T Cell Immunology - WANG LAB
@zimmorn.bsky.social
We are focusing on T cell biology, CAR-T/TCR-T therapies, immune checkpoints like LAG3, and Treg function regulation. We aim to advance cancer and autoimmune immunotherapy through cutting-edge research and innovation.
🔓 New #CellPreview by Prof. Kai W. Wucherpfennig @harvard.edu highlights our work on LAG3!
Key take:
• Cbl-mediated, non-degradative poly-ubiquitination at K498 unlocks LAG3 signaling
• Marks TILs that respond to PD-1/LAG3 combo
#LAG3 #Immunotherapy #PD1 #TCell
www.cell.com/cell/fulltex...
Key take:
• Cbl-mediated, non-degradative poly-ubiquitination at K498 unlocks LAG3 signaling
• Marks TILs that respond to PD-1/LAG3 combo
#LAG3 #Immunotherapy #PD1 #TCell
www.cell.com/cell/fulltex...
Unlocking LAG3: Ubiquitin’s unexpected role
The inhibitory receptor LAG3 is the target of the FDA-approved mAb relatlimab, but
its mechanism of signaling is not well understood. In this issue of Cell, Jiang et al.
demonstrate that ubiquitinatio...
www.cell.com
May 2, 2025 at 2:08 AM
🔓 New #CellPreview by Prof. Kai W. Wucherpfennig @harvard.edu highlights our work on LAG3!
Key take:
• Cbl-mediated, non-degradative poly-ubiquitination at K498 unlocks LAG3 signaling
• Marks TILs that respond to PD-1/LAG3 combo
#LAG3 #Immunotherapy #PD1 #TCell
www.cell.com/cell/fulltex...
Key take:
• Cbl-mediated, non-degradative poly-ubiquitination at K498 unlocks LAG3 signaling
• Marks TILs that respond to PD-1/LAG3 combo
#LAG3 #Immunotherapy #PD1 #TCell
www.cell.com/cell/fulltex...
Reposted by T Cell Immunology - WANG LAB
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function. Recent study found ubiquitination of LAG3 promotes its inhibitory function rather than its degradation, and is required for suppression of antitumor immunity in vivo. ow.ly/xOKh50VkhNt 🧪
March 21, 2025 at 2:20 PM
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function. Recent study found ubiquitination of LAG3 promotes its inhibitory function rather than its degradation, and is required for suppression of antitumor immunity in vivo. ow.ly/xOKh50VkhNt 🧪
Our team is thrilled to announce the publication of our latest study "Ligand-Induced Ubiquitination Unleashes LAG3 Immune Checkpoint Function" in 𝐂𝐞𝐥𝐥! This work unveils a molecular switch controlling LAG3 activation and paves the way for precision immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs
This study uncovers the molecular mechanism of LAG3 activation upon ligand engagement
and its regulation by non-degradative polyubiquitination within the tumor microenvironment.
The findings highlight...
www.cell.com
March 22, 2025 at 1:46 AM
Our team is thrilled to announce the publication of our latest study "Ligand-Induced Ubiquitination Unleashes LAG3 Immune Checkpoint Function" in 𝐂𝐞𝐥𝐥! This work unveils a molecular switch controlling LAG3 activation and paves the way for precision immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...