A startup founded by former Meta researchers is creating an alternative evolutionary path using the most powerful computational resources ever applied in biology. Scientists trained ESM3 to generate a new GFP, and the result surprised them: a fluorescent protein.
english.elpais.com/science-tech...
english.elpais.com/science-tech...
AI simulates 500 million years of evolution to discover artificial fluorescent protein
A startup founded by former Meta researchers is creating an alternative evolutionary path using the most powerful computational resources ever applied in biology, according to the company
english.elpais.com
January 21, 2025 at 6:59 PM
A startup founded by former Meta researchers is creating an alternative evolutionary path using the most powerful computational resources ever applied in biology. Scientists trained ESM3 to generate a new GFP, and the result surprised them: a fluorescent protein.
english.elpais.com/science-tech...
english.elpais.com/science-tech...
Developing Earth System Models is essential for climate research as they are to represent more components of the Earth System than climate models of lower complexity. However, it is not an easy task! Dr. Jan Streffing, the developer of AWI-CM3, will show at #EGU25 the work of building AWI-ESM3.
May 1, 2025 at 11:54 AM
Developing Earth System Models is essential for climate research as they are to represent more components of the Earth System than climate models of lower complexity. However, it is not an easy task! Dr. Jan Streffing, the developer of AWI-CM3, will show at #EGU25 the work of building AWI-ESM3.
Eternal life to approach soon. The startup EvolutionaryScale recently unveiled its ESM3 GenAI Model for Advanced Protein Design.
#GenAI #bioscience #aws
www.biopharmatrend.com/post/837-evo...
#GenAI #bioscience #aws
www.biopharmatrend.com/post/837-evo...
EvolutionaryScale Unveils ESM3 Generative AI Model for Advanced Protein Design
www.biopharmatrend.com
July 14, 2024 at 9:35 AM
Eternal life to approach soon. The startup EvolutionaryScale recently unveiled its ESM3 GenAI Model for Advanced Protein Design.
#GenAI #bioscience #aws
www.biopharmatrend.com/post/837-evo...
#GenAI #bioscience #aws
www.biopharmatrend.com/post/837-evo...
ESM3 Model: Writing New Proteins for the Future
rockymountainatheists.ca/post/esm3-mo...
#RockyMountainAtheists #rma #WesternCanadaReason #wecanreason #freedomfromreligion #criticalthinking #skeptics #science #ESM3model #syntheticbiology #proteincreation #innovation #research
rockymountainatheists.ca/post/esm3-mo...
#RockyMountainAtheists #rma #WesternCanadaReason #wecanreason #freedomfromreligion #criticalthinking #skeptics #science #ESM3model #syntheticbiology #proteincreation #innovation #research
ESM3 Model: Writing New Proteins for the Future - Rocky Mountain Atheists
The ESM3 model revolutionizes synthetic biology by enabling the creation of new proteins from scratch. This breakthrough opens up endless possibilities for the field, paving the way for innovative app...
rockymountainatheists.ca
July 18, 2024 at 5:21 PM
ESM3 Model: Writing New Proteins for the Future
rockymountainatheists.ca/post/esm3-mo...
#RockyMountainAtheists #rma #WesternCanadaReason #wecanreason #freedomfromreligion #criticalthinking #skeptics #science #ESM3model #syntheticbiology #proteincreation #innovation #research
rockymountainatheists.ca/post/esm3-mo...
#RockyMountainAtheists #rma #WesternCanadaReason #wecanreason #freedomfromreligion #criticalthinking #skeptics #science #ESM3model #syntheticbiology #proteincreation #innovation #research
The successful design of a distant functional fluorescent protein highlights how AI can expand our reach in protein engineering.
However, it's important to distinguish this from modeling biological evolution.
ESM3 does not "reason", it mimicks learned patterns, like GPT4 does for language.
/fin
However, it's important to distinguish this from modeling biological evolution.
ESM3 does not "reason", it mimicks learned patterns, like GPT4 does for language.
/fin
January 16, 2025 at 8:34 PM
The successful design of a distant functional fluorescent protein highlights how AI can expand our reach in protein engineering.
However, it's important to distinguish this from modeling biological evolution.
ESM3 does not "reason", it mimicks learned patterns, like GPT4 does for language.
/fin
However, it's important to distinguish this from modeling biological evolution.
ESM3 does not "reason", it mimicks learned patterns, like GPT4 does for language.
/fin
ESM3 structure predictions for multimers seem to be broken: In our (preliminary) experiments, it seems to always predict chain breaks around one amino acid in length.
ESM 3 chain break token may be broken. (1/4)
Predicted structure of insulin (red). An NMR structure (PDB:1A7F, green). The chain break token distance is 3.4A while the experimentally determined distance is 18.9A.
sequence prompt:
"GIVEQCCTSICSLYQLENYCN|FVNQHLCGSHLVEALELVCGERGGFYTPK"
Predicted structure of insulin (red). An NMR structure (PDB:1A7F, green). The chain break token distance is 3.4A while the experimentally determined distance is 18.9A.
sequence prompt:
"GIVEQCCTSICSLYQLENYCN|FVNQHLCGSHLVEALELVCGERGGFYTPK"
December 12, 2024 at 2:26 PM
ESM3 structure predictions for multimers seem to be broken: In our (preliminary) experiments, it seems to always predict chain breaks around one amino acid in length.
Weekly Recap (March 2025, part 1) Heritable polygenic editing, self-supervised learning in single-cell genomics, predictive modeling with tabular foundation models, ESM3, pangenome graphs in biodiversity genomics, ... doi.org/10.59350/7wy... 🧬🖥️🧪
March 21, 2025 at 11:07 AM
Weekly Recap (March 2025, part 1) Heritable polygenic editing, self-supervised learning in single-cell genomics, predictive modeling with tabular foundation models, ESM3, pangenome graphs in biodiversity genomics, ... doi.org/10.59350/7wy... 🧬🖥️🧪
In a new Science study, researchers present ESM3, a protein language model that enables the programmed generation of protein structure and sequence in response to user prompts.
Learn more: scim.ag/40l2z3J
Learn more: scim.ag/40l2z3J
Simulating 500 million years of evolution with a language model
More than 3 billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here, we show that language models trained at scale on evolutionary data can genera...
scim.ag
February 26, 2025 at 8:08 PM
In a new Science study, researchers present ESM3, a protein language model that enables the programmed generation of protein structure and sequence in response to user prompts.
Learn more: scim.ag/40l2z3J
Learn more: scim.ag/40l2z3J
ESM3 is trying to do that.
December 1, 2024 at 2:24 PM
ESM3 is trying to do that.
August 23, 2024 at 10:09 PM
Question about protein LMs that compress/predict structure w/ tokens (examples incl FoldToken3, Foldseek, ESM3, etc), can any represent/predict/account for multimers or small molecules? Havent seen any developments in that direction but not following as closely as I used to
September 13, 2024 at 3:35 PM
Question about protein LMs that compress/predict structure w/ tokens (examples incl FoldToken3, Foldseek, ESM3, etc), can any represent/predict/account for multimers or small molecules? Havent seen any developments in that direction but not following as closely as I used to
🛰️🌑 Le troisième module de service européen #ESM3 du vaisseau lunaire #Orion vient de quitter les installations d'Airbus Space à Brême en Allemagne.
Le conteneur va prendre le bateau Canopé d’ArianeGroup pour rejoindre le Centre spatial Kennedy de la NASA en Floride.
📷 Airbus DS GmbH 2024
Le conteneur va prendre le bateau Canopé d’ArianeGroup pour rejoindre le Centre spatial Kennedy de la NASA en Floride.
📷 Airbus DS GmbH 2024
August 23, 2024 at 10:30 AM
We just updated our manuscript "Understanding Language Model Scaling on Protein Fitness Prediction". Where we explained why larger pLMs don’t always perform better on mutation effect prediction. We extended beyond ESM2 to models like ESMC, ESM3, SaProt, and ESM-IF1.
#ProteinLM
#ProteinLM
August 25, 2025 at 2:25 AM
We just updated our manuscript "Understanding Language Model Scaling on Protein Fitness Prediction". Where we explained why larger pLMs don’t always perform better on mutation effect prediction. We extended beyond ESM2 to models like ESMC, ESM3, SaProt, and ESM-IF1.
#ProteinLM
#ProteinLM
EvolutionaryScale’s #AI model #ESM3 just created a glowing molecule that scientists estimate would've taken HALF A BILLION YEARS to evolve naturally! 🤯 That's mind-blowing. Makes you wonder what else AI can cook up. Is this the future of discovery? 🤔 #Science #ProteinEngineering #ResearchSky
New glowing molecule, invented by AI, would have taken 500 million years to evolve in nature, scientists say
An artificial intelligence model has created a new protein that researchers say would have taken 500 million years to evolve in nature — if nature were capable of producing such a thing.
www.livescience.com
January 29, 2025 at 1:06 PM
EvolutionaryScale’s #AI model #ESM3 just created a glowing molecule that scientists estimate would've taken HALF A BILLION YEARS to evolve naturally! 🤯 That's mind-blowing. Makes you wonder what else AI can cook up. Is this the future of discovery? 🤔 #Science #ProteinEngineering #ResearchSky
não é tão difícil quanto parece
bsky.app/profile/esm3...
bsky.app/profile/esm3...
Eu não sou multi instrumentista e geralmente eu odeio o resultado da maioria das minhas gravações que eu toco qualquer coisa que não seja piano. Só que tô achando muito bom o resultado do baixo nessa música que eu comecei a gravar ontem, até parece que eu sei o que eu tô fazendo..
July 6, 2025 at 10:48 PM
não é tão difícil quanto parece
bsky.app/profile/esm3...
bsky.app/profile/esm3...
structural change and suggests that ESM3's accuracy might be approaching a limit within its pre-trained space. (pg. 5)
December 10, 2024 at 4:40 AM
structural change and suggests that ESM3's accuracy might be approaching a limit within its pre-trained space. (pg. 5)
More Structures, Less Accuracy: ESM3's Binding Prediction Paradox[new]
This paper explores how using structural info affects protein-protein interaction predictions by the multimodal protein language model ESM3. They use different structural variants and structure pipelines (EvoEF2, ...
This paper explores how using structural info affects protein-protein interaction predictions by the multimodal protein language model ESM3. They use different structural variants and structure pipelines (EvoEF2, ...
December 10, 2024 at 4:39 AM
More Structures, Less Accuracy: ESM3's Binding Prediction Paradox[new]
This paper explores how using structural info affects protein-protein interaction predictions by the multimodal protein language model ESM3. They use different structural variants and structure pipelines (EvoEF2, ...
This paper explores how using structural info affects protein-protein interaction predictions by the multimodal protein language model ESM3. They use different structural variants and structure pipelines (EvoEF2, ...
An #AI model created to design proteins simulates 500 million years of protein evolution in developing a previously unknown bright fluorescent protein.
Learn more in a new Science study: https://scim.ag/40l2z3J
Learn more in a new Science study: https://scim.ag/40l2z3J
January 17, 2025 at 3:07 PM
An #AI model created to design proteins simulates 500 million years of protein evolution in developing a previously unknown bright fluorescent protein.
Learn more in a new Science study: https://scim.ag/40l2z3J
Learn more in a new Science study: https://scim.ag/40l2z3J
In a groundbreaking advancement, researchers have harnessed the power of the ESM3 AI model to simulate 500 million years of evolutionary history, resulting in the creation of ...
🔗 Source: https://naseba.sk/uncategorised/10783/revolutionizing-science-in-a-flash-new-proteins-created-with-ai-magic/
🔗 Source: https://naseba.sk/uncategorised/10783/revolutionizing-science-in-a-flash-new-proteins-created-with-ai-magic/
October 1, 2025 at 5:40 AM
In a groundbreaking advancement, researchers have harnessed the power of the ESM3 AI model to simulate 500 million years of evolutionary history, resulting in the creation of ...
🔗 Source: https://naseba.sk/uncategorised/10783/revolutionizing-science-in-a-flash-new-proteins-created-with-ai-magic/
🔗 Source: https://naseba.sk/uncategorised/10783/revolutionizing-science-in-a-flash-new-proteins-created-with-ai-magic/
ESM3 protein language model has been released:
www.evolutionaryscale.ai/blog/esm3-re...
Github:
github.com/evolutionary...
(non-commercial license only)
www.evolutionaryscale.ai/blog/esm3-re...
Github:
github.com/evolutionary...
(non-commercial license only)
Evolutionary Scale · ESM3: Simulating 500 million years of evolution with a language model
www.evolutionaryscale.ai
June 25, 2024 at 9:46 PM
ESM3 protein language model has been released:
www.evolutionaryscale.ai/blog/esm3-re...
Github:
github.com/evolutionary...
(non-commercial license only)
www.evolutionaryscale.ai/blog/esm3-re...
Github:
github.com/evolutionary...
(non-commercial license only)
2024年研究5(再掲)
内容：MRIと経験サンプリング法の実験
対象：18〜50歳
日程：4/15~10/1
所要時間：MRI1hx2+ESM3週間
謝礼：9000円
場所：オンラインと理研和光
参加は以下サイトより
www.jikken-baito.com
内容：MRIと経験サンプリング法の実験
対象：18〜50歳
日程：4/15~10/1
所要時間：MRI1hx2+ESM3週間
謝礼：9000円
場所：オンラインと理研和光
参加は以下サイトより
www.jikken-baito.com
April 2, 2024 at 2:10 AM
2024年研究5(再掲)
内容：MRIと経験サンプリング法の実験
対象：18〜50歳
日程：4/15~10/1
所要時間：MRI1hx2+ESM3週間
謝礼：9000円
場所：オンラインと理研和光
参加は以下サイトより
www.jikken-baito.com
内容：MRIと経験サンプリング法の実験
対象：18〜50歳
日程：4/15~10/1
所要時間：MRI1hx2+ESM3週間
謝礼：9000円
場所：オンラインと理研和光
参加は以下サイトより
www.jikken-baito.com
ESM3, a protein language model, generates functional proteins beyond known ones. It created a bright fluorescent protein, 58% different from existing ones, simulating 500 million years of evolution. An example of using LLMs for good.
www.ethicalpsychology.com/2025/03/simu...
www.ethicalpsychology.com/2025/03/simu...
Simulating 500 million years of evolution with a language model
Find information and research on ethics, psychology, decision-making, AI, morality, ethical decision-making for mental health practitioners.
www.ethicalpsychology.com
March 28, 2025 at 9:44 AM
ESM3, a protein language model, generates functional proteins beyond known ones. It created a bright fluorescent protein, 58% different from existing ones, simulating 500 million years of evolution. An example of using LLMs for good.
www.ethicalpsychology.com/2025/03/simu...
www.ethicalpsychology.com/2025/03/simu...
New Giant Protein Language Model
EvolutionaryScale, a frontier #Al research lab, has unveiled ESM3, a groundbreaking generative Al model for protein design that simulates millions of years of evolution to create novel proteins
www.perplexity.ai/page/new-gia...
#Science #Biology
EvolutionaryScale, a frontier #Al research lab, has unveiled ESM3, a groundbreaking generative Al model for protein design that simulates millions of years of evolution to create novel proteins
www.perplexity.ai/page/new-gia...
#Science #Biology
New Giant Protein Language Model
EvolutionaryScale, a frontier AI research lab, has unveiled ESM3, a groundbreaking generative AI model for protein design that simulates millions of years of...
www.perplexity.ai
July 14, 2024 at 6:59 AM
New Giant Protein Language Model
EvolutionaryScale, a frontier #Al research lab, has unveiled ESM3, a groundbreaking generative Al model for protein design that simulates millions of years of evolution to create novel proteins
www.perplexity.ai/page/new-gia...
#Science #Biology
EvolutionaryScale, a frontier #Al research lab, has unveiled ESM3, a groundbreaking generative Al model for protein design that simulates millions of years of evolution to create novel proteins
www.perplexity.ai/page/new-gia...
#Science #Biology
3) I've had the amazing fortune to work both on AlphaFold (www.nature.com/articles/s41...) and ESM3 (www.biorxiv.org/content/10.1...), where I contributed to both models. This is only the beginning of ML integration to the wet lab not just in protein design.
Thrilled to connect w/ ppl here!
3/3
Thrilled to connect w/ ppl here!
3/3
November 15, 2024 at 2:22 AM
3) I've had the amazing fortune to work both on AlphaFold (www.nature.com/articles/s41...) and ESM3 (www.biorxiv.org/content/10.1...), where I contributed to both models. This is only the beginning of ML integration to the wet lab not just in protein design.
Thrilled to connect w/ ppl here!
3/3
Thrilled to connect w/ ppl here!
3/3