deoxyribosyltransferase-like); PRTase (phosphoribosyltransferase); WH (winged helix-turn-helix DNA binding); HTH (helix-turn-helix domain containing); HipA (HipA-like); DUF (DUF3037 domain-containing protein).
October 24, 2025 at 12:58 PM
mapjournals.bsky.social
#TropicalPlants
CRISPR/Cas9 edits cassava genome to boost starch quality, cyanide detox & disease resistance! Challenges & advanced tools like base/prime editing explored.
Details: https://maxapress.com/article/doi/10.48130/tp-0024-0046
#CassavaBreeding #GenomeEditing
October 23, 2025 at 7:07 AM
arli.bsky.social
🚀 New Release Alert! 🚀

Discover “CRISPR Technologies – Advances in Genome Editing, Applications, and Ethical Implications” – now available!

🔗 intechopen.com/books/1004867

📚 Read, share, and join the conversation: #CRISPR #GenomeEditing #Bioethics #Biotechnology #OpenAccess
CRISPR Technologies - Advances in Genome Editing, Applications, and Ethical Implications | IntechOpen
<i>CRISPR Technologies – Advances in Genome Editing, Applications, and Ethical Implications</i> provides a comprehensive overview of one of the most revolutionary tools in contemporary biotechnology. ...
intechopen.com
October 22, 2025 at 11:04 PM
caitlyncardetti.bsky.social
Reminder since it's #WorldCRISPRDay
#GenomeEditing #CRISPR #BMCBiology
🧪 🧬 ✂️
caitlyncardetti.bsky.social Caitlyn Cardetti, PhD @caitlyncardetti.bsky.social · Sep 18
📢Call for papers: Genome editing📢
#BMCBiology
Submission Deadline: 15 June 2026

Guest Editors:
Karim Benabdellah El Khlanji, GENyO
Stanislaus Antony Ceasar, Rajagiri College of Social Sciences
Yonglun Luo, Aarhus University

Details: www.biomedcentral.com/collections/...

🧬✂️🧬✂️🧬✂️
An AI generated image of a hand cutting DNA with surgical scissors
October 20, 2025 at 7:02 PM
innovativegenomics.bsky.social
We're excited to help launch the inaugural Gordon Research Conference on #microbiome #GenomeEditing, coming up in January in Pomona, CA! Learn more and register here: https://ow.ly/63z150X9XkG
decorative illustration
October 16, 2025 at 3:05 PM
basispointinsight.bsky.social
3/3 And is India ready to lead in agri-innovation through science that edits — not imports — the future?

Read G. Chandrashekhar’s analysis for BasisPoint 👇

#GenomeEditing #CRISPR #RiceRevolution #AgriInnovation #ClimateSmartFarming #AgTech #IndiaAgriculture
BasisPointInsight.com - Genome Editing: A Quiet Revolution in Indian Rice Fields by G. Chandrashekhar
Indian scientists are quietly rewriting the genetic code of rice. Early field trials of genome-edited varieties promise higher yields, lower input use, and greater resilience to climate stress. by G. ...
basispointinsight.com
October 16, 2025 at 12:24 PM
lucapinello.bsky.social
📅 OCT 16 | 2:30-4:30 PM | Poster 6020T
I'll be at my poster: "CRISPRlungo: Accurate Quantification of Genome Editing Events from Long Reads"
Come chat about long-read sequencing & CRISPR! #GenomeEditing #LongReads #ASHG2025
October 15, 2025 at 1:41 PM
genomics-daily.bsky.social
🧬 CRISPR breakthrough! Single gene therapy slashes TTR protein by 90%, offering hope for hereditary amyloidosis patients. Precision medicine just leveled up! 🚀 #GenomeEditing #PrecisionMedicine #MedicalInnovation https://emmecola.github.io/genomics-daily
October 10, 2025 at 6:34 AM
genomejournal.bsky.social
🌱 Why do some plants resist micropropagation + transformation? New #review explores epigenetic factors driving recalcitrance—and how tools like CRISPR may help overcome these barriers.
🔗 doi.org/10.1139/gen-...
#PlantScience #Biotech #GenomeEditing
Canadian Science Publishing
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doi.org
October 9, 2025 at 1:24 PM
csbj.org
🔗 Influence of PARP1 on CRISPR/Cas9 induced double strand break repair in proliferating cells. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#CRISPR #GenomeEditing #Genomics #DNARepair #PARP1 #GeneticEngineering #MolecularBiology #GeneTherapy
Influence of PARP1 on CRISPR/Cas9 induced double strand break repair in proliferating cells. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.001
October 8, 2025 at 11:14 PM
gltch.io
✨Scientists crafted proteins to *supercharge* genome editing! 🧬 More efficient than nature itself—unlocking new possibilities for human health.🤯 #GenomeEditing

Source: https://phys.org/news/2025-10-generative-ai-outperform-nature-proteins.html
Generative AI can outperform nature at designing proteins to edit the genome
Researchers at Integra Therapeutics, in collaboration with the Pompeu Fabra University (UPF) Department of Medicine and Life Sciences (MELIS) and the Center for Genomic Regulation (CRG), have designed and experimentally validated new synthetic proteins that can edit the human genome more efficiently than proteins provided by nature.
phys.org
October 2, 2025 at 4:18 PM
kwsgroup.bsky.social
The Farmonaut takes a look at the use of #CRISPR #GenomeEditing in 2025; advancing the breeding of climate tolerant, disease resistant, and higher-yielding crop varieties. 🌾

farmonaut.com/news/crispr-...
CRISPR Agriculture News Today: 7 Powerful Advances In 2025
Crispr agriculture news today: Discover how CRISPR advances revolutionize crops, food security, and sustainable farming in 2025. Explore key updates now!
farmonaut.com
October 1, 2025 at 11:59 AM
physaliacourses.bsky.social
✂️🧬Introduction to CRISPR for Ecology and Evolution Studies(13–16 Oct, online)

Learn to design, implement, and analyze CRISPR-Cas9 experiments in non-model species through hands-on projects, lectures, and practical exercises
www.physalia-courses.org/courses-work...

#CRISPR #GenomeEditing #Evolution
Introduction to CRISPR for Ecology and Evolution Studies
Dates Online, 13-16 October 2025 To foster international participation, this course will be held online
www.physalia-courses.org
September 29, 2025 at 5:27 PM