Mitochondriale Dysfunktion bei Alterung, HIV und Long COVID: Mechanismen und therapeutische Möglichkeiten
„Mitochondriale Dysfunktion wird zunehmend als gemeinsamer Faktor für Alterung, HIV und Long COVID erkannt. Gemeinsame Mechanismen – darunter oxidativer Stress, …
„Mitochondriale Dysfunktion wird zunehmend als gemeinsamer Faktor für Alterung, HIV und Long COVID erkannt. Gemeinsame Mechanismen – darunter oxidativer Stress, …
November 2, 2025 at 1:48 PM
Mitochondriale Dysfunktion bei Alterung, HIV und Long COVID: Mechanismen und therapeutische Möglichkeiten
„Mitochondriale Dysfunktion wird zunehmend als gemeinsamer Faktor für Alterung, HIV und Long COVID erkannt. Gemeinsame Mechanismen – darunter oxidativer Stress, …
„Mitochondriale Dysfunktion wird zunehmend als gemeinsamer Faktor für Alterung, HIV und Long COVID erkannt. Gemeinsame Mechanismen – darunter oxidativer Stress, …
#MitochondrialDynamics are important regulators of various cancer cell phenotypes. This Essay explores the role of mitochondrial dynamic regulators in #tumor growth & #metastasis, discussing how they can be targeted to develop novel intervention strategies @plosbiology.org 🧪 plos.io/4o4KtOo
October 23, 2025 at 7:53 AM
#MitochondrialDynamics are important regulators of various cancer cell phenotypes. This Essay explores the role of mitochondrial dynamic regulators in #tumor growth & #metastasis, discussing how they can be targeted to develop novel intervention strategies @plosbiology.org 🧪 plos.io/4o4KtOo
www.sciencedirect.com/science/arti...
"- mtROS induces ZBP1 activity via sulfenylation at Cys327 independently of Zα domain.
- FDA-approved drug SQV targeting to Drp1 alleviates colitis in mice."
"- mtROS induces ZBP1 activity via sulfenylation at Cys327 independently of Zα domain.
- FDA-approved drug SQV targeting to Drp1 alleviates colitis in mice."
Epithelial mitochondrial fission-mediated PANoptosis is crucial for ulcerative colitis and its inhibition by saquinavir through Drp1
Ulcerative colitis (UC) is characterized by increased cell death in intestinal epithelial cell (IEC), which compromises gut barrier function and activ…
www.sciencedirect.com
March 10, 2025 at 8:34 PM
www.sciencedirect.com/science/arti...
"- mtROS induces ZBP1 activity via sulfenylation at Cys327 independently of Zα domain.
- FDA-approved drug SQV targeting to Drp1 alleviates colitis in mice."
"- mtROS induces ZBP1 activity via sulfenylation at Cys327 independently of Zα domain.
- FDA-approved drug SQV targeting to Drp1 alleviates colitis in mice."
DRP1/DMNL-1-mediated mitochondrial fission augments Rickettsia parkeri replication in macrophages https://www.biorxiv.org/content/10.1101/2025.06.25.661470v1
June 26, 2025 at 3:17 AM
DRP1/DMNL-1-mediated mitochondrial fission augments Rickettsia parkeri replication in macrophages https://www.biorxiv.org/content/10.1101/2025.06.25.661470v1
Removing Drp1 in mouse zygotes disrupts mitochondrial distribution, spindle formation & embryo development, revealing how vital this protein is for early life.
buff.ly/9GxSdBM
buff.ly/9GxSdBM
August 25, 2025 at 8:02 PM
Removing Drp1 in mouse zygotes disrupts mitochondrial distribution, spindle formation & embryo development, revealing how vital this protein is for early life.
buff.ly/9GxSdBM
buff.ly/9GxSdBM
The most feminist moment of the Mission Impossible series , and I will never forgive them for what they did in DRP1
December 14, 2023 at 2:44 AM
The most feminist moment of the Mission Impossible series , and I will never forgive them for what they did in DRP1
DRP1 induces neuroinflammation via transcriptional regulation of NF-ĸB https://www.biorxiv.org/content/10.1101/2025.09.02.673863v1
September 6, 2025 at 4:15 PM
DRP1 induces neuroinflammation via transcriptional regulation of NF-ĸB https://www.biorxiv.org/content/10.1101/2025.09.02.673863v1
Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation https://www.biorxiv.org/content/10.1101/2025.04.03.647131v1
April 4, 2025 at 11:30 AM
Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation https://www.biorxiv.org/content/10.1101/2025.04.03.647131v1
Inhibition of Mitochondrial Fission Protein Drp1 Ameliorates Myopathy in the D2-mdx Model of Duchenne Muscular Dystrophy https://www.biorxiv.org/content/10.1101/2024.12.26.628172v1
December 27, 2024 at 7:18 AM
Inhibition of Mitochondrial Fission Protein Drp1 Ameliorates Myopathy in the D2-mdx Model of Duchenne Muscular Dystrophy https://www.biorxiv.org/content/10.1101/2024.12.26.628172v1
www.ncbi.nlm.nih.gov/pmc/articles...
"Meanwhile, flubendazole increased dynamin-related protein ( #DRP1) expression, leading to the accumulation of PTEN induced putative kinase 1 ( #PINK1) and subsequent mitochondrial translocation of Parkin, thereby promoting excessive mitophagy."
"Meanwhile, flubendazole increased dynamin-related protein ( #DRP1) expression, leading to the accumulation of PTEN induced putative kinase 1 ( #PINK1) and subsequent mitochondrial translocation of Parkin, thereby promoting excessive mitophagy."
Flubendazole induces mitochondrial dysfunction and DRP1-mediated mitophagy by targeting EVA1A in breast cancer
Breast cancer is still one of the most common malignancies worldwide and remains a major clinical challenge. We previously reported that the anthelmintic drug flubendazole induced autophagy and apopto...
www.ncbi.nlm.nih.gov
January 13, 2025 at 5:25 PM
www.ncbi.nlm.nih.gov/pmc/articles...
"Meanwhile, flubendazole increased dynamin-related protein ( #DRP1) expression, leading to the accumulation of PTEN induced putative kinase 1 ( #PINK1) and subsequent mitochondrial translocation of Parkin, thereby promoting excessive mitophagy."
"Meanwhile, flubendazole increased dynamin-related protein ( #DRP1) expression, leading to the accumulation of PTEN induced putative kinase 1 ( #PINK1) and subsequent mitochondrial translocation of Parkin, thereby promoting excessive mitophagy."
🚀Ahead of print🚀
Effects of echinacoside on the regulation of mitochondrial fission induced by TBK1/Drp1 in rheumatoid arthritis
advances.umw.edu.pl/en/ahead-of-...
Effects of echinacoside on the regulation of mitochondrial fission induced by TBK1/Drp1 in rheumatoid arthritis
advances.umw.edu.pl/en/ahead-of-...
October 20, 2025 at 9:37 AM
🚀Ahead of print🚀
Effects of echinacoside on the regulation of mitochondrial fission induced by TBK1/Drp1 in rheumatoid arthritis
advances.umw.edu.pl/en/ahead-of-...
Effects of echinacoside on the regulation of mitochondrial fission induced by TBK1/Drp1 in rheumatoid arthritis
advances.umw.edu.pl/en/ahead-of-...
So I THINK this is my new Mission: Impossible ranking:
RN > GP > DRp1 > 3 > Fallout > 1 >>>>>>>>>> 2
RN > GP > DRp1 > 3 > Fallout > 1 >>>>>>>>>> 2
July 7, 2023 at 3:37 PM
So I THINK this is my new Mission: Impossible ranking:
RN > GP > DRp1 > 3 > Fallout > 1 >>>>>>>>>> 2
RN > GP > DRp1 > 3 > Fallout > 1 >>>>>>>>>> 2
I share your ire at DRP1. Mostly because I just don’t buy it. Two combatants of even approximately equal skill, one with a switchblade, the other with a sword. How the hell does the one with the sword lose? IT MAKES NO SENSE.
I still really like the movie, but that moment will always bother me.
I still really like the movie, but that moment will always bother me.
December 14, 2023 at 2:49 AM
I share your ire at DRP1. Mostly because I just don’t buy it. Two combatants of even approximately equal skill, one with a switchblade, the other with a sword. How the hell does the one with the sword lose? IT MAKES NO SENSE.
I still really like the movie, but that moment will always bother me.
I still really like the movie, but that moment will always bother me.
www.nature.com/articles/s42...
"Mechanistically, S100a8/a9 binding to RAGE induced Drp1 phosphorylation and mitochondrial fragmentation, resulting in muscle atrophy."
"Mechanistically, S100a8/a9 binding to RAGE induced Drp1 phosphorylation and mitochondrial fragmentation, resulting in muscle atrophy."
Elevated levels of S100A8 and S100A9 exacerbate muscle mitochondrial fragmentation in sepsis-induced muscle atrophy - Communications Biology
Sepsis-induced skeletal muscle atrophy is linked to increased mortality in septic patients; in this study, the authors identify the S100a8/a9-RAGE pathway as a key driver of mitochondrial fragmentatio...
www.nature.com
March 10, 2025 at 8:34 PM
www.nature.com/articles/s42...
"Mechanistically, S100a8/a9 binding to RAGE induced Drp1 phosphorylation and mitochondrial fragmentation, resulting in muscle atrophy."
"Mechanistically, S100a8/a9 binding to RAGE induced Drp1 phosphorylation and mitochondrial fragmentation, resulting in muscle atrophy."
Best first watches of July:
5. Barbie
4. Ponyo
3. Mission: Impossible - DRP1
2. Oppenheimer
1. Werckmeister Harmonies
5. Barbie
4. Ponyo
3. Mission: Impossible - DRP1
2. Oppenheimer
1. Werckmeister Harmonies
July 31, 2023 at 10:37 PM
Best first watches of July:
5. Barbie
4. Ponyo
3. Mission: Impossible - DRP1
2. Oppenheimer
1. Werckmeister Harmonies
5. Barbie
4. Ponyo
3. Mission: Impossible - DRP1
2. Oppenheimer
1. Werckmeister Harmonies
Hypoxia induces ferroptotic cell death mediated by activation of the inner mitochondrial membrane fission protein MTP18/Drp1 in invertebrates
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
February 18, 2025 at 1:08 PM
Hypoxia induces ferroptotic cell death mediated by activation of the inner mitochondrial membrane fission protein MTP18/Drp1 in invertebrates
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Kan noen fortelle meg *hvordan* Norge vil bli en "U-nasjon" av å avskaffe VAR?
Hva ved VAR er det som er så utviklende for fotballen?
www.vg.no/sport/i/dRp1...
Hva ved VAR er det som er så utviklende for fotballen?
www.vg.no/sport/i/dRp1...
Kjetil Rekdal om VAR: Mener ledere burde trukket seg
Aalesund-treneren kaster seg inn i VAR-debatten med å kritisere både supportermakten, Norges Fotballforbund og klubblederne.
www.vg.no
January 14, 2025 at 9:05 PM
Kan noen fortelle meg *hvordan* Norge vil bli en "U-nasjon" av å avskaffe VAR?
Hva ved VAR er det som er så utviklende for fotballen?
www.vg.no/sport/i/dRp1...
Hva ved VAR er det som er så utviklende for fotballen?
www.vg.no/sport/i/dRp1...
Patient mutations in DRP1 perturb synaptic maturation of cortical neurons https://www.biorxiv.org/content/10.1101/2024.08.23.609462v1
Patient mutations in DRP1 perturb synaptic maturation of cortical neurons https://www.biorxiv.org/content/10.1101/2024.08.23.609462v1
With the advent of exome sequencing, a growing number of children are being identified with de novo
www.biorxiv.org
August 25, 2024 at 8:30 AM
Patient mutations in DRP1 perturb synaptic maturation of cortical neurons https://www.biorxiv.org/content/10.1101/2024.08.23.609462v1
In @jcb.org, Rodriguez Salazar, @caglaeroglu.bsky.social et al. show that Drp1-mediated mitochondrial fission is necessary for peripheral #astrocyte process formation. Loss of Drp1 induces astrocyte reactivity & disrupts cortical astrocyte organization rupress.org/jcb/article/...
September 3, 2025 at 6:30 PM
In @jcb.org, Rodriguez Salazar, @caglaeroglu.bsky.social et al. show that Drp1-mediated mitochondrial fission is necessary for peripheral #astrocyte process formation. Loss of Drp1 induces astrocyte reactivity & disrupts cortical astrocyte organization rupress.org/jcb/article/...
Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin https://www.biorxiv.org/content/10.1101/2023.08.20.554022v1
August 21, 2023 at 3:46 AM
Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin https://www.biorxiv.org/content/10.1101/2023.08.20.554022v1
This tells us:
- Mitochondrial stress can be tracked from the blood
- These RNA markers (MFN1, MFN2, OPA1, DRP1, FIS1) are useful across multiple diseases
They’re linked not just to diagnosis, but also to how severe or advanced the condition is
- Mitochondrial stress can be tracked from the blood
- These RNA markers (MFN1, MFN2, OPA1, DRP1, FIS1) are useful across multiple diseases
They’re linked not just to diagnosis, but also to how severe or advanced the condition is
September 6, 2025 at 1:02 PM
This tells us:
- Mitochondrial stress can be tracked from the blood
- These RNA markers (MFN1, MFN2, OPA1, DRP1, FIS1) are useful across multiple diseases
They’re linked not just to diagnosis, but also to how severe or advanced the condition is
- Mitochondrial stress can be tracked from the blood
- These RNA markers (MFN1, MFN2, OPA1, DRP1, FIS1) are useful across multiple diseases
They’re linked not just to diagnosis, but also to how severe or advanced the condition is
DRP1/DMNL-1-mediated mitochondrial fission augments Rickettsia parkeri replication in macrophages https://www.biorxiv.org/content/10.1101/2025.06.25.661470v1
June 26, 2025 at 3:17 AM
DRP1/DMNL-1-mediated mitochondrial fission augments Rickettsia parkeri replication in macrophages https://www.biorxiv.org/content/10.1101/2025.06.25.661470v1
Var på #DRP1 her til morgen 😴 og snakke om den nye GPT5-model fra OpenAI. Heldigvis spurgte de mig ikke hvordan en flyvinge virker, for det er hverken jeg eller GPT5 helt skarpe på... Men små skridt kan også noget.
August 8, 2025 at 6:05 AM
Var på #DRP1 her til morgen 😴 og snakke om den nye GPT5-model fra OpenAI. Heldigvis spurgte de mig ikke hvordan en flyvinge virker, for det er hverken jeg eller GPT5 helt skarpe på... Men små skridt kan også noget.
This tells us:
- Mitochondrial stress can be tracked from the blood
- These RNA markers (MFN1, MFN2, OPA1, DRP1, FIS1) are useful across multiple diseases
- They’re linked not just to diagnosis, but also to how severe or advanced the condition is
- Mitochondrial stress can be tracked from the blood
- These RNA markers (MFN1, MFN2, OPA1, DRP1, FIS1) are useful across multiple diseases
- They’re linked not just to diagnosis, but also to how severe or advanced the condition is
August 31, 2025 at 1:03 PM
This tells us:
- Mitochondrial stress can be tracked from the blood
- These RNA markers (MFN1, MFN2, OPA1, DRP1, FIS1) are useful across multiple diseases
- They’re linked not just to diagnosis, but also to how severe or advanced the condition is
- Mitochondrial stress can be tracked from the blood
- These RNA markers (MFN1, MFN2, OPA1, DRP1, FIS1) are useful across multiple diseases
- They’re linked not just to diagnosis, but also to how severe or advanced the condition is