Zeb Levine
@zebulonlevine.bsky.social
Chemical Biologist- postdoc with @jswlab.bsky.social, former PhD Suzanne Walker at HMS, studying quality control. Rock climber and dog dad
Reposted by Zeb Levine
I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.
August 27, 2025 at 9:44 PM
I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.
Reposted by Zeb Levine
Here is a quick thread to promote my research! After years of dedicated research, I'm thrilled to share our article just published at Nature Communications :)
www.nature.com/articles/s41...
#metabolism #CRISPRscreens #mitochondria
www.nature.com/articles/s41...
#metabolism #CRISPRscreens #mitochondria
SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation
Nature Communications - Pyridoxal 5’-phosphate (PLP, vitamin B6) is crucial for various metabolic processes. Here, the authors identified SLC25A38 as a key regulator of mitochondrial PLP...
www.nature.com
January 25, 2025 at 12:29 PM
Here is a quick thread to promote my research! After years of dedicated research, I'm thrilled to share our article just published at Nature Communications :)
www.nature.com/articles/s41...
#metabolism #CRISPRscreens #mitochondria
www.nature.com/articles/s41...
#metabolism #CRISPRscreens #mitochondria
Reposted by Zeb Levine
How proximal is proximity labeling❓ Using DNA nanorulers we found that TurboID/BioID are largely contact labeling, while APEX2 also bears a major contact labeling pathway in parallel with diffusive labeling.
www.biorxiv.org/content/10.1...
Special thanks to @aliceyting.bsky.social for discussions
www.biorxiv.org/content/10.1...
Special thanks to @aliceyting.bsky.social for discussions
December 19, 2024 at 2:22 AM
How proximal is proximity labeling❓ Using DNA nanorulers we found that TurboID/BioID are largely contact labeling, while APEX2 also bears a major contact labeling pathway in parallel with diffusive labeling.
www.biorxiv.org/content/10.1...
Special thanks to @aliceyting.bsky.social for discussions
www.biorxiv.org/content/10.1...
Special thanks to @aliceyting.bsky.social for discussions
Reposted by Zeb Levine
In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
www.biorxiv.org/content/10.1...
Check it out!
www.biorxiv.org/content/10.1...
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...
www.biorxiv.org
November 21, 2024 at 6:24 PM
In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
www.biorxiv.org/content/10.1...
Check it out!
www.biorxiv.org/content/10.1...