🚀 Yesterday, CeMM joined the #EULIFE Pitching Event 2025!
#CELLFIE, cell engineering for immunotherapy enhancement, by Christoph Bock, Eugenia Pankevich & Cosmas Arnold (@bocklab.bsky.social), represented CeMM among 8 innovative pitches from @eu-life.bsky.social institutes 👏
#CELLFIE, cell engineering for immunotherapy enhancement, by Christoph Bock, Eugenia Pankevich & Cosmas Arnold (@bocklab.bsky.social), represented CeMM among 8 innovative pitches from @eu-life.bsky.social institutes 👏
👉 The EU-LIFE Pitching Event 2025 brought together 8 projects from 8 institutes, pitching to 17 VCs & biotech innovators from across Europe.
The event offered the researchers a valuable opportunity to discuss ideas with investors and gain insights into the translational and entrepreneurial pathway.
The event offered the researchers a valuable opportunity to discuss ideas with investors and gain insights into the translational and entrepreneurial pathway.
November 13, 2025 at 12:56 PM
🚀 Yesterday, CeMM joined the #EULIFE Pitching Event 2025!
#CELLFIE, cell engineering for immunotherapy enhancement, by Christoph Bock, Eugenia Pankevich & Cosmas Arnold (@bocklab.bsky.social), represented CeMM among 8 innovative pitches from @eu-life.bsky.social institutes 👏
#CELLFIE, cell engineering for immunotherapy enhancement, by Christoph Bock, Eugenia Pankevich & Cosmas Arnold (@bocklab.bsky.social), represented CeMM among 8 innovative pitches from @eu-life.bsky.social institutes 👏
November 11, 2025 at 8:56 PM
Cellfie Mobile launches Travel eSIM: connectivity abroad in just four clicks
Free access to Google Maps, WhatsApp, and Messenger — even after your data runs out.
https://oc-media.org/cellfie-mobile-launches-travel-esim-connectivity-abroad-in-just-four-clicks/
Free access to Google Maps, WhatsApp, and Messenger — even after your data runs out.
https://oc-media.org/cellfie-mobile-launches-travel-esim-connectivity-abroad-in-just-four-clicks/
Cellfie Mobile launches Travel eSIM: connectivity abroad in just four clicks
Free access to Google Maps, WhatsApp, and Messenger — even after your data runs out.
oc-media.org
November 10, 2025 at 3:38 PM
Cellfie Mobile launches Travel eSIM: connectivity abroad in just four clicks
Free access to Google Maps, WhatsApp, and Messenger — even after your data runs out.
https://oc-media.org/cellfie-mobile-launches-travel-esim-connectivity-abroad-in-just-four-clicks/
Free access to Google Maps, WhatsApp, and Messenger — even after your data runs out.
https://oc-media.org/cellfie-mobile-launches-travel-esim-connectivity-abroad-in-just-four-clicks/
In October's newsletter, discover how scientists used stem cell technology and AI to uncover a gene that interferes with heart development in people with Down syndrome, learn how scientists have trained a microscope to conduct experiments by itself, and don’t miss this spooky cellfie.
Cell Signals│Scientists Pinpoint a Key Gene Behind Heart Defects in Down Syndrome
Discover how scientists used stem cell technology and AI to uncover a gene that interferes with heart development in babies with Down syndrome, learn how scientists have trained a microscope to conduct experiments by itself, and don't miss this spooky c...
mailchi.mp
October 30, 2025 at 4:05 PM
In October's newsletter, discover how scientists used stem cell technology and AI to uncover a gene that interferes with heart development in people with Down syndrome, learn how scientists have trained a microscope to conduct experiments by itself, and don’t miss this spooky cellfie.
We’re thrilled to launch the MPI Brain's @mpibrain.bsky.social new Cellfies series!
Neurons in the larval zebrafish brain react to motion left (purple) or right (green). Explore our Algorithms and Circuits research 🔗 brain.mpg.de/schuhknecht
#Cellfie #CalciumImaging #SystemsNeuroscience
Neurons in the larval zebrafish brain react to motion left (purple) or right (green). Explore our Algorithms and Circuits research 🔗 brain.mpg.de/schuhknecht
#Cellfie #CalciumImaging #SystemsNeuroscience
October 17, 2025 at 11:09 AM
We’re thrilled to launch the MPI Brain's @mpibrain.bsky.social new Cellfies series!
Neurons in the larval zebrafish brain react to motion left (purple) or right (green). Explore our Algorithms and Circuits research 🔗 brain.mpg.de/schuhknecht
#Cellfie #CalciumImaging #SystemsNeuroscience
Neurons in the larval zebrafish brain react to motion left (purple) or right (green). Explore our Algorithms and Circuits research 🔗 brain.mpg.de/schuhknecht
#Cellfie #CalciumImaging #SystemsNeuroscience
What a CELLFIE!!! 🤩
Testing photobooth with @agatawitkowska.bsky.social at #GSM2025 @cim-imprs-gsm.bsky.social Thanks to the organisers and speakers for a fantastic meeting!
October 9, 2025 at 5:21 PM
What a CELLFIE!!! 🤩
🔥Hot Off the Press | 🧬 Nature: CRISPR screen finds new ways to boost CAR T cells.
CELLFIE platform → RHOG & FAS knockouts supercharge proliferation, persistence & tumor control.
🔗Read more: www.nature.com/articles/s41...
#CARTcells #CRISPR #Immunotherapy #Nature
CELLFIE platform → RHOG & FAS knockouts supercharge proliferation, persistence & tumor control.
🔗Read more: www.nature.com/articles/s41...
#CARTcells #CRISPR #Immunotherapy #Nature
October 6, 2025 at 5:03 PM
🔥Hot Off the Press | 🧬 Nature: CRISPR screen finds new ways to boost CAR T cells.
CELLFIE platform → RHOG & FAS knockouts supercharge proliferation, persistence & tumor control.
🔗Read more: www.nature.com/articles/s41...
#CARTcells #CRISPR #Immunotherapy #Nature
CELLFIE platform → RHOG & FAS knockouts supercharge proliferation, persistence & tumor control.
🔗Read more: www.nature.com/articles/s41...
#CARTcells #CRISPR #Immunotherapy #Nature
Wiener Forschende haben die CAR-T-Therapie gegen Blutkrebs verbessert: Mit der Plattform CELLFIE schnitten sie per Genschere Gene aus Immunzellen und fanden Kombinationen, die die Abwehrkräfte stärker, langlebiger und treffsicherer machen. Das könnte die Behandlung grundlegend verändern […]
Original post on norden.social
norden.social
September 25, 2025 at 11:12 AM
Wiener Forschende haben die CAR-T-Therapie gegen Blutkrebs verbessert: Mit der Plattform CELLFIE schnitten sie per Genschere Gene aus Immunzellen und fanden Kombinationen, die die Abwehrkräfte stärker, langlebiger und treffsicherer machen. Das könnte die Behandlung grundlegend verändern […]
⚕️ Our CELLFIE platform supports clinical translation of CRISPR-boosted CAR T cells. For example, to avoid the DNA double-strand breaks introduced by CRISPR knockout, we performed a tiling base-editing screen across RHOG and identified promising gRNA for clinical testing. (11/13)
September 24, 2025 at 6:42 PM
⚕️ Our CELLFIE platform supports clinical translation of CRISPR-boosted CAR T cells. For example, to avoid the DNA double-strand breaks introduced by CRISPR knockout, we performed a tiling base-editing screen across RHOG and identified promising gRNA for clinical testing. (11/13)
🔥 What’s next? Our discovery of strong combined effects for RHOG & FAS knockout underlines the potential of synergistic gene edits for boosting CAR T cell function. We thus integrated combinatorial screening into CELLFIE, using the Blainey lab’s CROPseq-multi method. (10/13)
September 24, 2025 at 6:42 PM
🔥 What’s next? Our discovery of strong combined effects for RHOG & FAS knockout underlines the potential of synergistic gene edits for boosting CAR T cell function. We thus integrated combinatorial screening into CELLFIE, using the Blainey lab’s CROPseq-multi method. (10/13)
🩸 Using CELLFIE, we conducted 58 genome-wide CRISPR screens, with readouts for CAR T cell proliferation, target cell recognition, activation, apoptosis & fratricide, and exhaustion. The screens identified known genes (PD-1, CTLA4, TIM3, TIGIT etc.) and promising new hits. (3/13)
September 24, 2025 at 6:42 PM
🩸 Using CELLFIE, we conducted 58 genome-wide CRISPR screens, with readouts for CAR T cell proliferation, target cell recognition, activation, apoptosis & fratricide, and exhaustion. The screens identified known genes (PD-1, CTLA4, TIM3, TIGIT etc.) and promising new hits. (3/13)
⚙️ We developed CELLFIE (“cell engineering for immunotherapy enhancement”), a CRISPR platform to make & test gene-edited CAR T cells at scale. CELLFIE supports in vitro & in vivo screens with various clinically relevant readouts, plus combinatorial & base-editing screens. (2/13)
September 24, 2025 at 6:42 PM
⚙️ We developed CELLFIE (“cell engineering for immunotherapy enhancement”), a CRISPR platform to make & test gene-edited CAR T cells at scale. CELLFIE supports in vitro & in vivo screens with various clinically relevant readouts, plus combinatorial & base-editing screens. (2/13)
CELLFIE supports diverse CRISPR modalities. Base editing proved especially powerful. Tiling screens of RHOG suggest inhibition of GTP binding pocket as therapeutic angle and identified gRNAs for clinical translation. (7/7)
September 24, 2025 at 3:48 PM
CELLFIE supports diverse CRISPR modalities. Base editing proved especially powerful. Tiling screens of RHOG suggest inhibition of GTP binding pocket as therapeutic angle and identified gRNAs for clinical translation. (7/7)
With many promising single edits reported across labs, the key challenge is combining them into tailored therapeutic designs. We extended CELLFIE with combinatorial screens and discovered a strong synergy between RHOG and FAS knockouts. (6/7)
September 24, 2025 at 3:48 PM
With many promising single edits reported across labs, the key challenge is combining them into tailored therapeutic designs. We extended CELLFIE with combinatorial screens and discovered a strong synergy between RHOG and FAS knockouts. (6/7)
#CELLFIE for CAR T screening—a new mRNA-based platform for screening primary cells. CAR + gRNA library are delivered by lentivirus, CRISPR modifiers as electroporated mRNA. That’s more flexible and effective than existing T cell screening methods. (1/7)
September 24, 2025 at 3:48 PM
#CELLFIE for CAR T screening—a new mRNA-based platform for screening primary cells. CAR + gRNA library are delivered by lentivirus, CRISPR modifiers as electroporated mRNA. That’s more flexible and effective than existing T cell screening methods. (1/7)
CAR T cells showcase the enormous potential of cell therapies, but often fail due to lack of evolutionary optimization. Today in @nature.com , we use #CELLFIE to engineer cell therapies at scale and share the largest resource of CRISPR screens in CAR T cells. www.nature.com/articles/s41...
Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature
CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.
www.nature.com
September 24, 2025 at 3:44 PM
CAR T cells showcase the enormous potential of cell therapies, but often fail due to lack of evolutionary optimization. Today in @nature.com , we use #CELLFIE to engineer cell therapies at scale and share the largest resource of CRISPR screens in CAR T cells. www.nature.com/articles/s41...
🔬 Scientists at #CeMM & @meduniwien.ac.at developed #CELLFIE, a #CRISPR platform to boost CAR T cells, a @nature.com study shows.
They find that knocking out RHOG makes CAR T cells fitter & more effective vs leukemia in mice.
➡️ Read more: bit.ly/4gFeCRs
➡️ The study: go.nature.com/4mkPy39
They find that knocking out RHOG makes CAR T cells fitter & more effective vs leukemia in mice.
➡️ Read more: bit.ly/4gFeCRs
➡️ The study: go.nature.com/4mkPy39
September 24, 2025 at 3:05 PM
🔬 Scientists at #CeMM & @meduniwien.ac.at developed #CELLFIE, a #CRISPR platform to boost CAR T cells, a @nature.com study shows.
They find that knocking out RHOG makes CAR T cells fitter & more effective vs leukemia in mice.
➡️ Read more: bit.ly/4gFeCRs
➡️ The study: go.nature.com/4mkPy39
They find that knocking out RHOG makes CAR T cells fitter & more effective vs leukemia in mice.
➡️ Read more: bit.ly/4gFeCRs
➡️ The study: go.nature.com/4mkPy39
I see you took a cellfie.
September 19, 2025 at 6:43 PM
I see you took a cellfie.
“Cellfie: A triple-stained portrait of HeLa’s senescence” by Spoorthi Suresh Hiremath (@imgprague.bsky.social; @gregorlab.bsky.social) has won the Prague @eurobioimaging.bsky.social Node Picture of the Month. Congrats Spoorthi!
August 20, 2025 at 4:02 PM
“Cellfie: A triple-stained portrait of HeLa’s senescence” by Spoorthi Suresh Hiremath (@imgprague.bsky.social; @gregorlab.bsky.social) has won the Prague @eurobioimaging.bsky.social Node Picture of the Month. Congrats Spoorthi!
Cellfie! (My own blood cells)
August 18, 2025 at 11:41 AM
Cellfie! (My own blood cells)
💥 Paper accepted (in principle) #cellfie 🤩
A long wait, a beautiful project, some amazing collaborations.
Stay tuned for more !
ALT : how cells (and cell-like beads) are deformed in constraining vessels
A long wait, a beautiful project, some amazing collaborations.
Stay tuned for more !
ALT : how cells (and cell-like beads) are deformed in constraining vessels
July 25, 2025 at 7:01 AM
💥 Paper accepted (in principle) #cellfie 🤩
A long wait, a beautiful project, some amazing collaborations.
Stay tuned for more !
ALT : how cells (and cell-like beads) are deformed in constraining vessels
A long wait, a beautiful project, some amazing collaborations.
Stay tuned for more !
ALT : how cells (and cell-like beads) are deformed in constraining vessels
I guess we can call this Cellfie 😂
July 9, 2025 at 6:26 AM
I guess we can call this Cellfie 😂
Cellfie Project: Young IWK patients with leukemia get to see disease at cellular level globalnews.ca/news/1125181...
Cellfie Project: Young IWK patients with leukemia get to see disease at cellular level - Halifax | Globalnews.ca
The largest children’s hospital in Atlantic Canada wants to make it easier for kids to understand their cancer diagnosis.
globalnews.ca
June 22, 2025 at 11:06 PM
Cellfie Project: Young IWK patients with leukemia get to see disease at cellular level globalnews.ca/news/1125181...