Yousuf A. Khan
@yousufakhan.bsky.social
Group Leader @Stanford. RNA focused ML/AI, cryoEM/ET, and biophysics. Formerly:DeepMind AlphaFold,EvoscaleAI, Churchill Scholar@Cambridge_Uni & seen on Netflix
Sharing some of my PhD work that just came out today.
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
July 2, 2025 at 9:24 PM
Sharing some of my PhD work that just came out today.
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
TLDR; We found a universal mechanism for all the many kinds of SNAREs are processed and recycled by a single molecular machine that is conserved in all eukaryotic life as we know it (1/5)
www.nature.com/articles/s41...
(1/5)
A proper intro: I'm at Stanford currently and I study (3) things 🧪
1) #cryoEM and #cryoET #teamtomo
of molecular machines: We put out a preprint on how the AAA+ machine Sec18 bypasses topology of all SNARE substrates by using 'side-release' and 'side-loading' (www.biorxiv.org/content/10.1...)
1/3
1) #cryoEM and #cryoET #teamtomo
of molecular machines: We put out a preprint on how the AAA+ machine Sec18 bypasses topology of all SNARE substrates by using 'side-release' and 'side-loading' (www.biorxiv.org/content/10.1...)
1/3
November 15, 2024 at 2:25 AM
A proper intro: I'm at Stanford currently and I study (3) things 🧪
1) #cryoEM and #cryoET #teamtomo
of molecular machines: We put out a preprint on how the AAA+ machine Sec18 bypasses topology of all SNARE substrates by using 'side-release' and 'side-loading' (www.biorxiv.org/content/10.1...)
1/3
1) #cryoEM and #cryoET #teamtomo
of molecular machines: We put out a preprint on how the AAA+ machine Sec18 bypasses topology of all SNARE substrates by using 'side-release' and 'side-loading' (www.biorxiv.org/content/10.1...)
1/3
1) We recently put out a preprint about how the AAA+ machine Sec18/NSF (www.biorxiv.org/content/10.1...) are able to load every and any SNARE substrate in the cell by bypassing their N- and C-terminal domains completely by employing a mechanism we've coined 'side-loading' and 'side-release'
(2/4)
(2/4)
November 14, 2024 at 11:20 PM
1) We recently put out a preprint about how the AAA+ machine Sec18/NSF (www.biorxiv.org/content/10.1...) are able to load every and any SNARE substrate in the cell by bypassing their N- and C-terminal domains completely by employing a mechanism we've coined 'side-loading' and 'side-release'
(2/4)
(2/4)