David Zorko, MD MSc
@zorkosaurus.bsky.social
#PedsICU Intensivist/Assistant Prof @MacUPediatrics McMaster Children’s Hospital. Researches #PICSp #CCI & survivorship. Reads comics and still eats Eggos.
🟠Moderate certainty evidence that DXM has little/no effect on duration of mechanical ventilation, clinically important bradycardia, or clinically important hypotension
🔴Low certainty evidence for reduction in delirium
⚫Very low certainty evidence for impact on withdrawal and long-term outcomes
🔴Low certainty evidence for reduction in delirium
⚫Very low certainty evidence for impact on withdrawal and long-term outcomes
September 24, 2025 at 8:30 PM
🟠Moderate certainty evidence that DXM has little/no effect on duration of mechanical ventilation, clinically important bradycardia, or clinically important hypotension
🔴Low certainty evidence for reduction in delirium
⚫Very low certainty evidence for impact on withdrawal and long-term outcomes
🔴Low certainty evidence for reduction in delirium
⚫Very low certainty evidence for impact on withdrawal and long-term outcomes
Key findings:
➡️12 RCTs, 592 participants
➡️Variable dosing across RCTs (max dose, 0.2 to 1.6 mcg/kg/hr)
➡️Outcomes variably evaluated & defined - do we need a core outcome set for PICU sedation trials?
➡️Paucity of data in cardiac surgical pop'n - most subgroup analyses could not be performed
➡️12 RCTs, 592 participants
➡️Variable dosing across RCTs (max dose, 0.2 to 1.6 mcg/kg/hr)
➡️Outcomes variably evaluated & defined - do we need a core outcome set for PICU sedation trials?
➡️Paucity of data in cardiac surgical pop'n - most subgroup analyses could not be performed
September 24, 2025 at 8:30 PM
Key findings:
➡️12 RCTs, 592 participants
➡️Variable dosing across RCTs (max dose, 0.2 to 1.6 mcg/kg/hr)
➡️Outcomes variably evaluated & defined - do we need a core outcome set for PICU sedation trials?
➡️Paucity of data in cardiac surgical pop'n - most subgroup analyses could not be performed
➡️12 RCTs, 592 participants
➡️Variable dosing across RCTs (max dose, 0.2 to 1.6 mcg/kg/hr)
➡️Outcomes variably evaluated & defined - do we need a core outcome set for PICU sedation trials?
➡️Paucity of data in cardiac surgical pop'n - most subgroup analyses could not be performed