Zachary McCaw
@zmccaw.bsky.social
Biostatistician and machine learning scientist
It's unfortunately not a general solution to this problem. LOCO-PGS can adjust for genetic common causes of the heritable covariate and the phenotype (e.g. SNPs on other chromosomes), but it cannot adjust for environmental common causes (e.g. diet).
February 12, 2025 at 3:52 AM
It's unfortunately not a general solution to this problem. LOCO-PGS can adjust for genetic common causes of the heritable covariate and the phenotype (e.g. SNPs on other chromosomes), but it cannot adjust for environmental common causes (e.g. diet).