yorickgrift.bsky.social
@yorickgrift.bsky.social
Post-Doc in the Cantù lab 🇳🇱 🇸🇪 || Genomics || Organoids || WNT signalling || Cancer || Development
Reposted by yorickgrift.bsky.social
In one tumor, despite the shared oncogenic driver mutations, there may be different cell types
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
Differential Wnt/β-Catenin Signaling via TCF7L2/LEF1 Binding Specificity Shapes Cellular and Tumor Phenotypes https://www.biorxiv.org/content/10.1101/2025.11.04.686471v1
November 10, 2025 at 10:04 AM
In one tumor, despite the shared oncogenic driver mutations, there may be different cell types
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
In collaboration with the Peng Lab we used Hepatoblastoma to investigate this.
Our results show that β-catenin can drive different transcriptional programs across cancer cell populations
Check this out👇
Reposted by yorickgrift.bsky.social
We are hiring! 2 years postdoctoral fellowship, to work on the generation of all-human, vascularized and innervated organ-on-chip systems & model infection & inflammation - in Sweden 🇸🇪 @liu.se
Details in the link - please help me spreading the announcement!
liu.se/en/organisat...
Details in the link - please help me spreading the announcement!
liu.se/en/organisat...
Open positions in bioengineering
Learn more about open scholarship positions in bioengineering at IFM.
liu.se
September 3, 2025 at 3:01 PM
We are hiring! 2 years postdoctoral fellowship, to work on the generation of all-human, vascularized and innervated organ-on-chip systems & model infection & inflammation - in Sweden 🇸🇪 @liu.se
Details in the link - please help me spreading the announcement!
liu.se/en/organisat...
Details in the link - please help me spreading the announcement!
liu.se/en/organisat...
Reposted by yorickgrift.bsky.social
SOX2 and NR2F1 cooperate
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus
Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.
journals.biologists.com
August 11, 2025 at 12:55 PM
SOX2 and NR2F1 cooperate
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
to make #neurons in the #Thalamus
for visual input from the #retina
#DevBio
journals.biologists.com/bio/article/...
@biologyopen.bsky.social
In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social
Driven by Linda Serra and @annanordin.bsky.social
Reposted by yorickgrift.bsky.social
A 6-year long study from the Lab is finally out @genomeresearch.bsky.social
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
July 15, 2025 at 7:58 AM
A 6-year long study from the Lab is finally out @genomeresearch.bsky.social
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social
Why is our work Important? Discover it in the quick Bluetorial 👇
genome.cshlp.org/content/earl...
Reposted by yorickgrift.bsky.social
A study led by @claudiocantu81.bsky.social show how the protein TBX3, key in early development, resurfaces in aggressive cancers – making them harder to treat.
New insights, new hope for targeted therapies.
🔗 liu.se/en/news-item...
#research #cancer
New insights, new hope for targeted therapies.
🔗 liu.se/en/news-item...
#research #cancer
Mechanism in embryonic development makes cancer aggressive
Tumour cells in colorectal cancer exploit an important signalling pathway that normally controls embryo development. Researchers have now shown how a protein that controls limb development make colore...
liu.se
May 27, 2025 at 6:28 AM
A study led by @claudiocantu81.bsky.social show how the protein TBX3, key in early development, resurfaces in aggressive cancers – making them harder to treat.
New insights, new hope for targeted therapies.
🔗 liu.se/en/news-item...
#research #cancer
New insights, new hope for targeted therapies.
🔗 liu.se/en/news-item...
#research #cancer
Reposted by yorickgrift.bsky.social
We had previously shown that TBX3 and #WNT cooperate in limb #DevBio
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes
www.pnas.org
May 12, 2025 at 7:33 AM
We had previously shown that TBX3 and #WNT cooperate in limb #DevBio
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
We now have a shocking finding, just published in @pnas.org
TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)
www.pnas.org/doi/epub/10....
Reposted by yorickgrift.bsky.social
Story time! We are excited to share our new Biorxiv pre-print which we hope will also find a home in a peer-reviewed journal soon: "GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers
WNT4 is critical for epithelial side branching in the mammary gland. In both mice and humans, its expression is tightly regulated and restricted to hormone-responsive, mature luminal cells. Although g...
www.biorxiv.org
April 17, 2025 at 3:02 PM
Story time! We are excited to share our new Biorxiv pre-print which we hope will also find a home in a peer-reviewed journal soon: "GRHL and PGR control WNT4 expression in the mammary gland via 3D looping of conserved and species-specific enhancers"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...