Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...
PNAS www.pnas.org/doi/10.1073/...
November 11, 2025 at 11:01 PM
Just out! Our work on active transport in epithelial tissues. Congrats to Huiqiong Wu, Greg Arkowitz and Ranjith Chilupuri in collaboration with C. Duclut and J. Prost!
PNAS www.pnas.org/doi/10.1073/...
PNAS www.pnas.org/doi/10.1073/...
Specifically, we found a new IBD-specific epithelial cell type emerging the expresses PCSK6. We identified putative signaling between PCSK6⁺ epithelial cells (Kitl⁺) and Kit⁺ ILC3s, as well as upregulation of IGF1 in fibroblasts that may contribute to epithelial remodeling.
November 13, 2025 at 1:53 AM
Specifically, we found a new IBD-specific epithelial cell type emerging the expresses PCSK6. We identified putative signaling between PCSK6⁺ epithelial cells (Kitl⁺) and Kit⁺ ILC3s, as well as upregulation of IGF1 in fibroblasts that may contribute to epithelial remodeling.
Fosl2 regulates the transition from parietal epithelial cells to myofibroblasts in the kidney https://www.biorxiv.org/content/10.1101/2025.11.10.687667v1
November 12, 2025 at 8:01 PM
Fosl2 regulates the transition from parietal epithelial cells to myofibroblasts in the kidney https://www.biorxiv.org/content/10.1101/2025.11.10.687667v1
Epithelial-immune cell crosstalk involving IL-17-producing T lymphocytes and neutrophils as essential for the dysplasia-carcinoma progression @cp-cellreports.bsky.social
www.cell.com/cell-reports... @inserm.fr
www.cell.com/cell-reports... @inserm.fr
November 14, 2025 at 3:13 AM
Epithelial-immune cell crosstalk involving IL-17-producing T lymphocytes and neutrophils as essential for the dysplasia-carcinoma progression @cp-cellreports.bsky.social
www.cell.com/cell-reports... @inserm.fr
www.cell.com/cell-reports... @inserm.fr
Epithelial convergent extension as a tuning process https://www.biorxiv.org/content/10.1101/2025.11.06.687029v1
November 8, 2025 at 3:49 AM
Epithelial convergent extension as a tuning process https://www.biorxiv.org/content/10.1101/2025.11.06.687029v1
Join us tomorrow for a Night Science Seminar Series presentation! Jennifer Oyler-Yaniv from Harvard will talk about how a scientific journey can be viewed as a mythological Hero's Quest by sharing work from her lab on how epithelial tissues restrict the spread of viruses.
cassyni.com/events/ZYQow...
cassyni.com/events/ZYQow...
November 9, 2025 at 3:37 PM
Join us tomorrow for a Night Science Seminar Series presentation! Jennifer Oyler-Yaniv from Harvard will talk about how a scientific journey can be viewed as a mythological Hero's Quest by sharing work from her lab on how epithelial tissues restrict the spread of viruses.
cassyni.com/events/ZYQow...
cassyni.com/events/ZYQow...
This work highlights that chronic gut inflammation involves coordinated remodeling of both epithelial and stromal compartments, extending beyond immune cell activation to reshape tissue structure and function.
November 13, 2025 at 1:53 AM
This work highlights that chronic gut inflammation involves coordinated remodeling of both epithelial and stromal compartments, extending beyond immune cell activation to reshape tissue structure and function.
Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!
🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu
November 6, 2025 at 12:14 PM
Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!
📢 Institut Jacques Monod Seminar
📅 November 25th
📍 IJM
Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab, Magali Suzanne will present the IJM seminar « Spatio-temporal control of nuclear Mechanotransduction during Epithelial-to-Mesenchymal transition »
➡️ buff.ly/ajrwbxo
📅 November 25th
📍 IJM
Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab, Magali Suzanne will present the IJM seminar « Spatio-temporal control of nuclear Mechanotransduction during Epithelial-to-Mesenchymal transition »
➡️ buff.ly/ajrwbxo
November 13, 2025 at 10:08 AM
📢 Institut Jacques Monod Seminar
📅 November 25th
📍 IJM
Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab, Magali Suzanne will present the IJM seminar « Spatio-temporal control of nuclear Mechanotransduction during Epithelial-to-Mesenchymal transition »
➡️ buff.ly/ajrwbxo
📅 November 25th
📍 IJM
Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab, Magali Suzanne will present the IJM seminar « Spatio-temporal control of nuclear Mechanotransduction during Epithelial-to-Mesenchymal transition »
➡️ buff.ly/ajrwbxo
New data on #mitochondria Aminoacyl-#tRNASynthetase, DARS2, reports secretion by #airway #epithelial cells in response to #TNFα, and a role in #paracrine signaling resulting in M1 #macrophage like phenotype in recipient THP1 cells.
doi.org/10.14814/phy...
doi.org/10.14814/phy...
November 13, 2025 at 10:15 AM
New data on #mitochondria Aminoacyl-#tRNASynthetase, DARS2, reports secretion by #airway #epithelial cells in response to #TNFα, and a role in #paracrine signaling resulting in M1 #macrophage like phenotype in recipient THP1 cells.
doi.org/10.14814/phy...
doi.org/10.14814/phy...
"Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus"
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus - PubMed
P. melaninogenica enhanced neutrophil and epithelial defense against S. aureus, but the benefits of epithelial cell regulation by P. melaninogenica were lost with CFTR dysfunction. CFTR modulators rescued P. melaninogenica responsiveness in epithelial cells, highlighting the potential for synergisti …
pubmed.ncbi.nlm.nih.gov
November 7, 2025 at 12:38 PM
"Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus"
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
Check out this Review for our Special Issue from Rachael Dangarembizi, Amalia Awala & Anja de Lange from the University of Capetown on #neuroinflammation during #fungal infection, which is an essential host defence but also contributes to neuropathology
journals.biologists.com/dmm/article/...
journals.biologists.com/dmm/article/...
November 11, 2025 at 2:45 PM
Check out this Review for our Special Issue from Rachael Dangarembizi, Amalia Awala & Anja de Lange from the University of Capetown on #neuroinflammation during #fungal infection, which is an essential host defence but also contributes to neuropathology
journals.biologists.com/dmm/article/...
journals.biologists.com/dmm/article/...
Our #JCSciliaSI is complete
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image shows tracheal epithelial cells from an air-liquid interface culture imaged using U-ExM from Oliver Mercey and Marine Brunet @centriolelab.bsky.social.
journals.biologists.com/jcs/article/...
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image shows tracheal epithelial cells from an air-liquid interface culture imaged using U-ExM from Oliver Mercey and Marine Brunet @centriolelab.bsky.social.
journals.biologists.com/jcs/article/...
November 4, 2025 at 1:36 PM
Our #JCSciliaSI is complete
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image shows tracheal epithelial cells from an air-liquid interface culture imaged using U-ExM from Oliver Mercey and Marine Brunet @centriolelab.bsky.social.
journals.biologists.com/jcs/article/...
Explore our ToC: journals.biologists.com/jcs/issue/13...
Our cover image shows tracheal epithelial cells from an air-liquid interface culture imaged using U-ExM from Oliver Mercey and Marine Brunet @centriolelab.bsky.social.
journals.biologists.com/jcs/article/...
Aurélia Joly, @micro-megs.bsky.social & co show that stem cell-intrinsic NF-κB activity is crucial for preventing apoptosis and ensuring proper intestinal epithelial repair following injury in #Drosophila. 🪰
doi.org/10.1242/bio....
#StemCells #Intestine
doi.org/10.1242/bio....
#StemCells #Intestine
November 5, 2025 at 10:08 AM
Aurélia Joly, @micro-megs.bsky.social & co show that stem cell-intrinsic NF-κB activity is crucial for preventing apoptosis and ensuring proper intestinal epithelial repair following injury in #Drosophila. 🪰
doi.org/10.1242/bio....
#StemCells #Intestine
doi.org/10.1242/bio....
#StemCells #Intestine
Happy #MicroscopyMonday everyone!🔬🌟Nic has taken a cross-section image of the retina under the microscope: red shows the Retinal Pigment Epithelial cells, orange shows photoreceptor cell bodies with cilia & green shows the outer nuclear layer with just photoreceptor cell bodies 👁️✨
#neuroskyence
#neuroskyence
November 3, 2025 at 9:01 AM
Happy #MicroscopyMonday everyone!🔬🌟Nic has taken a cross-section image of the retina under the microscope: red shows the Retinal Pigment Epithelial cells, orange shows photoreceptor cell bodies with cilia & green shows the outer nuclear layer with just photoreceptor cell bodies 👁️✨
#neuroskyence
#neuroskyence
Renal tubular epithelial cell cast (Sternheimer-Malbin stain) under 1000x bright field. Pt with nephrotic range proteinuria, suspected GN. Note small lipid droplets on most inferior cell in the cast.
November 1, 2025 at 6:42 PM
Renal tubular epithelial cell cast (Sternheimer-Malbin stain) under 1000x bright field. Pt with nephrotic range proteinuria, suspected GN. Note small lipid droplets on most inferior cell in the cast.
Interested in polarity and mechanics during epithelial morphogenesis? Considering joining us! Students to be hired initially as Research Associates. Postdocs encouraged to obtain fellowship, and we help/train you to do that. Apply to tinyurl.com/y6x489t5. Deadline Dec 15.
Please repost!
Please repost!
November 3, 2025 at 1:53 AM
Interested in polarity and mechanics during epithelial morphogenesis? Considering joining us! Students to be hired initially as Research Associates. Postdocs encouraged to obtain fellowship, and we help/train you to do that. Apply to tinyurl.com/y6x489t5. Deadline Dec 15.
Please repost!
Please repost!
„Training of aging: Epithelial memory at the crossroads“. This is the title of Prof. Weckmann's lecture, which he will be giving for RESIST at the MHH on 6 November from 1 to 2 pm. Come in large numbers!
www.resist-cluster.de/veranstaltun...
www.resist-cluster.de/veranstaltun...
RESIST-Seminar Gastvortrag von Prof. Markus Weckmann
Spannende Themen, interessant präsentiert: Jeden ersten und dritten Donnerstag (außer während der Schulferien) stellen RESIST-Wissenschaftlerinnen oder -Wissenschaftler oder hochkarätige Forscherinnen...
www.resist-cluster.de
November 3, 2025 at 2:52 PM
„Training of aging: Epithelial memory at the crossroads“. This is the title of Prof. Weckmann's lecture, which he will be giving for RESIST at the MHH on 6 November from 1 to 2 pm. Come in large numbers!
www.resist-cluster.de/veranstaltun...
www.resist-cluster.de/veranstaltun...
Mechanisms underpinning spontaneous spinal cord regeneration
In their #LifelongDevSI Review, Amruta Tendolkar and Mayssa H. Mokalled discuss how immune responses, pro-regenerative glial cell reactivity and multimodal neuronal repair direct innate spinal cord repair
doi.org/10.1242/dev....
In their #LifelongDevSI Review, Amruta Tendolkar and Mayssa H. Mokalled discuss how immune responses, pro-regenerative glial cell reactivity and multimodal neuronal repair direct innate spinal cord repair
doi.org/10.1242/dev....
October 29, 2025 at 4:17 PM
Mechanisms underpinning spontaneous spinal cord regeneration
In their #LifelongDevSI Review, Amruta Tendolkar and Mayssa H. Mokalled discuss how immune responses, pro-regenerative glial cell reactivity and multimodal neuronal repair direct innate spinal cord repair
doi.org/10.1242/dev....
In their #LifelongDevSI Review, Amruta Tendolkar and Mayssa H. Mokalled discuss how immune responses, pro-regenerative glial cell reactivity and multimodal neuronal repair direct innate spinal cord repair
doi.org/10.1242/dev....
The cellular protease TMPRSS2 cleaves and activates the SARS-CoV-2 spike protein, priming it for membrane fusion and viral entry.
This step is essential for efficient infection of airway epithelial cells.
This step is essential for efficient infection of airway epithelial cells.
October 27, 2025 at 10:11 PM
The cellular protease TMPRSS2 cleaves and activates the SARS-CoV-2 spike protein, priming it for membrane fusion and viral entry.
This step is essential for efficient infection of airway epithelial cells.
This step is essential for efficient infection of airway epithelial cells.
#Research
Epithelial cells use electricity to detect and eliminate energy-deficient neighbouring cells ⚡🧫
🪫 The mechanical forces of energy-deficient cells activate an electrical sodium current that depolarises the membrane and triggers cell extrusion.
👉 tuit.cat/ve6CE
Epithelial cells use electricity to detect and eliminate energy-deficient neighbouring cells ⚡🧫
🪫 The mechanical forces of energy-deficient cells activate an electrical sodium current that depolarises the membrane and triggers cell extrusion.
👉 tuit.cat/ve6CE
October 28, 2025 at 7:55 AM
#Research
Epithelial cells use electricity to detect and eliminate energy-deficient neighbouring cells ⚡🧫
🪫 The mechanical forces of energy-deficient cells activate an electrical sodium current that depolarises the membrane and triggers cell extrusion.
👉 tuit.cat/ve6CE
Epithelial cells use electricity to detect and eliminate energy-deficient neighbouring cells ⚡🧫
🪫 The mechanical forces of energy-deficient cells activate an electrical sodium current that depolarises the membrane and triggers cell extrusion.
👉 tuit.cat/ve6CE
🎓 Congratulations to Mathieu Joseph on successfully defending his PhD thesis entitled: “Slik kinase regulates epithelial integrity and cytoneme formation during Drosophila wing disc morphogenesis under the control of the STRIPAK complex”👏
October 27, 2025 at 8:07 PM
🎓 Congratulations to Mathieu Joseph on successfully defending his PhD thesis entitled: “Slik kinase regulates epithelial integrity and cytoneme formation during Drosophila wing disc morphogenesis under the control of the STRIPAK complex”👏
New preprint out! 📣🚨
We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠
#Microsky
We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠
#Microsky
Carbapenem-resistance oprD mutations reshape Pseudomonas aeruginosa host-pathogen interactions during infection https://www.biorxiv.org/content/10.1101/2025.10.24.684370v1
October 25, 2025 at 12:29 PM
New preprint out! 📣🚨
We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠
#Microsky
We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠
#Microsky
Early cell autonomous and niche-mediated alveolar epithelial response to influenza infection in primary lung organoids https://www.biorxiv.org/content/10.1101/2025.10.24.684481v1
October 26, 2025 at 3:04 AM
Early cell autonomous and niche-mediated alveolar epithelial response to influenza infection in primary lung organoids https://www.biorxiv.org/content/10.1101/2025.10.24.684481v1
"Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling" spkl.io/63321Ak5x1
Sung-Jan Lin & colleagues
@cp-cellmetabolism.bsky.social
Sung-Jan Lin & colleagues
@cp-cellmetabolism.bsky.social
October 24, 2025 at 9:00 PM
"Adipocyte lipolysis activates epithelial stem cells for hair regeneration through fatty acid metabolic signaling" spkl.io/63321Ak5x1
Sung-Jan Lin & colleagues
@cp-cellmetabolism.bsky.social
Sung-Jan Lin & colleagues
@cp-cellmetabolism.bsky.social