Hey @MaverickNY .... maybe we’ve been wrong all along.
#AACR18 #ASCO18 #ComicSans https://twitter.com/roelverhaak/status/991265124911648768
#AACR18 #ASCO18 #ComicSans https://twitter.com/roelverhaak/status/991265124911648768
December 2, 2024 at 8:26 PM
Hey @MaverickNY .... maybe we’ve been wrong all along.
#AACR18 #ASCO18 #ComicSans https://twitter.com/roelverhaak/status/991265124911648768
#AACR18 #ASCO18 #ComicSans https://twitter.com/roelverhaak/status/991265124911648768
I'm sure that this was probably fun to do, but from my vantage point, it looked incredibly creepy and dystopian. #AACR18 #CyberDetailing #YouWillBeAssimilated
December 2, 2024 at 8:25 PM
I'm sure that this was probably fun to do, but from my vantage point, it looked incredibly creepy and dystopian. #AACR18 #CyberDetailing #YouWillBeAssimilated
.@pkuhn1 you had to leave before our presentation, but I assure you that your Working Group 3 rocked, and @bigjerm823 was the best!
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:56 AM
.@pkuhn1 you had to leave before our presentation, but I assure you that your Working Group 3 rocked, and @bigjerm823 was the best!
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
Dr Pardoll: Rick Pazdur of @FDAOncology has been instrumental in accelerating the pace of approval in the immunotherapy space and deserves major kudos for this.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:56 AM
Dr Pardoll: Rick Pazdur of @FDAOncology has been instrumental in accelerating the pace of approval in the immunotherapy space and deserves major kudos for this.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
The immune system has a memory, which means there can be a durable response to a course of therapy.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:56 AM
The immune system has a memory, which means there can be a durable response to a course of therapy.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
MSI high is kinda like not having a functioning spellcheck while transcribing War and Peace. (This ismenthyoingnwithiur soelkcheck)
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
MSI high is kinda like not having a functioning spellcheck while transcribing War and Peace. (This ismenthyoingnwithiur soelkcheck)
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
Microsattelite instability is a defect in the cells ability to repair DNA damage when cells are dividing & DNA is being copied. This leads to LOTS of mutations that the immune system can recognize, which is why MSI high tumors respond so well to immunotherapy. #AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
Microsattelite instability is a defect in the cells ability to repair DNA damage when cells are dividing & DNA is being copied. This leads to LOTS of mutations that the immune system can recognize, which is why MSI high tumors respond so well to immunotherapy. #AACRSSP18 #AACR18
Tumor specific antigens uniquely mark the cancer cell as different, and T cells can thereby recognize the cell as foreign and try to eliminate it
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
Tumor specific antigens uniquely mark the cancer cell as different, and T cells can thereby recognize the cell as foreign and try to eliminate it
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
December 2013 immunotherapy was touted as the breakthrough of the year. Five years later is is still the hottest topic, but not mature. When it works, it's amazing, but toxicities can be significant.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
December 2013 immunotherapy was touted as the breakthrough of the year. Five years later is is still the hottest topic, but not mature. When it works, it's amazing, but toxicities can be significant.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
Completely blocking CTLA4 or PD1 lead to rapid death in mice. But partial blockade, maybe, could kill the cancer without the killing the patient. Yervoy is an anti- CTLA4 and Opdivo and Keytruda are a anti-PD1.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
Completely blocking CTLA4 or PD1 lead to rapid death in mice. But partial blockade, maybe, could kill the cancer without the killing the patient. Yervoy is an anti- CTLA4 and Opdivo and Keytruda are a anti-PD1.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
This is only a small number of the molecules that regulate the T cell immune response, including CTLA4 and PD1, both of which put the brakes on immune response #AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
This is only a small number of the molecules that regulate the T cell immune response, including CTLA4 and PD1, both of which put the brakes on immune response #AACRSSP18 #AACR18
Melanoma is a great case study of the promise of immunotherapy; there are lots of tumor infiltrating lymphocytes that have anticsncer activity in vitro, but in vivo, the cancer throws up defensive walks that need to be broken down first
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
Melanoma is a great case study of the promise of immunotherapy; there are lots of tumor infiltrating lymphocytes that have anticsncer activity in vitro, but in vivo, the cancer throws up defensive walks that need to be broken down first
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
T cells and antibodies we have in our bodies are like having millions of anticancer weapons. Dr Pardoll.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
T cells and antibodies we have in our bodies are like having millions of anticancer weapons. Dr Pardoll.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
The immune system: the perfect anti cancer agent (except for those nasty and potentially life threatening side effects) #AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
The immune system: the perfect anti cancer agent (except for those nasty and potentially life threatening side effects) #AACRSSP18 #AACR18
This NYC doc, gave people bacteria (called Coley's toxins) which stimulated an immune response which helped some cancers
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
This NYC doc, gave people bacteria (called Coley's toxins) which stimulated an immune response which helped some cancers
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
First immunotherapy done in early 1900s in NYC, took a looonnnnggg time to get where we are now, but field has exploded in the last few years
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
First immunotherapy done in early 1900s in NYC, took a looonnnnggg time to get where we are now, but field has exploded in the last few years
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
Dr Pazdur of @FDAOncology : who cares about what happens in the artificial environment of a clinical trial? We need to know how the drug will work in the real world.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
Dr Pazdur of @FDAOncology : who cares about what happens in the artificial environment of a clinical trial? We need to know how the drug will work in the real world.
#AACRSSP18 #AACR18
#AACRSSP18 #AACR18
ThNks to he 21stcentury cures act, patient reported outcomes MUST be reviewed by @FDAOncology #AACRSSP18 #AACR18
November 19, 2024 at 1:57 AM
ThNks to he 21stcentury cures act, patient reported outcomes MUST be reviewed by @FDAOncology #AACRSSP18 #AACR18
And @METUPorg a d @metavivor get a shout out from @FDAOncology @tmprowell, a great friend of advocates #AACRSSP18 #AACR18
November 19, 2024 at 2:16 AM
And @METUPorg a d @metavivor get a shout out from @FDAOncology @tmprowell, a great friend of advocates #AACRSSP18 #AACR18
.love that we advocates are able to have a dialogue with @FDAOncology deputy commissioner Anna Abrahms, who agrees that stage appropriate advocates should be more involved. #AACRSSP18 #AACR18
November 19, 2024 at 2:16 AM
.love that we advocates are able to have a dialogue with @FDAOncology deputy commissioner Anna Abrahms, who agrees that stage appropriate advocates should be more involved. #AACRSSP18 #AACR18