🧠 Sedation in the ICU: are volatile anesthetics better than IV anesthetics?

Our meta-analysis of 21 RCTs (n=2,367): volatile sedation ↑ mortality (RR 1.17 [1.02–1.35]) vs. IV Sedation

⚠️ Routine use is not supported. Consider only in selected patients.

🔗 ccforum.biomedcentral.com/articles/10....

Heterogeneity in the therapeutic effects of oxygen therapy in critically ill patients

Different baseline conditions, acute diseases, and concurrent interventions likely modify the optimal goals for oxygen therapy. Two large RCTs may guide future practice.
ccforum.biomedcentral.com/articles/10....

Last publication in 2024🍾
We assessed the effects of non-adrenergic vasopressors in three populations (sepsis, cardiac surgery, and non-cardiac surgery).
Our findings justify future RCTs comparing these agents with usual care based on noradrenaline alone.
ccforum.biomedcentral.com/articles/10....

Scoping review of persistent/chronic critical illness
- varied terminology & definitions
- prevalent, especially in sepsis, COVID-19, & trauma
- poor long-term mortality and functional outcomes
- need for the development of a consensus definition
ccforum.biomedcentral.com/articles/10....

A multicenter RCT published in BMJ reported that fluid & inotropic management guided by cardiac output in abdominal surgeries (ASA II or higher) did not reduce postoperative infections but led to an increase in cardiac events within 24 h, particularly tachyarrhythmias.
www.bmj.com/content/387/...

Core Outcome Set for Physical Rehabilitation in Critically Ill Patients
🔸Physical function
🔸Exercise capacity
🔸ADL
🔸Cognitive function
🔸Survival
🔸Emotional and mental well-being
🔸Frailty
🔸Health-related quality of life
🔓 www.atsjournals.org/doi/10.1513/...

New publication: Role of RAAS and Exogenous Angiotensin II Therapy in Sepsis

We review RAAS alterations in sepsis, summarize the evidence for IV angiotensin II administration, and propose a practical algorithm for its use.
Honor to collaborate with global experts in this field!
x.gd/Yio8K

Energy and Protein Intake for Critically Ill Patients

High energy: Worsening organ dysfunction
High protein: Increased mortality in AKI
Prolonged undernutrition: Poor functional recovery
A proposed algorithm to determine energy and protein intake based on the severity and ICU days.
bit.ly/4eMfOj6