#Angiotensinogen
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nephjc.bsky.social
#NephJCshorts #MedSky #NephSky

✂️🌱Cutting the renin-angiotensin axis from the angiotensinogen roots using RNA interference via zilebesiran

✍️by @hswapnil.medsky.social

www.nephjc.com/news/2025/17...
NephJC Shorts: zilebesiran silencing hypertension via RNA interference — NephJC
the NephJC shorts version of the KARDIA1
www.nephjc.com
July 17, 2025 at 12:50 AM
rnflex.bsky.social
Up next metabolic markers and RAAS system: insulin, C-peptide, renin, angiotensinogen, and aldosterone

Calcium, phosphate, parathyroid hormone, vitamin D, ApoB, APoC3, NT-BNP,

Also "serum large-scale proteomic analysis will be performed to assess changes in protein metabolism"

Almost done!
October 30, 2025 at 11:26 PM
neuropjournal.bsky.social
New in #Neuroprotection:
How senescent #astrocytes affect the BBB 🧠🧬

✅ Young astrocytes enhance endothelial barrier function
✅ Senescent astrocytes ↑ angiotensinogen (AGT), losing this effect
✅ AGT knockdown restores barrier-promoting properties

t.co/rINteh1f9n
https://onlinelibrary.wiley.com/doi/10.1002/nep3.70013
t.co
October 11, 2025 at 3:44 AM
hvanspall.bsky.social
What’s new in #Antihypertensive therapies?
📍Aldosterone synthase inhibitors
📍Angiotensinogen targeted therapies
📍GLP1/GIP receptor agonists
📍Natriuretic peptide 1 receptor agonists
And more..
@circaha.bsky.social
buff.ly/4h45ULk www.ahajournals.org/doi/epub/10....
Future of Antihypertensive Therapies
buff.ly
January 5, 2025 at 1:19 PM
castltrastondrs.bsky.social
#MedSky🧪#IDSky #publichealth Vascular Pathogenesis in Acute and #LongCOVID: Current Insights and Therapeutic Outlook

www.thieme-connect.com/products/ejo...
VCAM-1, IL-1, and IL6 IL8 impaired fibrinolysis Platelet hyperactivation (acute / post-acute) Recruits Monocytes Interaction with Leukocytes Promotes Thrombosis Inhibition of tPA and uPA MCP1 fibrinogen & VWF E-selectin, ICAM-1,| VCAM-1)| Activation of extrinsic pathway of clotting Hours Days Invasion of endothelial cells by SARS CoV-2 during acute infection EC Activation Expression PAI1 and TF Immediate Reversible ED Type II Apoptosis Necrosis ED Viral Persistence SARS CoV-2 Endothelial Dysfunction Decreased ACE2 Irreversible ED Dysregulated Local RAS: * ↓ Decreased Endothelial Dysfunction Reversible Endothelial ACE2 receptor Factor Y PAI-1 Angiotensinogen Renin→ , ACE1 AT1 receptor Angiotensin | → Angiotensin II ACE2 + Angiotensin - - ACE2 A AT2 Angiosonsin receptor ACE1 Activity Capillary necroptosis Capillary rarefication Fig. 1 COVID-associated endothelial dysfunction and endothelialitis. Schematic representation of COVID-associated ED and endothelialitis.
October 7, 2024 at 12:46 AM
jordybc.bsky.social
Phase 2 trial of the new antihypertensive agent, ultra-long-acting (q6 month), subq, small interfering RNA against angiotensinogen (Zilebesiran), hit JAMA!

h/t @drjmluther.bsky.social

jamanetwork.com/journals/jam...

1/
Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension
This randomized clinical trial examines the efficacy and safety of zilebesiran vs placebo when added to a standard antihypertensive medication in adult patients with uncontrolled hypertension.
jamanetwork.com
May 28, 2025 at 8:09 PM
biochemsoc.bsky.social
Through detailed mechanistic investigation in angiotensinogen-deficient (Agt-KO) mice, Rodrigues et al. demonstrate that the severe anemia developed in RAS-deficient mice is exacerbated by iron deficiency, driven by hepcidin accumulation in blood. doi.org/10.1042/CS20...
Plasma iron homeostasis.
July 17, 2025 at 10:01 AM
ajvroa.bsky.social
Urinary angiotensinogen quantification is a promising noninvasive marker of intrarenal renin-angiotensin system activity.

Open access article: jav.ma/angio
September 30, 2025 at 8:40 PM
stratechdx.bsky.social
Featuring our partner #IBL Made in Japan specialised #ELISA and #Antibodies for #neurodegenerative, #kidney, #inflammatory and #metabolism disorders biomarkers #amyloid #angiotensinogen #klotho #incretin #GLP1 #GdIgA1 #nephropathy #glucose

Learn more here: www.stratech.co.uk/our-partners...
August 13, 2025 at 8:52 AM
stratechscientific.bsky.social
Essential #immunoassays from #ImmunoBiologicalLaboratories to study #kidney disease

Discover #Alpha-Klotho, #Gd-IgA1 & #Angiotensinogen (AGT) #ELISAs for #nephropathy & other kidney disorders

🔗https://tinyurl.com/mr23a3wj
January 29, 2025 at 12:59 PM
medrxivpreprint.bsky.social
Circulating Levels of Angiotensinogen, Sex, and Hormone Therapy - The Multi-Ethnic Study of Atherosclerosis (MESA) https://www.medrxiv.org/content/10.1101/2024.03.22.24304764v1
Circulating Levels of Angiotensinogen, Sex, and Hormone Therapy - The Multi-Ethnic Study of Atherosclerosis (MESA) https://www.medrxiv.org/content/10.1101/2024.03.22.24304764v1
Background: Angiotensinogen, the unique precursor of all angiotensin hormones of the Renin-Angiotens
www.medrxiv.org
March 25, 2024 at 2:58 AM
biorxivpreprint.bsky.social
Epigenetic and transcriptional regulation of the human angiotensinogen gene by high salt https://www.biorxiv.org/content/10.1101/2023.11.22.568343v1
Epigenetic and transcriptional regulation of the human angiotensinogen gene by high salt https://www.biorxiv.org/content/10.1101/2023.11.22.568343v1
Abstract: Hypertension is caused by a combination of genetic and environmental factors. Angiotensino
www.biorxiv.org
November 23, 2023 at 2:19 PM
stratechdx.bsky.social
Essential #immunoassays from #ImmunoBiologicalLaboratories to study #kidney disease. Discover #AlphaKlotho, #GdIgA1 and #Angiotensinogen (AGT) ELISAs for #nephropathy and other kidney disorders

🔗stratech.co.uk/our-p...

#assay #biotech #ELISA
November 4, 2025 at 8:00 AM
medrxivpreprint.bsky.social
Aldolase B and Angiotensinogen are associated with weekly chronic multisite spinal pain in men https://www.medrxiv.org/content/10.1101/2024.11.07.24316891v1
Aldolase B and Angiotensinogen are associated with weekly chronic multisite spinal pain in men https://www.medrxiv.org/content/10.1101/2024.11.07.24316891v1
Spinal pain problems increase with age, but already 21% of Finnish young adults suffer from a muscul
www.medrxiv.org
November 8, 2024 at 11:30 PM
mkeller7.bsky.social
See www.science.org/doi/10.1126/scitranslmed.aaq1787
A timeline of basic discoveries leading to FDA approval of imatinib. The discovery by Nowell and Hungerford in 1960 of the chromosomal translocation characteristic of CML, termed the Philadelphia chromosome, led to subsequent identification of the Bcr and Abl genes at the translocation junction. Next followed the demonstration that this translocation led to production of a fusion protein with constitutive Abl kinase activity. These discoveries ultimately informed the development of imatinib, which received FDA approval in 2001. A timeline of basic discoveries leading to FDA approval of the ACE inhibitor captopril. The role of the renin-angiotensin system in regulating blood pressure was discovered in 1898 by Tigerstedt and Bergman, who identified renin activity in kidney extracts. This discovery set the stage for the elucidation of the renin substrate, angiotensinogen (start of dark green shading), eventually leading to the development of captopril and other ACE inhibitors
February 9, 2025 at 10:27 PM
ajvroa.bsky.social
Our top trending #AJVR article last week was "Development and validation of a sandwich ELISA for measurement of angiotensinogen concentration in canine urine and serum": doi.org/10.2460/ajvr...
ajvroa.bsky.social American Journal of Veterinary Research (AJVR) @ajvroa.bsky.social · Sep 30
Urinary angiotensinogen quantification is a promising noninvasive marker of intrarenal renin-angiotensin system activity.

Open access article: jav.ma/angio
October 7, 2025 at 7:01 PM
single-molecule.bsky.social
#AGBTGM #AGBT2025 #AGBT25 RL: potassium also related to BP, if reduce K, get less reabsorption of Na, siRNA from Alnylam targeted against angiotensinogen in liver can lower by 95% and lower BP for 3 months
February 24, 2025 at 2:07 PM
uwnephrology.bsky.social
Dr. Katherine Tuttle focuses her educational Grand Rounds talk on a reemerging topic: "New Approaches to Blocking #Aldosterone & #Angiotensinogen for #Hypertension or #CKD." #kidney #nephrology #nephsky
@uwmedicine.bsky.social

youtu.be/TeWkmCopuzk
Kathy Tuttle, MD - New Approaches to Blocking Aldosterone & Angiotensinogen for Hypertension or CKD
YouTube video by University of Washington Division of Nephrology
youtu.be
May 9, 2025 at 8:11 PM
ronbeavis.mastodon.social.ap.brid.gy
AGT:p (angiotensinogen) is a whopper of a proprotein (25-485) that is secreted by the liver and the CNS. One of either Angiotensin 1 (25-34), 2 (25-32), 3 (26-32) or 4 (27-32) is cleaved off the N-terminus of the protein. The remnant without angiotensin […]

[Original post on mastodon.social]
August 21, 2024 at 11:52 AM
stratechdx.bsky.social
Essential #immunoassays from Immuno-Biological Laboratories to study #kidney disease

Discover #Alpha-Klotho, #Gd-IgA1 & #Angiotensinogen (AGT) ELISAs for #nephropathy and other kidney disorders

🔗www.stratech.co.uk/o...

#diagnostics #clinicaldiagnostics #biosciences #labtech
October 21, 2025 at 7:00 AM
amjhypertension.bsky.social
#WeekendReads

From the #EditorsChoice archives

A Possible Interaction Between Systemic and Renal Angiotensinogen in the Control of Blood Pressure ? In 🐀

🔗 academic.oup.com/ajh/article/...
academic.oup.com
June 15, 2025 at 10:18 AM
stratechscientific.bsky.social
Featuring our partner #IBL specialised #ELISA and #Antibodies for #neurodegenerative, #kidney, #inflammatory and #metabolism disorders biomarkers #amyloid #angiotensinogen #klotho #incretin #GLP1 #GdIgA1 #nephropathy #glucose

Find out more here: www.stratech.co.uk/our-partners...
June 4, 2025 at 8:37 AM
biorxiv-molbio.bsky.social
Epigenetic and transcriptional regulation of the human angiotensinogen gene by high salt https://www.biorxiv.org/content/10.1101/2023.11.22.568343v1
Epigenetic and transcriptional regulation of the human angiotensinogen gene by high salt https://www.biorxiv.org/content/10.1101/2023.11.22.568343v1
Abstract: Hypertension is caused by a combination of genetic and environmental factors. Angiotensino
www.biorxiv.org
November 23, 2023 at 2:19 PM
biorxiv-pharma.bsky.social
Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms https://www.biorxiv.org/content/10.1101/2025.05.05.652275v1
May 10, 2025 at 2:01 AM