Zhilin Zhang (张智霖)
zhilinzhang94.bsky.social
Zhilin Zhang (张智霖)
@zhilinzhang94.bsky.social
Ph.D. Student working on bioinformatics, Plant Epigenomics, Epimutation rate, at TUM
Reposted by Zhilin Zhang (张智霖)
A second paper followed in 2023 using epigenetic rather than genomic data from some of our lines, this time from our collaboration with Frank Johannes and his lab:

www.science.org/doi/10.1126/...
An evolutionary epigenetic clock in plants
A fast-ticking evolutionary epigenetic clock in plants facilitates phylogenetic insights into the recent past.
www.science.org
June 6, 2025 at 3:45 PM
Reposted by Zhilin Zhang (张智霖)
Very excited to finally share the main findings from my PhD, now out as a preprint!

We developed an epigenetic system to understand how plants remember and forget past infections - a phenomenon known as immune memory 🌱🧬🧠

Highlights below! 1/9

www.biorxiv.org/content/10.1...
From recall to reset: the role of DNA (de)methylation in modulating plant immune memory
Epigenetic reprogramming is increasingly recognised as a driver of plant immune memory, yet its molecular basis remains poorly understood. Using a chemically inducible transgene in Arabidopsis, we tra...
www.biorxiv.org
August 19, 2025 at 8:02 PM
Reposted by Zhilin Zhang (张智霖)
Happy to share the results of a long-haul post-doc project, now online @science.org, aiming at understanding the rules of transgeneration epigenetic inheritance over TEs in plants and its extent and impact in nature. More below!
doi.org/10.1126/scie...
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
doi.org
September 18, 2025 at 6:35 PM
Reposted by Zhilin Zhang (张智霖)
Out after peer review, collaborative study from Nordborg & Weigel labs with help from many others. Not the largest collection of new Arabidopsis thaliana genomes, but we hopefully put forward some good ideas for how to think about pangenomes and their analysis!
www.nature.com/articles/s41...
August 20, 2025 at 6:23 AM
Reposted by Zhilin Zhang (张智霖)
In 2024, the main paper from our collaboration with Frank's group appeared on BioRxiv:

www.biorxiv.org/content/10.1...

With this week's BioRxiv submission, that's four exciting papers from what was, in some respects, a failed experiment.
Multi-generational biotic stress increases the rate of spontaneous epimutations in a ROS1-dependent manner
Mistakes in the maintenance of CG methylation are a source of spontaneous epimutations in plants that can be inherited across generations. The extent to which these stochastic events are affected by p...
www.biorxiv.org
June 6, 2025 at 3:45 PM
Reposted by Zhilin Zhang (张智霖)
Some really nice work from the Schmitz and Johannes labs. A small deletion adjacent to a couple of genes involved in DNA methylation maintenance has lead to a divergence in DNA methylation patterns in an Arabidopsis ecotype from the Cape Verde Islands.
www.biorxiv.org
June 16, 2025 at 2:53 PM