Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates XPO1 degradation through an allosteric molecule glue mec...

**Abstract:** Microbial electron transport chains (METCs) are vital for energy production in anaerobic environments. While classical models predominantly describe them as sequential redox events, recent evidence suggests a crucial role for quantum coherence in facilitating efficient electron transfer, particularly under fluctuating environmental conditions. This research proposes a novel bio-inspired algorithmic framework, "Adaptive Resonance Dynamics" (ARD), that simulates and optimizes METC performance by dynamically modulating enzyme allostery to preserve quantum coherence across multiple redox centers.

While not a Nobel prize-winning discovery in itself, this challenge to the reductionist view of physiology has links to several other winners

PhD Project - EASTBIO: Probing allostery and dynamics in ATP phosphoribosyltransferase with ensemble and single-molecule enzymology at University of St Andrews, listed on FindAPhD.com

**Abstract:** Protein allostery, the regulation of protein function through conformational changes induced by distal binding events, presents a formidable challenge for drug design. Existing computational models often struggle to accurately capture the dynamic nature of allosteric networks. This research introduces a novel framework utilizing multi-modal data fusion (X-ray crystallography, cryo-EM, molecular dynamics simulations, and fluorescence resonance energy transfer – FRET), integrated with reinforcement learning (RL), to reconstruct dynamic allosteric networks and predict drug efficacy.

In 1965, the discovery of a mechanism known as allostery revolutionized our understanding of regulation in molecular biology. Sixty years on, we look back at a scientific and human journey that ushere...

Heat shock protein 90 (Hsp90) serves as a crucial regulator of cellular proteostasis by stabilizing and regulating the activity of numerous substrates, many of which are oncogenic proteins. Therefore,...

YouTube video by the bumbling biochemist

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