#WeekendRead! #EveryCellIsAnImmuneCell! #SmartTumors. Ji Zhang &co show @cp-cell.bsky.social that tumor cells undergo ER stress under immune pressure leading to activation of nociceptive neurons which signal in draining lymph node driving immune suppression via decreased CCL5 & favoring tumor growth
Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance
Cancer cells exploit distant tissues and organs to escape immune surveillance by activating
nociceptive neurons, which remodel tumor-draining lymph nodes into an immune-suppressed
state. Blocking this...
www.cell.com
November 8, 2025 at 4:39 PM
#WeekendRead! #EveryCellIsAnImmuneCell! #SmartTumors. Ji Zhang &co show @cp-cell.bsky.social that tumor cells undergo ER stress under immune pressure leading to activation of nociceptive neurons which signal in draining lymph node driving immune suppression via decreased CCL5 & favoring tumor growth
#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!
Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion - Nature
The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...
doi.org
October 22, 2025 at 9:40 PM
#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!
#WeekendRead! #EveryCellIsAnImmuneCell! Kolter, Doring, Henneke &co show @cp-immunity.bsky.social that during development or after injury, skin sensory neurons provide TGFb & CGRP to macrophages which become neuron-associated macrophages helping nerve regeneration! doi.org/10.1016/j.im...
Redirecting
doi.org
October 18, 2025 at 7:33 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Kolter, Doring, Henneke &co show @cp-immunity.bsky.social that during development or after injury, skin sensory neurons provide TGFb & CGRP to macrophages which become neuron-associated macrophages helping nerve regeneration! doi.org/10.1016/j.im...
#WeekendRead! #MomIsAlwaysMom! #EveryCellIsAnImmuneCell! Serhan, Gaudenzio &co show @nature.com that elevated corticosterone in stressed moms alters #skin mast cells & mechanosensing #neurons causing fetal immunedysregulation & eczema after birth. doi.org/10.1038/s415...
Maternal stress triggers early-life eczema through fetal mast cell programming - Nature
Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to otherwise harmless mechanical friction after birth.
doi.org
October 11, 2025 at 3:09 PM
#WeekendRead! #MomIsAlwaysMom! #EveryCellIsAnImmuneCell! Serhan, Gaudenzio &co show @nature.com that elevated corticosterone in stressed moms alters #skin mast cells & mechanosensing #neurons causing fetal immunedysregulation & eczema after birth. doi.org/10.1038/s415...
#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation - Nature Immunology
Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s.
www.nature.com
August 23, 2025 at 4:25 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#WeekendRead! #EveryCellIsAnImmuneCell! #TollPower! Kaelberer Bohorquez &co show @nature.com that #TLR5 signaling in response to flagellin drives neuropeptide PYY release by gut colonic neuropod cells, activating vagal neurons that signal to #brain, reducing feeding via a “neurobiotic sense”!
A gut sense for a microbial pattern regulates feeding - Nature
A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.
www.nature.com
July 26, 2025 at 3:59 PM
#WeekendRead! #EveryCellIsAnImmuneCell! #TollPower! Kaelberer Bohorquez &co show @nature.com that #TLR5 signaling in response to flagellin drives neuropeptide PYY release by gut colonic neuropod cells, activating vagal neurons that signal to #brain, reducing feeding via a “neurobiotic sense”!
#WeekendRead! #EveryCellIsAnImmuneCell! Li Li Lin &co show @cp-immunity.bsky.social that vagal nerve stimulation protects against heart failure by decreasing, via NRF2 activation, monocyte-derived macrophages with TNF, hypertrophic, & profibrotic signatures!
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
http://dlvr.it/TLbc9J
t.co
June 29, 2025 at 2:53 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Li Li Lin &co show @cp-immunity.bsky.social that vagal nerve stimulation protects against heart failure by decreasing, via NRF2 activation, monocyte-derived macrophages with TNF, hypertrophic, & profibrotic signatures!
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis
https://go.nature.com/46c474I
https://go.nature.com/46c474I
Nerve-to-cancer transfer of mitochondria during cancer metastasis - Nature
A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabilities.
go.nature.com
June 25, 2025 at 11:01 PM
#WeAreWhatWeEat! #EveryCellIsAnImmuneCell! Dixit, Lee &co show @natmetabolism.nature.com that caloric restriction depletes cysteines, driving weight loss & browning of white adipose tissue via sympathetic nervous system-derived noradrenaline signaling, reversing metabolic inflammation in obese mice!
Cysteine depletion triggers adipose tissue thermogenesis and weight loss - Nature Metabolism
The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.
doi.org
June 4, 2025 at 12:24 PM
#WeAreWhatWeEat! #EveryCellIsAnImmuneCell! Dixit, Lee &co show @natmetabolism.nature.com that caloric restriction depletes cysteines, driving weight loss & browning of white adipose tissue via sympathetic nervous system-derived noradrenaline signaling, reversing metabolic inflammation in obese mice!
#WeekendRead! #EveryCellIsAnImmuneCell! @bryanyipp.bsky.social &co show @cp-immunity.bsky.social that nociceptor neurons decrease lung fibrosis by blocking VIP (vasoactive intestinal peptide) release by alveolar macrophages, preventing neutrophil recruitment & NETosis which contributes to fibrosis!
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Sensory innervation impacts several lung diseases, but whether it influences pulmonary
fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors
leads to worsening of inflamm...
www.cell.com
May 31, 2025 at 2:54 PM
#WeekendRead! #EveryCellIsAnImmuneCell! @bryanyipp.bsky.social &co show @cp-immunity.bsky.social that nociceptor neurons decrease lung fibrosis by blocking VIP (vasoactive intestinal peptide) release by alveolar macrophages, preventing neutrophil recruitment & NETosis which contributes to fibrosis!
#EveryCellIsAnImmuneCell! Cineus, Hegazy &co show @natimmunol.nature.com that during #colitis ILCs produce IL22 which drives oncostatin M #OSM signaling in intestinal #epithelial cells recruiting immune cells, exacerbating inflammation & being essential for tumorigenesis & colorectal tumor growth!
The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis - Nature Immunology
Hegazy and colleagues demonstrate that epithelial oncostatin M receptor expression drives gut inflammation and tumor formation.
www.nature.com
May 30, 2025 at 10:20 PM
#EveryCellIsAnImmuneCell! Cineus, Hegazy &co show @natimmunol.nature.com that during #colitis ILCs produce IL22 which drives oncostatin M #OSM signaling in intestinal #epithelial cells recruiting immune cells, exacerbating inflammation & being essential for tumorigenesis & colorectal tumor growth!
#WeekendRead! #EveryCellIsAnImmuneCell! Xie, Rose, Hu, Jackson &co show @cp-cell.bsky.social that cholinergic enteric neurons sense gut mechanical forces via Piezo1 to regulate intestinal peristalsis during homeostasis, exercise, & colitis, also decreasing inflammation & damage during colitis!
Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force
Expression and functional analysis define how Piezo1-dependent cholinergic responses
by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation
in mice.
www.cell.com
May 3, 2025 at 7:01 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Xie, Rose, Hu, Jackson &co show @cp-cell.bsky.social that cholinergic enteric neurons sense gut mechanical forces via Piezo1 to regulate intestinal peristalsis during homeostasis, exercise, & colitis, also decreasing inflammation & damage during colitis!
#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes
Endothelial Tgfβ1 shapes the development and functional identity of lung interstitial macrophages.
www.science.org
April 27, 2025 at 2:59 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
#EveryCellIsAnImmuneCell! @ikinglab.bsky.social @susanwestfall.bsky.social show @cp-cell.bsky.social that during elminth infections CD8 T cells sense #microbiota via MYD88 (not TCR) producing #interferon-g which signals on stromal cells recruiting neutrophils & on muscle cells avoiding dysmotility!
A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection
Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…
www.sciencedirect.com
April 22, 2025 at 7:23 PM
#EveryCellIsAnImmuneCell! @ikinglab.bsky.social @susanwestfall.bsky.social show @cp-cell.bsky.social that during elminth infections CD8 T cells sense #microbiota via MYD88 (not TCR) producing #interferon-g which signals on stromal cells recruiting neutrophils & on muscle cells avoiding dysmotility!
#EveryCellIsAnImmuneCell!! #MiniNLRP3: welcome to #Spectosis! Liu, Hu &co show @cell-cellpress.bsky.social that #complement activation drives red blood cell #RBC death by activating a miniNLRP3-ASC-caspase8 complex, causing proteolysis of b-spectrin & sustaining autoimmune hemolytic anemia!
Red blood cells undergo lytic programmed cell death involving NLRP3
Complement exposure induces programmed cell death of red blood cells due to the intracellular
activation of miniNLRP3 and caspase-8. Inhibiting NLRP3 signaling reduces cytoskeletal
damage and prevents...
dlvr.it
April 18, 2025 at 3:30 PM
#EveryCellIsAnImmuneCell!! #MiniNLRP3: welcome to #Spectosis! Liu, Hu &co show @cell-cellpress.bsky.social that #complement activation drives red blood cell #RBC death by activating a miniNLRP3-ASC-caspase8 complex, causing proteolysis of b-spectrin & sustaining autoimmune hemolytic anemia!
#WeekendRead! #LiveForever! #EveryCellIsAnImmuneCell! #InterferonsFriendsOrFoes?! Morrison &co show @pnas.org that with #aging, bone marrow arteriolar endothelial & T cells produce type I & II IFNs which can be targeted to prevent lymphoid progenitor depletion! www.pnas.org/doi/10.1073/...
Periarteriolar niches become inflamed in aging bone marrow, remodeling the stromal microenvironment and depleting lymphoid progenitors | PNAS
In early postnatal and young adult bone marrow, Leptin receptor–expressing (LepR+)
stromal cells and endothelial cells synthesize factors required ...
www.pnas.org
March 29, 2025 at 4:07 PM
#WeekendRead! #LiveForever! #EveryCellIsAnImmuneCell! #InterferonsFriendsOrFoes?! Morrison &co show @pnas.org that with #aging, bone marrow arteriolar endothelial & T cells produce type I & II IFNs which can be targeted to prevent lymphoid progenitor depletion! www.pnas.org/doi/10.1073/...
#WeekendRead! #EveryCellIsAnImmuneCell! Mills @fungalspore.bsky.social &co show @ Science Immunology that during lung fungal infections, lung epithelial cells independently respond to IL-1 & type III #interferons by producing GM-CSF which potentiates fungal killing by neutrophils!
GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus
During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.
www.science.org
March 23, 2025 at 3:32 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Mills @fungalspore.bsky.social &co show @ Science Immunology that during lung fungal infections, lung epithelial cells independently respond to IL-1 & type III #interferons by producing GM-CSF which potentiates fungal killing by neutrophils!
#EveryCellIsAnImmuneCell! June Round &friends show @science.org that in early life bacteria & fungi cooperate to expand insulin producing β islets via macrophage infiltration & that recognition of commensal yeast cell wall can protects against diabetes in adults! www.science.org/doi/10.1126/...
Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development
Loss of early-life microbial diversity is correlated with diabetes, yet mechanisms by which microbes influence disease remain elusive. We report a critical neonatal window in mice when microbiota disr...
www.science.org
March 12, 2025 at 5:12 PM
#EveryCellIsAnImmuneCell! June Round &friends show @science.org that in early life bacteria & fungi cooperate to expand insulin producing β islets via macrophage infiltration & that recognition of commensal yeast cell wall can protects against diabetes in adults! www.science.org/doi/10.1126/...
#WeekendRead! #EveryCellIsAnImmuneCell! Peel Zhu &co show @ Science Advances that after muscle injury, the circadian clock & hypoxia sustain glycolysis in muscle stem cells to drive CCL2 & neutrophil recruitment, facilitating muscle repair! www.science.org/doi/10.1126/...
Immunomodulatory role of the stem cell circadian clock in muscle repair
The stem cell circadian clock orchestrates metabolic and immune signaling to time muscle regeneration following injury.
www.science.org
March 8, 2025 at 7:00 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Peel Zhu &co show @ Science Advances that after muscle injury, the circadian clock & hypoxia sustain glycolysis in muscle stem cells to drive CCL2 & neutrophil recruitment, facilitating muscle repair! www.science.org/doi/10.1126/...
#EveryCellIsAnImmuneCell! @merbllan.bsky.social Goldberg &co show @nature.com that antimicrobial peptides can be produced in a cell-autonomous manner by e.g. lung epithelial cells via proteasome degradation of host proteins, protecting against lung or systemic pseudomonas infections!
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
March 6, 2025 at 6:48 PM
#EveryCellIsAnImmuneCell! @merbllan.bsky.social Goldberg &co show @nature.com that antimicrobial peptides can be produced in a cell-autonomous manner by e.g. lung epithelial cells via proteasome degradation of host proteins, protecting against lung or systemic pseudomonas infections!
#EveryCellIsAnImmuneCell! @jieyang437.bsky.social @roychoudhurilab.bsky.social &co show @nature.com that platelet-derived thromboxane A2 suppresses T cell effector functions favoring melanoma metastases! Aspirin or COX1 inhibition or deletion in platelets reduce metastasis!
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature
Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
doi.org
March 5, 2025 at 6:59 PM
#EveryCellIsAnImmuneCell! @jieyang437.bsky.social @roychoudhurilab.bsky.social &co show @nature.com that platelet-derived thromboxane A2 suppresses T cell effector functions favoring melanoma metastases! Aspirin or COX1 inhibition or deletion in platelets reduce metastasis!
#EveryCellIsAnImmuneCell! Andreas Wack & friends @crick.ac.uk discuss @annualreviews.bsky.social #Immunology the crosstalk between immune & (so called 😉) non-immune cells in #lung during inflammation, damage & repair! #MustRead doi.org/10.1146/annurev-immunol-082323-031852
The Interplay Between Innate Immunity and Nonimmune Cells in Lung Damage, Inflammation, and Repair | Annual Reviews
As the site of gas exchange, the lung is critical for organismal survival. It is also subject to continual environmental insults inflicted by pathogens, particles, and toxins. Sometimes, these insults...
doi.org
March 5, 2025 at 3:50 PM
#EveryCellIsAnImmuneCell! Andreas Wack & friends @crick.ac.uk discuss @annualreviews.bsky.social #Immunology the crosstalk between immune & (so called 😉) non-immune cells in #lung during inflammation, damage & repair! #MustRead doi.org/10.1146/annurev-immunol-082323-031852
#WeekendRead! #EveryCellIsAnImmuneCell! Cao &co show @cp-cellmetabolism.bsky.social that the sweetener aspartame aggravates atherosclerosis by inducing insulin which acts on arterial endothelial cells to drive a chemokine that recruit inflammatory myeloid cells. #ScienceSavesLives
www.cell.com
February 23, 2025 at 7:14 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Cao &co show @cp-cellmetabolism.bsky.social that the sweetener aspartame aggravates atherosclerosis by inducing insulin which acts on arterial endothelial cells to drive a chemokine that recruit inflammatory myeloid cells. #ScienceSavesLives
#EveryCellIsAnImmuneCell! El Agha Khadim &co show @cp-cellreports.bsky.social that after influenza A virus infection, a population of cells resembling developmental alveolar myofibroblasts are essential for tissue repair & are reduced in COPD, & persistently activated in non-resolving ARDS, patients
Myofibroblasts emerge during alveolar regeneration following influenza-virus-induced lung injury
Khadim et al. use mouse models to show that adult lung mesenchymal cells upregulate
the developmental alveolar myofibroblast (AMF) signature during alveolar regeneration.
They show that overactivation...
www.cell.com
February 4, 2025 at 9:27 PM
#EveryCellIsAnImmuneCell! El Agha Khadim &co show @cp-cellreports.bsky.social that after influenza A virus infection, a population of cells resembling developmental alveolar myofibroblasts are essential for tissue repair & are reduced in COPD, & persistently activated in non-resolving ARDS, patients
#EveryCellIsAnImmuneCell! Rakoff-Nahoum & Chatila labs @bostonchildrens.bsky.social @harvardmed.bsky.social show @nature.com that in food #allergy intestinal goblet cells produce RELMb which depletes #microbiota producing indole metabolites necessary to activate AHR & drive Tregs!
RELMβ sets the threshold for microbiome-dependent oral tolerance - Nature
RELMβ mediates a gut immune–epithelial circuit regulating tolerance to food antigens, offering targetable candidates for the prevention and treatment of food allergies.
www.nature.com
January 22, 2025 at 9:36 PM
#EveryCellIsAnImmuneCell! Rakoff-Nahoum & Chatila labs @bostonchildrens.bsky.social @harvardmed.bsky.social show @nature.com that in food #allergy intestinal goblet cells produce RELMb which depletes #microbiota producing indole metabolites necessary to activate AHR & drive Tregs!