YuGeng Zhang
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yugibear.bsky.social
YuGeng Zhang
@yugibear.bsky.social
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DPhil student in the Tang lab - Dunn School of Pathology, Oxford. Bacterial defence islands and their regulation.
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asaflevylab.bsky.social
Expression level of anti-phage defence systems controls a trade-off between protection range and autoimmunity
By Nitzan Aframian and Avigdor Eldar.
www.nature.com/articles/s41...
Expression level of anti-phage defence systems controls a trade-off between protection range and autoimmunity - Nature Microbiology
The authors examine several defense systems and find that increased expression enhances their protection range, albeit at a cost of autoimmunity.
www.nature.com
July 26, 2025 at 6:59 AM
yugibear.bsky.social
Thrilled to see our paper out now in @narjournal.bsky.social: a new transcriptional repressor, RptR, that regulates type I restriction-modification systems! 🎉

Big thanks to the Tang lab (Chris Tang, Rachel Exley), @schullerm.bsky.social, @ahellab.bsky.social and Tim Blower!

doi.org/10.1093/nar/...
Regulation of a phage defence island by RptR, a novel repressor that controls restriction–modification systems in diverse bacteria
Abstract. Bacteria encode a panoply of defence systems to overcome phage infection. In recent years, over 100 defence systems have been identified, with th
doi.org
July 14, 2025 at 1:55 PM