"The papermill crisis is not an external attack on science but a mirror held up to its dysfunctional ecosystem. The for-profit publishing industry, posing as a newly found saviour of research integrity, is in fact its chief beneficiary and enabler."
November 17, 2025 at 8:31 AM
"The papermill crisis is not an external attack on science but a mirror held up to its dysfunctional ecosystem. The for-profit publishing industry, posing as a newly found saviour of research integrity, is in fact its chief beneficiary and enabler."
particularly involving the brainstem and its regulatory functions
- The similarity in symptoms and underlying mechanisms supports the concept of a shared dysfunctional CNS-immune interface, with the brainstem playing a central role in mediating these interactions
- The similarity in symptoms and underlying mechanisms supports the concept of a shared dysfunctional CNS-immune interface, with the brainstem playing a central role in mediating these interactions
November 17, 2025 at 8:14 AM
particularly involving the brainstem and its regulatory functions
- The similarity in symptoms and underlying mechanisms supports the concept of a shared dysfunctional CNS-immune interface, with the brainstem playing a central role in mediating these interactions
- The similarity in symptoms and underlying mechanisms supports the concept of a shared dysfunctional CNS-immune interface, with the brainstem playing a central role in mediating these interactions
🔑 Pathological Feedback Loops & Disease Persistence
- after an initial infection or stressor, systemic pathology may reach the brain via neurovascular pathways or a dysfunctional blood-brain barrier, resulting in chronic neuroinflammation centered on the brainstem.
- after an initial infection or stressor, systemic pathology may reach the brain via neurovascular pathways or a dysfunctional blood-brain barrier, resulting in chronic neuroinflammation centered on the brainstem.
November 17, 2025 at 8:07 AM
🔑 Pathological Feedback Loops & Disease Persistence
- after an initial infection or stressor, systemic pathology may reach the brain via neurovascular pathways or a dysfunctional blood-brain barrier, resulting in chronic neuroinflammation centered on the brainstem.
- after an initial infection or stressor, systemic pathology may reach the brain via neurovascular pathways or a dysfunctional blood-brain barrier, resulting in chronic neuroinflammation centered on the brainstem.
S*E is chronically dysfunctional, they've never been well run. They announced they were getting into NFTs at the exact moment everyone else started backing out. They insist that a game isn't successful unless it beats the stock market. They released The Quiet Man.
November 17, 2025 at 8:06 AM
S*E is chronically dysfunctional, they've never been well run. They announced they were getting into NFTs at the exact moment everyone else started backing out. They insist that a game isn't successful unless it beats the stock market. They released The Quiet Man.
These immune abnormalities are linked to neuroinflammation and are thought to be sustained by aberrant signaling from deformed or dysfunctional brainstem nuclei . In both conditions, neuroinflammation involving the brainstem as a central mechanism. Sustained glial activation (microglia & astrocytes)
November 17, 2025 at 8:04 AM
These immune abnormalities are linked to neuroinflammation and are thought to be sustained by aberrant signaling from deformed or dysfunctional brainstem nuclei . In both conditions, neuroinflammation involving the brainstem as a central mechanism. Sustained glial activation (microglia & astrocytes)
Great report on a huge problem for #Eastbourne: a dysfunctional & chronically underinvested wastewater treatment works. The recent massive spill of millions of toxic bio-beads from the plant is the worst single pollution incident so far, seriously contaminating local waters, beaches, & wildlife.
Scathing verdicts from residents about how Southern Water has dealt with the long-running problem of smell from a water treatment works
Then there are the plastic beads polluting beautiful Camber Sands
I turned up and asked questions
#journalism #eastbourne
Then there are the plastic beads polluting beautiful Camber Sands
I turned up and asked questions
#journalism #eastbourne
Southern Water faces fury over smells, sewage and plastic bead pollution
* Dozens attend Southern Water drop-in event demanding answers to odour and releases of sewage and plastic beads from its Eastbourne wastewater treatment works
* The company’s head of wastewater tell...
www.eastbournereporter.co.uk
November 17, 2025 at 7:40 AM
Great report on a huge problem for #Eastbourne: a dysfunctional & chronically underinvested wastewater treatment works. The recent massive spill of millions of toxic bio-beads from the plant is the worst single pollution incident so far, seriously contaminating local waters, beaches, & wildlife.
Battin down the hatches.
IMHO this won’t help federal Liberal Ley’s leadership either.
Such dysfunctional opposition isn’t good for democracy.
I wonder what Jeff Kennett , Steve Price etc will say?
Here we go round the mulberry bush. Again.
IMHO this won’t help federal Liberal Ley’s leadership either.
Such dysfunctional opposition isn’t good for democracy.
I wonder what Jeff Kennett , Steve Price etc will say?
Here we go round the mulberry bush. Again.
November 17, 2025 at 7:33 AM
Battin down the hatches.
IMHO this won’t help federal Liberal Ley’s leadership either.
Such dysfunctional opposition isn’t good for democracy.
I wonder what Jeff Kennett , Steve Price etc will say?
Here we go round the mulberry bush. Again.
IMHO this won’t help federal Liberal Ley’s leadership either.
Such dysfunctional opposition isn’t good for democracy.
I wonder what Jeff Kennett , Steve Price etc will say?
Here we go round the mulberry bush. Again.
Capitalism thrives on exploitation and fuels it. If you think the system is dysfunctional and taking advantage of the most vulnerable, it isn't your imagination - it is designed that way. The poor are fed to the greedy. It isn't a bug, that is why both parties fight to protect the status quo.
November 17, 2025 at 7:19 AM
Capitalism thrives on exploitation and fuels it. If you think the system is dysfunctional and taking advantage of the most vulnerable, it isn't your imagination - it is designed that way. The poor are fed to the greedy. It isn't a bug, that is why both parties fight to protect the status quo.
Pet peeve: companies describing themselves as “a family”? What are you trying to say here? You’re dysfunctional and bad at talking to each other?
November 17, 2025 at 7:18 AM
Pet peeve: companies describing themselves as “a family”? What are you trying to say here? You’re dysfunctional and bad at talking to each other?
Wow, another sign of a dysfunctional party
November 17, 2025 at 7:02 AM
Wow, another sign of a dysfunctional party
THEN that leaves Mike Johnson next..... as the stupid dysfunctional 'Speaker' of the House
November 17, 2025 at 6:31 AM
THEN that leaves Mike Johnson next..... as the stupid dysfunctional 'Speaker' of the House
One question. Why would any sane person vote for an insane person unless their system was totally dysfunctional.
November 17, 2025 at 6:24 AM
One question. Why would any sane person vote for an insane person unless their system was totally dysfunctional.
No one is saying one thing that is so obvious. The US "justice system" is horribly dysfunctional. Maybe it's always been like this. But you can't call this is civilized country when it takes > TWO DECADES for US law enforcement to deal with this.
November 17, 2025 at 6:03 AM
No one is saying one thing that is so obvious. The US "justice system" is horribly dysfunctional. Maybe it's always been like this. But you can't call this is civilized country when it takes > TWO DECADES for US law enforcement to deal with this.
These are from the exodus🚶♂️, when I had finally had enough of my toxic dysfunctional step family. After months of harassment, gaslighting, extortion, smear campaigns and abuse, I called it quits. I posted these signs on my door for them to see that we all have more than one side, narcy hypocrites.
November 17, 2025 at 5:56 AM
These are from the exodus🚶♂️, when I had finally had enough of my toxic dysfunctional step family. After months of harassment, gaslighting, extortion, smear campaigns and abuse, I called it quits. I posted these signs on my door for them to see that we all have more than one side, narcy hypocrites.
So?
Increasing the net worth of the bottom is the goal.
Increasing the net worth of the top is dysfunctional and will lead to the collapse of democracy.
Increasing the net worth of the bottom is the goal.
Increasing the net worth of the top is dysfunctional and will lead to the collapse of democracy.
November 17, 2025 at 5:32 AM
So?
Increasing the net worth of the bottom is the goal.
Increasing the net worth of the top is dysfunctional and will lead to the collapse of democracy.
Increasing the net worth of the bottom is the goal.
Increasing the net worth of the top is dysfunctional and will lead to the collapse of democracy.
1. Masterfully directed, surreal tales of chaos & damnation.
2. surreal & chaotic jump-scares & damned idiots who won’t put their cameras down.
3. Masterfully directed, human tales of chaos & dysfunction.
4. chaotic humans saying funny shit in dysfunctional set-ups
5.
2. surreal & chaotic jump-scares & damned idiots who won’t put their cameras down.
3. Masterfully directed, human tales of chaos & dysfunction.
4. chaotic humans saying funny shit in dysfunctional set-ups
5.
November 17, 2025 at 5:11 AM
1. Masterfully directed, surreal tales of chaos & damnation.
2. surreal & chaotic jump-scares & damned idiots who won’t put their cameras down.
3. Masterfully directed, human tales of chaos & dysfunction.
4. chaotic humans saying funny shit in dysfunctional set-ups
5.
2. surreal & chaotic jump-scares & damned idiots who won’t put their cameras down.
3. Masterfully directed, human tales of chaos & dysfunction.
4. chaotic humans saying funny shit in dysfunctional set-ups
5.
Ooh look 😳, socialism for dysfunctional corporations
November 17, 2025 at 5:05 AM
Ooh look 😳, socialism for dysfunctional corporations
philly/detroit nfl game is one of the stupidest/worst games i've ever seen. i am so mad at detroit's utter ineptitude throughout and i really hate this philly team in so many ways at this point. they're like this weird dysfunctional mess who keeps winning mostly on talent.
November 17, 2025 at 4:30 AM
philly/detroit nfl game is one of the stupidest/worst games i've ever seen. i am so mad at detroit's utter ineptitude throughout and i really hate this philly team in so many ways at this point. they're like this weird dysfunctional mess who keeps winning mostly on talent.
I'm adding a 6th: Dysfunctional family dynamics at family event
November 17, 2025 at 4:14 AM
I'm adding a 6th: Dysfunctional family dynamics at family event
What are your top 5 movie genres?
Here’s mine:
Christ, that’s horrible! And…bloody—why am I laughing?
Christ, they’re clueless! And…relatable—why am I laughing?
Quirky & dysfunctional. That’s America.
Why do I have to save everyone? I’m not a hero!
I may not look it, but I will survive.
Here’s mine:
Christ, that’s horrible! And…bloody—why am I laughing?
Christ, they’re clueless! And…relatable—why am I laughing?
Quirky & dysfunctional. That’s America.
Why do I have to save everyone? I’m not a hero!
I may not look it, but I will survive.
What are your top 5 movie genres?
Mine are:
- “OMG, I have *powers*?”
- dinosaurs
- animated plucky misfits with animal companions
- wait, it’s a musical
- blood soaked horror
Mine are:
- “OMG, I have *powers*?”
- dinosaurs
- animated plucky misfits with animal companions
- wait, it’s a musical
- blood soaked horror
What are your top 5 movie genres? mine are:
- when the sensitive guy finally figures out that there’s nothing wrong with him
- women kicking ass and taking names
- hard working folks who are also poets talking in verse while they get shit done
- dragons and magicks and pointy ears
- car chases
- when the sensitive guy finally figures out that there’s nothing wrong with him
- women kicking ass and taking names
- hard working folks who are also poets talking in verse while they get shit done
- dragons and magicks and pointy ears
- car chases
November 17, 2025 at 4:05 AM
What are your top 5 movie genres?
Here’s mine:
Christ, that’s horrible! And…bloody—why am I laughing?
Christ, they’re clueless! And…relatable—why am I laughing?
Quirky & dysfunctional. That’s America.
Why do I have to save everyone? I’m not a hero!
I may not look it, but I will survive.
Here’s mine:
Christ, that’s horrible! And…bloody—why am I laughing?
Christ, they’re clueless! And…relatable—why am I laughing?
Quirky & dysfunctional. That’s America.
Why do I have to save everyone? I’m not a hero!
I may not look it, but I will survive.
world's most dysfunctional workplace relationship award goes to whatever the fuck these two have going on
November 17, 2025 at 3:45 AM
world's most dysfunctional workplace relationship award goes to whatever the fuck these two have going on
theyre so fucking dysfunctional (again.) all of this because their resident gremlin witnessed The Horrors of border control and decided to just plunge her lance into a giant glass wall in front of security 😭
November 17, 2025 at 3:29 AM
theyre so fucking dysfunctional (again.) all of this because their resident gremlin witnessed The Horrors of border control and decided to just plunge her lance into a giant glass wall in front of security 😭
Wait, your condo has a quarterly magazine! I just joined my really dysfunctional HOA board and I’m working with some people to get a greater sense of community. What a great idea, maybe I’ll put this out as a community building activity
November 17, 2025 at 3:05 AM
Wait, your condo has a quarterly magazine! I just joined my really dysfunctional HOA board and I’m working with some people to get a greater sense of community. What a great idea, maybe I’ll put this out as a community building activity
Then war, war, war or worse becomes the only way out because we are so dysfunctional that we can no longer find our own way out, such is level of corruption in the West. In fact, some would prefer that you do not find your way out.
November 17, 2025 at 2:57 AM
Then war, war, war or worse becomes the only way out because we are so dysfunctional that we can no longer find our own way out, such is level of corruption in the West. In fact, some would prefer that you do not find your way out.
What an UGLY personality and choice of clothing.
How can any grandfather not be appalled on behalf of his wife, daughters, granddaughters, etc.
He's probably into pedophilia, beastiality, and every other dysfunctional sexual behaviour possible!
How can any grandfather not be appalled on behalf of his wife, daughters, granddaughters, etc.
He's probably into pedophilia, beastiality, and every other dysfunctional sexual behaviour possible!
November 17, 2025 at 2:47 AM
What an UGLY personality and choice of clothing.
How can any grandfather not be appalled on behalf of his wife, daughters, granddaughters, etc.
He's probably into pedophilia, beastiality, and every other dysfunctional sexual behaviour possible!
How can any grandfather not be appalled on behalf of his wife, daughters, granddaughters, etc.
He's probably into pedophilia, beastiality, and every other dysfunctional sexual behaviour possible!