In today’s digital ecosystem, organisations in Australia face escalating cyber-risks and a compliance landscape that is shifting rapidly. This makes it vital for businesses, especially small and mediu...

H2 is an ideal energy vector, but catalysts for its clean production from water are inefficient or expensive. [FeFe]-hydrogenases are the most active H2-converting catalysts in nature, using a unique ...

ACSC Semi-Finals: Lighthouse Warriors vs. Evangel Christian Lightning BROADCAST TEAM: Matt Holmes - Play by Play Wesley Homes - Color Commentary Kirk

Design of modular, transferable protein assemblies has broad applicability and in structural biology could help with the ever-troublesome crystallization bottleneck, including finding robustly behaved...

Design of modular, transferable protein assemblies has broad applicability and in structural biology could help with the ever-troublesome crystallization bottleneck, including finding robustly behaved protein crystals for rapidly characterizing ligands or drug candidates or generating multiple polymorphs to illuminate diverse conformations. Nanobodies as crystallization chaperones are well-established but still unreliable, as we show here. Instead, we show an exemplar of how robust crystallization behavior can be engineered by exploring many combinations (>200) of nanobody surface mutations over several iterations. Critically, what needed testing was crystallization and diffraction quality, since target–nanobody binding affinity is decoupled from crystallizability enhancement. Our study yielded multiple polymorphs, all mediated by the same interface, with dramatically improved resolution and diffraction reliability for some mutants; we thus name them ‘Gluebodies’ (Gbs). We further demonstrate that these Gb mutations do transfer to some other targets, both for achieving robust crystallization in alternative packing forms and for establishing the ability to crystallize a key early stage readout. Since the Gb interface is evidently a favored interaction, it may be broadly applicable for modular assembly; more specifically, this work suggests that Gbs should be routinely attempted for crystallization whenever nanobodies are available.

Heme-dependent tyrosine hydroxylases (TyrH) are critical enzymes in catecholamine biosynthesis, yet the role of the substrate’s α-amino group in their monooxygenation mechanism has been unclear. Usin...

Essential Privacy and Regulatory Research at Your Fingertips. Find everything you need to stay up-to-date on evolving privacy & security regulations around the world

Read the latest: ACSC reports surge in cyberattacks targeting Australia's critical infrastructure, focus shifts to building resilience on Industrial Cyber. Explore insights, analysis, and news about A...

Read the latest: ACSC reports surge in cyberattacks targeting Australia's critical infrastructure, focus shifts to building resilience on Industrial Cyber. Explore insights, analysis, and news about…

Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...

The 2024-2025 Australian Cyber Threat Report reveals a significant increase in cybersecurity incidents and costs, driven by cybercrime and state-sponsored actors.

Essential Privacy and Regulatory Research at Your Fingertips. Find everything you need to stay up-to-date on evolving privacy & security regulations around the world

【シドニー時事】オーストラリア航空最大手のカンタス航空は１２日付で、７月にサイバー攻撃を受けた際に漏えいした約５７０万人の顧客情報が闇のウェブサイトに掲載されたことを明らかにした。ハッカー集団は...

You have been invited to Waveful by @Jzilversmit88, what an honour 🥰

We report a method to convert discrete representations of molecules to and from a multidimensional continuous representation. This model allows us to generate new molecules for efficient exploration a...