And for anyone that wants a preview, have a watch of @crick.ac.uk most watched video on TikTok where @danafd.bsky.social shares more about her shark work vm.tiktok.com/ZNdcRfrNd/ 🦈🔥

Watch this space for some beautiful forebrain data across beasts and species 🦈🐭🐣

Happy birthday Rita!

Thanks Flor :)

Kudos to Alicia Donoghue from the Fernandes lab for the beautiful experiments, our own Lewis Mosby who was behind most of the theoretical work and everyone involved, it's been such fun putting the pieces together for this one. Would love to hear feedback!

So juxtacrine and temporally dynamic signals can themselves carry and refine positional information, augmenting that provided by morphogens to enable robust, fine-grained patterning.

This is all orchestrated by Glia morphogenesis: wrapping glia act as timekeepers, ensuring that cells differentiate after Hh and Notch patterns are established in each lamina column.

But the relationship between Hh and Notch goes beyond that: Notch restricts Hh expression in lamina cells, which results in the first, and only the first, cell in each column in the lamina expressing Hh, and does so at the right time.

It turns out that the Hh gradient is not sufficient on its own to specify all neuronal fates (also see elifesciences.org/articles/78093). Instead, we show that the combination of Notch and Hh activities together determine what neuron a cell is destined to be