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This article introduces a new biomaterial concept termed “clickable dynamic bioinks”. These bioinks use dynamic hydrogels that can be 3D-bioprinted and chemically modified via click and bioorthogonal reactions to allow a variety of post-printing modifications. These modifications include adjusting the bioink composition and stiffness, as well as promoting cell adhesion, and can be controlled over time and space for 4D bioprinting applications. Abstract Bioprinting is a booming technology, with numerous applications in tissue engineering and regenerative medicine. However, most biomaterials designed for bioprinting depend on the use of sacrificial baths and/or non-physiological stimuli. Printable biomaterials also often lack tunability in terms of their composition and mechanical properties. To address these challenges, the authors introduce a new biomaterial concept that they have termed “clickable dynamic bioinks”. These bioinks use dynamic hydrogels that can be printed, as well as chemically modified via click reactions to fine-tune the physical and biochemical properties of printed objects after printing. Specifically, using hyaluronic acid (HA) as a polymer of interest, the authors investigate the use of a boronate ester-based crosslinking reaction to produce dynamic hydrogels that are printable and cytocompatible, allowing for bioprinting. The resulting dynamic bioinks are chemically modified with bioorthogonal click moieties to allow for a variety of post-printing modifications with molecules carrying the complementary click function. As proofs of concept, the authors perform various post-printing modifications, including adjusting polymer composition (e.g., HA, chondroitin sulfate, and gelatin) and stiffness, and promoting cell adhesion via adhesive peptide immobilization (i.e., RGD peptide). The results also demonstrate that these modifications can be controlled over time and space, paving the way for 4D bioprinting applications.

The use of 3D bioprinting to construct in vitro skeletal muscle models presents a promising approach

Dynamic growth factor presentation influences how individual endothelial cells assemble into complex

Regemat 3D has partnered with TheWell Bioscience to distribute VitroInk®, a cutting-edge bioink, enhancing their 3D bioprinting solutions across Europe.

The use of 3D bioprinting to construct in vitro skeletal muscle models presents a promising approach

This article introduces a new biomaterial concept termed “clickable dynamic bioinks”. These bioinks use dynamic hydrogels that can be 3D-bioprinted and chemically modified via click and bioorthogonal reactions to allow a variety of post-printing modifications. These modifications include adjusting the bioink composition and stiffness, as well as promoting cell adhesion, and can be controlled over time and space for 4D bioprinting applications. Abstract Bioprinting is a booming technology, with numerous applications in tissue engineering and regenerative medicine. However, most biomaterials designed for bioprinting depend on the use of sacrificial baths and/or non-physiological stimuli. Printable biomaterials also often lack tunability in terms of their composition and mechanical properties. To address these challenges, the authors introduce a new biomaterial concept that they have termed “clickable dynamic bioinks”. These bioinks use dynamic hydrogels that can be printed, as well as chemically modified via click reactions to fine-tune the physical and biochemical properties of printed objects after printing. Specifically, using hyaluronic acid (HA) as a polymer of interest, the authors investigate the use of a boronate ester-based crosslinking reaction to produce dynamic hydrogels that are printable and cytocompatible, allowing for bioprinting. The resulting dynamic bioinks are chemically modified with bioorthogonal click moieties to allow for a variety of post-printing modifications with molecules carrying the complementary click function. As proofs of concept, the authors perform various post-printing modifications, including adjusting polymer composition (e.g., HA, chondroitin sulfate, and gelatin) and stiffness, and promoting cell adhesion via adhesive peptide immobilization (i.e., RGD peptide). The results also demonstrate that these modifications can be controlled over time and space, paving the way for 4D bioprinting applications.

The presence of all-trans retinoic acid (atRA) in polycaprolactone (PCL) microparticles can promote the degradation of fibrin constructs. This highlights the need for a more careful consideration of ...