Youran R Zhang
@youranrzhang.bsky.social
MD/PhD candidate at Tsinghua University, combining compassion and innovation in medicine.
📍Singapore
📍Singapore
Scratching exacerbates skin inflammation and enhances host defense against S. Aureus. And of course it’s all because of mast cells. Check out the new paper by Andrew Liu in the Kaplan lab. www.science.org/doi/10.1126/...
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...
www.science.org
January 31, 2025 at 12:54 AM
Scratching exacerbates skin inflammation and enhances host defense against S. Aureus. And of course it’s all because of mast cells. Check out the new paper by Andrew Liu in the Kaplan lab. www.science.org/doi/10.1126/...
Thrilled to share my work at Science Translational Medicine! Glutamate receptor GluK2 is enriched in mast cells. Small molecule agonism suppresses mast cell response to MrgprB2/X2 ligands and reduces inflammation in murine models of contact dermatitis and rosacea www.science.org/doi/10.1126/...
Agonism of the glutamate receptor GluK2 suppresses dermal mast cell activation and cutaneous inflammation
Small-molecule agonism of GluK2 reduces dermal mast cell responses to MrgprB2 ligation and suppresses skin inflammation.
www.science.org
December 12, 2024 at 11:08 AM
Thrilled to share my work at Science Translational Medicine! Glutamate receptor GluK2 is enriched in mast cells. Small molecule agonism suppresses mast cell response to MrgprB2/X2 ligands and reduces inflammation in murine models of contact dermatitis and rosacea www.science.org/doi/10.1126/...