🚨 Webinar Alert! - Revolutionizing Structural Biology
On Oct 1 Dr. Nick Ariotti (U. Queensland) will share how his team imaged microtubules in lysate at 7.1 Å with a cryoTEM and NO traditional purification steps.
Register here: ter.li/66bytl
#structuralbiology #proteinmicroscopy #cryoEM #cryoET
On Oct 1 Dr. Nick Ariotti (U. Queensland) will share how his team imaged microtubules in lysate at 7.1 Å with a cryoTEM and NO traditional purification steps.
Register here: ter.li/66bytl
#structuralbiology #proteinmicroscopy #cryoEM #cryoET
September 25, 2025 at 5:26 PM
🚨 Webinar Alert! - Revolutionizing Structural Biology
On Oct 1 Dr. Nick Ariotti (U. Queensland) will share how his team imaged microtubules in lysate at 7.1 Å with a cryoTEM and NO traditional purification steps.
Register here: ter.li/66bytl
#structuralbiology #proteinmicroscopy #cryoEM #cryoET
On Oct 1 Dr. Nick Ariotti (U. Queensland) will share how his team imaged microtubules in lysate at 7.1 Å with a cryoTEM and NO traditional purification steps.
Register here: ter.li/66bytl
#structuralbiology #proteinmicroscopy #cryoEM #cryoET
#cryoTEM folk - v basic question - how are you storing your grid boxes and lids? Grids levitating out of holes with static. I hear wash them with ethanol, and no plastics. Any other tips? Anyone still on here? #loneranger
November 21, 2024 at 5:18 PM
#cryoTEM folk - v basic question - how are you storing your grid boxes and lids? Grids levitating out of holes with static. I hear wash them with ethanol, and no plastics. Any other tips? Anyone still on here? #loneranger
Have you signed up yet? In just 1 week, Dr. Mandy Janssen will be giving a webinar + Q&A diving into the applications of #cryoTEM for #LNP development!
Don't miss out on this deep dive: nimgs.zoom.us/webinar/regi...
Can't make it live? Sign up to get a recording, or send in your questions!
Don't miss out on this deep dive: nimgs.zoom.us/webinar/regi...
Can't make it live? Sign up to get a recording, or send in your questions!
June 5, 2025 at 2:46 PM
Have you signed up yet? In just 1 week, Dr. Mandy Janssen will be giving a webinar + Q&A diving into the applications of #cryoTEM for #LNP development!
Don't miss out on this deep dive: nimgs.zoom.us/webinar/regi...
Can't make it live? Sign up to get a recording, or send in your questions!
Don't miss out on this deep dive: nimgs.zoom.us/webinar/regi...
Can't make it live? Sign up to get a recording, or send in your questions!
I'll collect all my cryoTEM data at centers, and mostly PNCC - hopefully lots of opportunity for collaboration!
January 24, 2024 at 3:27 PM
I'll collect all my cryoTEM data at centers, and mostly PNCC - hopefully lots of opportunity for collaboration!
🗣️ "Hey FBI, explain how it works!"
Today, we’re exploring one of #electronmicroscopy sub-techniques: Cryo-TEM.
💡 Did you know? #CryoTEM is available on many platforms across France-BioImaging infrastructure.
Watch the video to learn more and find out where you can access it!
Today, we’re exploring one of #electronmicroscopy sub-techniques: Cryo-TEM.
💡 Did you know? #CryoTEM is available on many platforms across France-BioImaging infrastructure.
Watch the video to learn more and find out where you can access it!
September 25, 2025 at 2:24 PM
🗣️ "Hey FBI, explain how it works!"
Today, we’re exploring one of #electronmicroscopy sub-techniques: Cryo-TEM.
💡 Did you know? #CryoTEM is available on many platforms across France-BioImaging infrastructure.
Watch the video to learn more and find out where you can access it!
Today, we’re exploring one of #electronmicroscopy sub-techniques: Cryo-TEM.
💡 Did you know? #CryoTEM is available on many platforms across France-BioImaging infrastructure.
Watch the video to learn more and find out where you can access it!
Celebrating 50 years - 2016-2025 James Whisstock EM! Synthetic Biology. Protein folding. Native MS. Richard Henderson. Chris Overall at every meeting. Eleanor Dodson, Frances Arnold, Tamir Gonen, Nemad Ban. Tom Steitz. 2020 a lot of CryoTEM. 2021 Hybrid!.. Alphafold 😟😵💫🫣😍. A plan...
February 11, 2025 at 10:05 AM
Celebrating 50 years - 2016-2025 James Whisstock EM! Synthetic Biology. Protein folding. Native MS. Richard Henderson. Chris Overall at every meeting. Eleanor Dodson, Frances Arnold, Tamir Gonen, Nemad Ban. Tom Steitz. 2020 a lot of CryoTEM. 2021 Hybrid!.. Alphafold 😟😵💫🫣😍. A plan...
Do you know how #LNPs show up in #cryoTEM versus negative stain TEM?
Want to learn more about the advantages of cryo-TEM for LNPs and other #liposomal samples? Tune in for the full webinar from Dr. Maria (Mandy) Janssen:
Want to learn more about the advantages of cryo-TEM for LNPs and other #liposomal samples? Tune in for the full webinar from Dr. Maria (Mandy) Janssen:
Enhance LNP Development: Cryo-TEM & Automated Image Analysis Tools
Join Dr. Mandy Janssen, Scientific Director of Characterization at NIS, to:- Discover how cryo-TEM enables high-resolution visualization of individual LNPs i...
youtu.be
July 15, 2025 at 5:03 PM
Do you know how #LNPs show up in #cryoTEM versus negative stain TEM?
Want to learn more about the advantages of cryo-TEM for LNPs and other #liposomal samples? Tune in for the full webinar from Dr. Maria (Mandy) Janssen:
Want to learn more about the advantages of cryo-TEM for LNPs and other #liposomal samples? Tune in for the full webinar from Dr. Maria (Mandy) Janssen:
🔬 Working on #viral, #lipid, or #inorganic formulations? Cryo-TEM imaging & quantitative analysis can reveal their contents. Phase appropriate #cryoTEM characterization helps at any pipeline stage, and reveal answers about #stability, #morphology & more.
📩 Email nischr@nanoimagingservices.com
📩 Email nischr@nanoimagingservices.com
December 10, 2024 at 6:00 PM
🔬 Working on #viral, #lipid, or #inorganic formulations? Cryo-TEM imaging & quantitative analysis can reveal their contents. Phase appropriate #cryoTEM characterization helps at any pipeline stage, and reveal answers about #stability, #morphology & more.
📩 Email nischr@nanoimagingservices.com
📩 Email nischr@nanoimagingservices.com
❄️ #InsideUNLBiotech: CRYOEM
Our 200 kV Cryo-electron microscope images frozen samples at atomic resolution, magnifying at 70,000×+. It reveals protein structures, drug targets & more, advancing discoveries in life & disease.
🔗http://go.unl.edu/cryo
Our 200 kV Cryo-electron microscope images frozen samples at atomic resolution, magnifying at 70,000×+. It reveals protein structures, drug targets & more, advancing discoveries in life & disease.
🔗http://go.unl.edu/cryo
August 20, 2025 at 2:21 PM
❄️ #InsideUNLBiotech: CRYOEM
Our 200 kV Cryo-electron microscope images frozen samples at atomic resolution, magnifying at 70,000×+. It reveals protein structures, drug targets & more, advancing discoveries in life & disease.
🔗http://go.unl.edu/cryo
Our 200 kV Cryo-electron microscope images frozen samples at atomic resolution, magnifying at 70,000×+. It reveals protein structures, drug targets & more, advancing discoveries in life & disease.
🔗http://go.unl.edu/cryo
Discover #cryoTEM images of your lipid nanoparticles, drug-loaded liposomes, & micelles. Gain critical insights into morphology, blebbing, payload, & more.
Email us at nischr@nanoimagingservices.com to learn more.
Email us at nischr@nanoimagingservices.com to learn more.
February 18, 2025 at 6:58 PM
Discover #cryoTEM images of your lipid nanoparticles, drug-loaded liposomes, & micelles. Gain critical insights into morphology, blebbing, payload, & more.
Email us at nischr@nanoimagingservices.com to learn more.
Email us at nischr@nanoimagingservices.com to learn more.
And from last week, paper from Life Sciences at Nottingham on a key step in developing renewable carbon use through biofermentation (with cryoTEM from @uonnmrc.bsky.social )
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Collapse of Lipid Membranes into Distended Lipidic Cubic Phases at High Solvent Levels, Membrane Remodelling, and Self-Repair
Performance plastics, such as poly(methyl methacrylate), underpin the modern economy. Global manufacturing of plastic precursors relies on fossil carbon sources, and the urgently needed shift toward r...
pubs.acs.org
July 8, 2025 at 10:12 AM
And from last week, paper from Life Sciences at Nottingham on a key step in developing renewable carbon use through biofermentation (with cryoTEM from @uonnmrc.bsky.social )
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Stefan Bröer on developing amino acid transporters the right way 😄 Targeting specific transporters with nM affinity and characterisation with cryoTEM. Docking limited help! Real binding site defines an allosteric inhibitor mechanism👍 #ASBMB2023
November 21, 2024 at 4:30 PM
Stefan Bröer on developing amino acid transporters the right way 😄 Targeting specific transporters with nM affinity and characterisation with cryoTEM. Docking limited help! Real binding site defines an allosteric inhibitor mechanism👍 #ASBMB2023
Unexpected results in your #LNP formulations? Join our webinar + Q&A to learn how #cryoTEM imaging can help provide answers.
We will reveal how cryo-TEM can provide reliable, reproducible data (size, morphology, lamellarity, blebs) in one dataset.
Sign up: nimgs.zoom.us/webinar/regi...
We will reveal how cryo-TEM can provide reliable, reproducible data (size, morphology, lamellarity, blebs) in one dataset.
Sign up: nimgs.zoom.us/webinar/regi...
June 10, 2025 at 3:55 PM
Unexpected results in your #LNP formulations? Join our webinar + Q&A to learn how #cryoTEM imaging can help provide answers.
We will reveal how cryo-TEM can provide reliable, reproducible data (size, morphology, lamellarity, blebs) in one dataset.
Sign up: nimgs.zoom.us/webinar/regi...
We will reveal how cryo-TEM can provide reliable, reproducible data (size, morphology, lamellarity, blebs) in one dataset.
Sign up: nimgs.zoom.us/webinar/regi...
When it comes to #lentivirus characterization, seeing is believing. Traditional analytical methods tell you what's there, but #cryoTEM shows you exactly how it's organized.
Learn more: www.nanoimagingservices.com/nanoparticle...
Learn more: www.nanoimagingservices.com/nanoparticle...
August 6, 2025 at 4:50 PM
When it comes to #lentivirus characterization, seeing is believing. Traditional analytical methods tell you what's there, but #cryoTEM shows you exactly how it's organized.
Learn more: www.nanoimagingservices.com/nanoparticle...
Learn more: www.nanoimagingservices.com/nanoparticle...
At #EMBOinsitu and looking for a motivated postdoc joining an interdisciplinary project in my lab:
jobs.icr.ac.uk/vacancies/11...
the-alfieri-lab.co.uk
#cryoem #cryotem
jobs.icr.ac.uk/vacancies/11...
the-alfieri-lab.co.uk
#cryoem #cryotem
Postdoctoral Training Fellow in Chelsea | The Institute of Cancer Research
View details and apply for this Postdoctoral Training Fellow vacancy in Chelsea .
Salary: Dependent on relevant Postdoctoral experience. Future progression is based on annual performan...
jobs.icr.ac.uk
February 5, 2025 at 10:05 PM
At #EMBOinsitu and looking for a motivated postdoc joining an interdisciplinary project in my lab:
jobs.icr.ac.uk/vacancies/11...
the-alfieri-lab.co.uk
#cryoem #cryotem
jobs.icr.ac.uk/vacancies/11...
the-alfieri-lab.co.uk
#cryoem #cryotem
While the focus will be on routine TEM operation, the program also includes:
❄️A demonstration of the cryoTEM workflow
🧪A brief overview of sample preparation methods
❄️A demonstration of the cryoTEM workflow
🧪A brief overview of sample preparation methods
October 17, 2025 at 6:44 AM
While the focus will be on routine TEM operation, the program also includes:
❄️A demonstration of the cryoTEM workflow
🧪A brief overview of sample preparation methods
❄️A demonstration of the cryoTEM workflow
🧪A brief overview of sample preparation methods
🧪 Conflicting results from DLS? #CryoTEM imaging can provide quantitative and qualitative data for smaller particles, like iron nanoparticle formulations, all in one study. Reach out to nischr@nanoimagingservices.com to learn how cryo-TEM imaging can help you meet milestones faster.
September 24, 2025 at 5:08 PM
🧪 Conflicting results from DLS? #CryoTEM imaging can provide quantitative and qualitative data for smaller particles, like iron nanoparticle formulations, all in one study. Reach out to nischr@nanoimagingservices.com to learn how cryo-TEM imaging can help you meet milestones faster.
Xin Jiang up next - Plasmodium: pentameric coupled proton/lactate transporter. 🦟 expression, membrane-bound cryoTEM 🤩 Gating mechanism elucidated by inhibitor bound structure. Proton coupling - lactate charge neutralisation? #ASMBM2023
November 21, 2024 at 4:23 PM
Xin Jiang up next - Plasmodium: pentameric coupled proton/lactate transporter. 🦟 expression, membrane-bound cryoTEM 🤩 Gating mechanism elucidated by inhibitor bound structure. Proton coupling - lactate charge neutralisation? #ASMBM2023
Poor contrast TEM images got you feeling grey? No problem!
Our latest tutorial will help you quickly & easily enhance the contrast and add scale bars to your #cryoTEM or negative stain TEM images so they’re ready for publication:
www.nanoimagingservices.com/about/blog/e...
Our latest tutorial will help you quickly & easily enhance the contrast and add scale bars to your #cryoTEM or negative stain TEM images so they’re ready for publication:
www.nanoimagingservices.com/about/blog/e...
June 25, 2025 at 6:03 PM
Poor contrast TEM images got you feeling grey? No problem!
Our latest tutorial will help you quickly & easily enhance the contrast and add scale bars to your #cryoTEM or negative stain TEM images so they’re ready for publication:
www.nanoimagingservices.com/about/blog/e...
Our latest tutorial will help you quickly & easily enhance the contrast and add scale bars to your #cryoTEM or negative stain TEM images so they’re ready for publication:
www.nanoimagingservices.com/about/blog/e...
@renaemryan1 Glutamate/Cl transporter. Crosslinking, cryoTEM, and a cool Arg/His swap with pH dependent switch from Cl to Na? transport (!) at the pinch point 🤏. Amazing 👏 #ASBMB2023
November 21, 2024 at 4:30 PM
@renaemryan1 Glutamate/Cl transporter. Crosslinking, cryoTEM, and a cool Arg/His swap with pH dependent switch from Cl to Na? transport (!) at the pinch point 🤏. Amazing 👏 #ASBMB2023
La Dra. Delgado presenta la Unitat de Microscòpia Electrònica i Tècniques afins.
#TEM, #SEM, #CryoTEM #CryoFIBSEM i #SBFSEM són algunes de les tècniques a disposició dels investigadors als #CCiTUB que els hi permetrà integrar la informació extreta mitjançant diferents tipus de microscòpies.
#TEM, #SEM, #CryoTEM #CryoFIBSEM i #SBFSEM són algunes de les tècniques a disposició dels investigadors als #CCiTUB que els hi permetrà integrar la informació extreta mitjançant diferents tipus de microscòpies.
September 17, 2025 at 12:06 PM
Light-ning talks #LorneProteins2025 Mengqi Pan on TIR domain signalling scaffold of Toll-like receptor sensing. Adaptor proteins - 4 principal - 5beta/5helices fold. Self assemble into filaments. TRIF and TRAM filaments in vitro. 5.6 Å resolution cryoTEM. BE and BCD interface organise filament. 👏
February 11, 2025 at 1:33 AM
Light-ning talks #LorneProteins2025 Mengqi Pan on TIR domain signalling scaffold of Toll-like receptor sensing. Adaptor proteins - 4 principal - 5beta/5helices fold. Self assemble into filaments. TRIF and TRAM filaments in vitro. 5.6 Å resolution cryoTEM. BE and BCD interface organise filament. 👏
New paper led by the University of Nottingham’s School of Pharmacy, with the nmRC's OrbiSIMS revealing the surface structure of lipid nanoparticles (also including cryoTEM from the nmRC)
www.nature.com/articles/s42...
@uonnmrc.bsky.social
www.nature.com/articles/s42...
@uonnmrc.bsky.social
Study on molecular orientation and stratification in RNA-lipid nanoparticles by cryogenic orbitrap secondary ion mass spectrometry - Communications Chemistry
Lipid nanoparticles (LNPs) are used for RNA formulation to achieve the delivery of vaccines and other therapies, however, their transfection efficiency is often low. Existing analytical techniques are...
www.nature.com
May 22, 2025 at 11:09 AM
New paper led by the University of Nottingham’s School of Pharmacy, with the nmRC's OrbiSIMS revealing the surface structure of lipid nanoparticles (also including cryoTEM from the nmRC)
www.nature.com/articles/s42...
@uonnmrc.bsky.social
www.nature.com/articles/s42...
@uonnmrc.bsky.social
❓ What unique insights does #cryoTEM imaging reveal about hashtag#LNPs?
🔬 We show the effects of process changes on #lipidnanoparticle #morphology, particularly #bleb features, which cannot be easily observed or measured with other analytical methods.
👩🔬 See the results: https://bit.ly/lnp-wp
🔬 We show the effects of process changes on #lipidnanoparticle #morphology, particularly #bleb features, which cannot be easily observed or measured with other analytical methods.
👩🔬 See the results: https://bit.ly/lnp-wp
Cryo-TEM as an Analytical Tool for LNP Characterization
Cryo-TEM as an Analytical Tool for LNP Characterization shared by Chloe Wood
lnkd.in
December 17, 2024 at 6:00 PM
❓ What unique insights does #cryoTEM imaging reveal about hashtag#LNPs?
🔬 We show the effects of process changes on #lipidnanoparticle #morphology, particularly #bleb features, which cannot be easily observed or measured with other analytical methods.
👩🔬 See the results: https://bit.ly/lnp-wp
🔬 We show the effects of process changes on #lipidnanoparticle #morphology, particularly #bleb features, which cannot be easily observed or measured with other analytical methods.
👩🔬 See the results: https://bit.ly/lnp-wp
Live webinar! Learn about automated AAV empty/full capsid ratio analysis with cryo-TEM on Thursday May 15, 11am PST, 2pm EST.
Learn the advantages of cryoTEM for assessing AAV formulations & how AAV empty/full capsid status is determined.
Sign up: nimgs.zoom.us/webinar/regi...
Learn the advantages of cryoTEM for assessing AAV formulations & how AAV empty/full capsid status is determined.
Sign up: nimgs.zoom.us/webinar/regi...
Welcome! You are invited to join a webinar: Quantitative Empty/Full Analysis of AAV Capsids Using Cryo-TEM. After registering, you will receive a confirmation email about joining the webinar.
Join Dr. Eric Bushong, Principal Scientist, for a 30 minute webinar followed by live Q&A.
- The advantages of the cryo-TEM approach for assessing AAV formulations
- How AAV empty/full capsid status ...
nimgs.zoom.us
April 21, 2025 at 5:38 PM
Live webinar! Learn about automated AAV empty/full capsid ratio analysis with cryo-TEM on Thursday May 15, 11am PST, 2pm EST.
Learn the advantages of cryoTEM for assessing AAV formulations & how AAV empty/full capsid status is determined.
Sign up: nimgs.zoom.us/webinar/regi...
Learn the advantages of cryoTEM for assessing AAV formulations & how AAV empty/full capsid status is determined.
Sign up: nimgs.zoom.us/webinar/regi...