#LRP1‑targeted #polymersomes reprogram #BloodBrainBarrier trafficking, enabling rapid #Amyloidβ clearance and sustained cognitive recovery in #AlzheimersDisease models. @beppebattaglia.bsky.social @ucl.ac.uk @icta-uab.bsky.social
#CoverPage in #STTT: doi.org/10.1038/s413...
#CoverPage in #STTT: doi.org/10.1038/s413...
January 3, 2026 at 1:00 PM
#LRP1‑targeted #polymersomes reprogram #BloodBrainBarrier trafficking, enabling rapid #Amyloidβ clearance and sustained cognitive recovery in #AlzheimersDisease models. @beppebattaglia.bsky.social @ucl.ac.uk @icta-uab.bsky.social
#CoverPage in #STTT: doi.org/10.1038/s413...
#CoverPage in #STTT: doi.org/10.1038/s413...
OHSU researchers have identified an enzyme associated with disorders ranging from #MultipleSclerosis to neurodegenerative conditions like #AlzheimersDisease. https://www.news-medical.net/news/20251211/Researchers-identify-enzyme-linked-to-myelin-damage-and-neurodegenerative-conditions.aspx
Researchers identify enzyme linked to myelin damage and neurodegenerative conditions
Researchers at Oregon Health & Science University have identified a type of enzyme with a complicated name - cell migration inducing and hyaluronan-binding protein, or CEMIP - is associated with disorders ranging from multiple sclerosis to stroke to neu...
www.news-medical.net
December 31, 2025 at 10:41 PM
OHSU researchers have identified an enzyme associated with disorders ranging from #MultipleSclerosis to neurodegenerative conditions like #AlzheimersDisease. https://www.news-medical.net/news/20251211/Researchers-identify-enzyme-linked-to-myelin-damage-and-neurodegenerative-conditions.aspx
An updated overview of AD mechanisms, diagnostics, and evolving therapeutic strategies.
#AlzheimersDisease #Neurodegeneration #DementiaResearch #ADMechanisms
www.nature.com/articles/s41...
#AlzheimersDisease #Neurodegeneration #DementiaResearch #ADMechanisms
www.nature.com/articles/s41...
December 30, 2025 at 12:16 PM
An updated overview of AD mechanisms, diagnostics, and evolving therapeutic strategies.
#AlzheimersDisease #Neurodegeneration #DementiaResearch #ADMechanisms
www.nature.com/articles/s41...
#AlzheimersDisease #Neurodegeneration #DementiaResearch #ADMechanisms
www.nature.com/articles/s41...
Multivalent nanomedicine targeting LRP1 at the blood–brain barrier accelerates amyloid-β clearance and restores cognitive function in Alzheimer’s models.
#AlzheimersDisease #AmyloidBeta #BloodBrainBarrier #Nanomedicine #Neurodegeneration
www.nature.com/articles/s41...
#AlzheimersDisease #AmyloidBeta #BloodBrainBarrier #Nanomedicine #Neurodegeneration
www.nature.com/articles/s41...
December 30, 2025 at 12:15 PM
Multivalent nanomedicine targeting LRP1 at the blood–brain barrier accelerates amyloid-β clearance and restores cognitive function in Alzheimer’s models.
#AlzheimersDisease #AmyloidBeta #BloodBrainBarrier #Nanomedicine #Neurodegeneration
www.nature.com/articles/s41...
#AlzheimersDisease #AmyloidBeta #BloodBrainBarrier #Nanomedicine #Neurodegeneration
www.nature.com/articles/s41...
Interesting Research! For more than a century, people have considered #AlzheimersDisease irreversible. Researchers Andrew Pieper, et al. have now challenged this dogma testing whether brains already badly afflicted w/ #Alzheimers could recover @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain
Chaubey et al. demonstrate that restoration of brain resilience reverses advanced
disease in two different mouse models of Alzheimer’s disease (AD), challenging the
century-long dogma of AD irreversib...
www.cell.com
December 29, 2025 at 7:24 PM
Interesting Research! For more than a century, people have considered #AlzheimersDisease irreversible. Researchers Andrew Pieper, et al. have now challenged this dogma testing whether brains already badly afflicted w/ #Alzheimers could recover @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
"Andrew was diagnosed with young-onset #AlzheimersDisease, a rare variant form called posterior cortical #atrophy, or #PCA. Before this, I had never even heard of PCA. Now it defines our lives.": buff.ly/Mb87gSq
via globeandmail
#ProgressiveDisease #marriage
via globeandmail
#ProgressiveDisease #marriage
The shift from wife to caregiver was instant and soul crushing
My heart broke as I realized life is changing, but despite that we are still a team, just now navigating uncharted waters
buff.ly
December 27, 2025 at 5:30 PM
"Andrew was diagnosed with young-onset #AlzheimersDisease, a rare variant form called posterior cortical #atrophy, or #PCA. Before this, I had never even heard of PCA. Now it defines our lives.": buff.ly/Mb87gSq
via globeandmail
#ProgressiveDisease #marriage
via globeandmail
#ProgressiveDisease #marriage
Experimental drug developed by researchers Daniel Kranz, William Klein, et al. @nufeinbergmed.bsky.social has shown further promise as an early intervention for #AlzheimersDisease. Learn More in #Alzheimers & #Dementia @alzassociation.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
December 26, 2025 at 3:15 PM
Experimental drug developed by researchers Daniel Kranz, William Klein, et al. @nufeinbergmed.bsky.social has shown further promise as an early intervention for #AlzheimersDisease. Learn More in #Alzheimers & #Dementia @alzassociation.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Scientists pioneer BBB-targeted #nanomedicine using #LRP1-polymersomes to boost #Amyloidβ clearance, improve cognition in #AlzheimersDisease mice, and establish LRP1 trafficking as therapy. @beppebattaglia.bsky.social @ucl.ac.uk @icta-uab.bsky.social
#STTT: doi.org/10.1038/s413...
#STTT: doi.org/10.1038/s413...
December 24, 2025 at 11:03 PM
Scientists pioneer BBB-targeted #nanomedicine using #LRP1-polymersomes to boost #Amyloidβ clearance, improve cognition in #AlzheimersDisease mice, and establish LRP1 trafficking as therapy. @beppebattaglia.bsky.social @ucl.ac.uk @icta-uab.bsky.social
#STTT: doi.org/10.1038/s413...
#STTT: doi.org/10.1038/s413...
This is such great work! 🧠
#neuroscience #Alzheimersdisease #science #nature #cell
www.cell.com/cell-reports...
#neuroscience #Alzheimersdisease #science #nature #cell
www.cell.com/cell-reports...
Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain
Chaubey et al. demonstrate that restoration of brain resilience reverses advanced
disease in two different mouse models of Alzheimer’s disease (AD), challenging the
century-long dogma of AD irreversib...
www.cell.com
December 24, 2025 at 9:29 PM
This is such great work! 🧠
#neuroscience #Alzheimersdisease #science #nature #cell
www.cell.com/cell-reports...
#neuroscience #Alzheimersdisease #science #nature #cell
www.cell.com/cell-reports...
📰Check out our series of Issues thematically aligned with the expertise of our academic editors
Explore the 'In the Limelight' series
🔦https://buff.ly/4b4aRkm
#AlzheimersDisease #RNAbiology #Glycosphingolipids #Neurotransmitter #Antivirals #Lysosomes #Condensates #Bioplastics
Explore the 'In the Limelight' series
🔦https://buff.ly/4b4aRkm
#AlzheimersDisease #RNAbiology #Glycosphingolipids #Neurotransmitter #Antivirals #Lysosomes #Condensates #Bioplastics
December 23, 2025 at 1:40 PM
📰Check out our series of Issues thematically aligned with the expertise of our academic editors
Explore the 'In the Limelight' series
🔦https://buff.ly/4b4aRkm
#AlzheimersDisease #RNAbiology #Glycosphingolipids #Neurotransmitter #Antivirals #Lysosomes #Condensates #Bioplastics
Explore the 'In the Limelight' series
🔦https://buff.ly/4b4aRkm
#AlzheimersDisease #RNAbiology #Glycosphingolipids #Neurotransmitter #Antivirals #Lysosomes #Condensates #Bioplastics
Toxic Mold: The Hidden Threat to Your Brain 🧠
#biohacking #toxicmold #brainhealth #biohackingtips #alzheimersprevention #parkinsonsawareness #healthyliving #moldtoxins #healthtips #DNA #neurology #diseaseprevention #moldawareness #mouldf="/hashtag/mould" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#mould #mould #alzheimersawareness #alzheimersdisease
#biohacking #toxicmold #brainhealth #biohackingtips #alzheimersprevention #parkinsonsawareness #healthyliving #moldtoxins #healthtips #DNA #neurology #diseaseprevention #moldawareness #mouldf="/hashtag/mould" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#mould #mould #alzheimersawareness #alzheimersdisease
December 22, 2025 at 8:04 PM
Toxic Mold: The Hidden Threat to Your Brain 🧠
#biohacking #toxicmold #brainhealth #biohackingtips #alzheimersprevention #parkinsonsawareness #healthyliving #moldtoxins #healthtips #DNA #neurology #diseaseprevention #moldawareness #mouldf="/hashtag/mould" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#mould #mould #alzheimersawareness #alzheimersdisease
#biohacking #toxicmold #brainhealth #biohackingtips #alzheimersprevention #parkinsonsawareness #healthyliving #moldtoxins #healthtips #DNA #neurology #diseaseprevention #moldawareness #mouldf="/hashtag/mould" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#mould #mould #alzheimersawareness #alzheimersdisease
C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline
Brijendra Singh, Andre F. Batista, Emma T. Spooner...Cynthia A. Lemere @harvardmed.bsky.social #AlzheimersDisease #complement #amyloid #neuroinflammation
link.springer.com/article/10.1...
Brijendra Singh, Andre F. Batista, Emma T. Spooner...Cynthia A. Lemere @harvardmed.bsky.social #AlzheimersDisease #complement #amyloid #neuroinflammation
link.springer.com/article/10.1...
C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline - Molecular Neurodegeneration Advances
Background We previously reported that germline complement C3 deletion protected cognition and hippocampal synapses in aged APP/PS1dE9 mice despite increased amyloid plaques. To assess whether global ...
link.springer.com
December 22, 2025 at 2:22 PM
C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline
Brijendra Singh, Andre F. Batista, Emma T. Spooner...Cynthia A. Lemere @harvardmed.bsky.social #AlzheimersDisease #complement #amyloid #neuroinflammation
link.springer.com/article/10.1...
Brijendra Singh, Andre F. Batista, Emma T. Spooner...Cynthia A. Lemere @harvardmed.bsky.social #AlzheimersDisease #complement #amyloid #neuroinflammation
link.springer.com/article/10.1...
Researchers Nicole F. O. Green, Gavin Sutton, Irina Voineagu, et al. at UNSW have revealed so-called “junk DNA” contains powerful switches that help control brain cells linked to #AlzheimersDisease. Learn More In Nature Neuroscience @natureportfolio.nature.com 👉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CRISPRi screening in cultured human astrocytes uncovers distal enhancers controlling genes dysregulated in Alzheimer’s disease - Nature Neuroscience
This study reveals how distal DNA ‘switches’ control gene activity in human astrocytes. Using CRISPRi screens and single-cell RNA-seq, we map enhancer–gene links, highlight Alzheimer’s disease-related...
www.nature.com
December 19, 2025 at 7:11 PM
Researchers Nicole F. O. Green, Gavin Sutton, Irina Voineagu, et al. at UNSW have revealed so-called “junk DNA” contains powerful switches that help control brain cells linked to #AlzheimersDisease. Learn More In Nature Neuroscience @natureportfolio.nature.com 👉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#Sleepissues in adults with #DownSyndrome (DS) are often overlooked or under reported. This study examines #OSA and #sleepdisruptions with prevalence of symptoms of #AlzheimersDisease in older adults with #DS. academic.oup.com/sleepadvance...
Preliminary investigation of obstructive sleep apnea and Alzheimer’s disease in down syndrome
Abstract. This study provided a preliminary examination of indices of obstructive sleep apsnea (OSA) and sleep disruptions in adults with Down syndrome (DS
academic.oup.com
December 19, 2025 at 2:11 PM
#Sleepissues in adults with #DownSyndrome (DS) are often overlooked or under reported. This study examines #OSA and #sleepdisruptions with prevalence of symptoms of #AlzheimersDisease in older adults with #DS. academic.oup.com/sleepadvance...
The #ExperimentalDrug NU-9 significantly reduced toxic #AmyloidBeta oligomers and related #NeuronalDamage in a mouse model of #AlzheimersDisease, demonstrating potential as an early #TherapeuticIntervention.
Experimental drug NU-9 halts Alzheimer’s disease in animal model before symptoms begin – BioNews Central
The experimental drug NU-9 significantly reduced toxic amyloid beta oligomers and related neuronal damage in a mouse model of Alzheimer's disease, demonstrating potential as an early therapeutic intervention. ...
sbee.link
December 18, 2025 at 8:34 PM
The #ExperimentalDrug NU-9 significantly reduced toxic #AmyloidBeta oligomers and related #NeuronalDamage in a mouse model of #AlzheimersDisease, demonstrating potential as an early #TherapeuticIntervention.
⚡Our December issue is live! Check out our Year in Review for 2025 highlights and a what to look out for in 2026; also featuring news, opinioin & new research on #agingclocks, #liquidbiopsies, #Alzheimersdisease, #PCOS, #sepsis, & more.
Read it here: https://www.nature.com/nm/volumes/31/issues/12
Read it here: https://www.nature.com/nm/volumes/31/issues/12
December 18, 2025 at 12:53 PM
⚡Our December issue is live! Check out our Year in Review for 2025 highlights and a what to look out for in 2026; also featuring news, opinioin & new research on #agingclocks, #liquidbiopsies, #Alzheimersdisease, #PCOS, #sepsis, & more.
Read it here: https://www.nature.com/nm/volumes/31/issues/12
Read it here: https://www.nature.com/nm/volumes/31/issues/12
New Alzheimer’s treatments are changing care. This #CME covers patient selection, safe initiation, side effect monitoring, and shared decision making with patients and caregivers. 🧠📚
Register now to earn CME credit: bit.ly/4qevGkN
#MedicalEducation #AlzheimersDisease #Neurology #DementiaCare
Register now to earn CME credit: bit.ly/4qevGkN
#MedicalEducation #AlzheimersDisease #Neurology #DementiaCare
December 16, 2025 at 10:00 PM
New Alzheimer’s treatments are changing care. This #CME covers patient selection, safe initiation, side effect monitoring, and shared decision making with patients and caregivers. 🧠📚
Register now to earn CME credit: bit.ly/4qevGkN
#MedicalEducation #AlzheimersDisease #Neurology #DementiaCare
Register now to earn CME credit: bit.ly/4qevGkN
#MedicalEducation #AlzheimersDisease #Neurology #DementiaCare
The #complement cascade in #AlzheimersDisease: modern implications of an ancient #immune protagonist
Maria-Tzousi Papavergi, Praveen Bathini, Brijendra Singh & Cynthia A. Lemere @harvardmed.bsky.social
link.springer.com/article/10.1...
Maria-Tzousi Papavergi, Praveen Bathini, Brijendra Singh & Cynthia A. Lemere @harvardmed.bsky.social
link.springer.com/article/10.1...
The complement cascade in Alzheimer’s disease: modern implications of an ancient immune protagonist - Molecular Neurodegeneration
Molecular Neurodegeneration - The complement system, a critical arm of innate immunity, has emerged as a key contributor to the pathogenesis of Alzheimer’s disease (AD). While...
link.springer.com
December 16, 2025 at 1:40 PM
The #complement cascade in #AlzheimersDisease: modern implications of an ancient #immune protagonist
Maria-Tzousi Papavergi, Praveen Bathini, Brijendra Singh & Cynthia A. Lemere @harvardmed.bsky.social
link.springer.com/article/10.1...
Maria-Tzousi Papavergi, Praveen Bathini, Brijendra Singh & Cynthia A. Lemere @harvardmed.bsky.social
link.springer.com/article/10.1...
Final day in London, doing Biddy stuff. A tough time with just a couple of days off. #AlzheimersDisease divides & separates even loving families, & separation is even greater at this time. With Biddy virtually camped with Dad for Xmas, time to go back & write the next book.
December 16, 2025 at 8:48 AM
Final day in London, doing Biddy stuff. A tough time with just a couple of days off. #AlzheimersDisease divides & separates even loving families, & separation is even greater at this time. With Biddy virtually camped with Dad for Xmas, time to go back & write the next book.
Dr. Larry Sherman, professor at OHSU’s Oregon National Primate Research Center, led research identifying the enzyme CEMIP as a key player in #myelin breakdown linked to conditions like #AlzheimersDisease. https://news.ohsu.edu/2025/12/11/study-implicates-enzyme-in-neurodegenerative-conditions
Study implicates enzyme in neurodegenerative conditions
OHSU research finds a specific enzyme is involved in myelin breakdown that causes conditions such as MS, stroke, Alzheimer's.
news.ohsu.edu
December 15, 2025 at 11:29 PM
Dr. Larry Sherman, professor at OHSU’s Oregon National Primate Research Center, led research identifying the enzyme CEMIP as a key player in #myelin breakdown linked to conditions like #AlzheimersDisease. https://news.ohsu.edu/2025/12/11/study-implicates-enzyme-in-neurodegenerative-conditions
Early, sex-dependent and progressive proteomic imbalance in the amygdala during Alzheimers disease progression
Anaya-Cubero, E. et al.
Paper
Details
#AlzheimersDisease #Proteomics #AmygdalaResearch
Anaya-Cubero, E. et al.
Paper
Details
#AlzheimersDisease #Proteomics #AmygdalaResearch
December 15, 2025 at 1:42 AM
Early, sex-dependent and progressive proteomic imbalance in the amygdala during Alzheimers disease progression
Anaya-Cubero, E. et al.
Paper
Details
#AlzheimersDisease #Proteomics #AmygdalaResearch
Anaya-Cubero, E. et al.
Paper
Details
#AlzheimersDisease #Proteomics #AmygdalaResearch
Dad day - we had tea & biscuits, some chat and some sleep - well lots of sleep. With so much to do for Biddy, it might be the last visit this trip. Parent rationing at the end of a trip is always difficult. #AlzheimersDisease
December 14, 2025 at 11:28 PM
Dad day - we had tea & biscuits, some chat and some sleep - well lots of sleep. With so much to do for Biddy, it might be the last visit this trip. Parent rationing at the end of a trip is always difficult. #AlzheimersDisease
Bone marrow B cells accelerate Aβ pathology & microglial reactivity by promoting HSCs/ABCs via IL-6 suggesting that IL-6R #Immunotherapy targeting B cells may benefit early #AlzheimersDisease patients. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
December 13, 2025 at 12:30 PM
Bone marrow B cells accelerate Aβ pathology & microglial reactivity by promoting HSCs/ABCs via IL-6 suggesting that IL-6R #Immunotherapy targeting B cells may benefit early #AlzheimersDisease patients. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
#STTT #OpenAccess: doi.org/10.1038/s413...
Follow @biohackingpathway for more
#LessSocialMediaMoreLifecialMediaMoreLife" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#LessSocialMediaMoreLife #MisfoldedProteins #ProteinFolding #Type2Diabetes #AlzheimersDisease #MetabolicSyndrome #wellnessatwork #wellnessquotes #physicalwellbeing #Health #Science #MedicalResearch #Disease #LessSocialMediaMoreLife
#LessSocialMediaMoreLifecialMediaMoreLife" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#LessSocialMediaMoreLife #MisfoldedProteins #ProteinFolding #Type2Diabetes #AlzheimersDisease #MetabolicSyndrome #wellnessatwork #wellnessquotes #physicalwellbeing #Health #Science #MedicalResearch #Disease #LessSocialMediaMoreLife
December 13, 2025 at 12:07 PM
Follow @biohackingpathway for more
#LessSocialMediaMoreLifecialMediaMoreLife" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#LessSocialMediaMoreLife #MisfoldedProteins #ProteinFolding #Type2Diabetes #AlzheimersDisease #MetabolicSyndrome #wellnessatwork #wellnessquotes #physicalwellbeing #Health #Science #MedicalResearch #Disease #LessSocialMediaMoreLife
#LessSocialMediaMoreLifecialMediaMoreLife" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#LessSocialMediaMoreLife #MisfoldedProteins #ProteinFolding #Type2Diabetes #AlzheimersDisease #MetabolicSyndrome #wellnessatwork #wellnessquotes #physicalwellbeing #Health #Science #MedicalResearch #Disease #LessSocialMediaMoreLife
Metabolic dysregulation in Alzheimer’s is worse in female brains #Science #HealthandMedicine #Neurology #AlzheimersDisease #MetabolicDysregulation #WomenInScience
Metabolic dysregulation in Alzheimer’s is worse in female brains
A biochemical analysis of brains of deceased individuals with Alzheimer’s disease found markers of impaired insulin signaling and impaired mitochondrial function. Analyses also indicated altered neuroinflammation...
purescience.news
December 13, 2025 at 6:30 AM
Metabolic dysregulation in Alzheimer’s is worse in female brains #Science #HealthandMedicine #Neurology #AlzheimersDisease #MetabolicDysregulation #WomenInScience