Objective Premature rupture of membranes (PROM) is a common pregnancy disorder that is closely associated with structural weakening of fetal membranes. Studies have found that formyl peptide receptor…

In a groundbreaking study published in Nature Communications, researchers have unveiled a novel therapeutic strategy targeting formyl peptide receptor-1 (FPR1) to combat lethal cutaneous drug reactions (LCDRs). These life-threatening skin conditions, often triggered by adverse drug reactions, have presented significant clinical challenges due to their rapid progression and limited treatment options. The innovative approach of inhibiting FPR1-mediated cell death offers newfound hope for patients suffering from these severe dermatological emergencies.

A collaborative research group has developed a novel therapeutic candidate that may improve the prognosis of severe cutaneous adverse reactions such as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

Using viral barcode tracing to detect interactions between glioblastoma cells and non-malignant astrocytes in patient samples, investigators discovered a pathway that reduces tumour-specific immunity ...

CD14+FCN1hi macrophages highly express S100A8/S100A9, which is initiated by FPR1 signaling in severe COVID-19. An FPR1 inhibitor prevents the transcription, hetero-dimerization, and secretion of S100A...

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