Thank you Shahid

Can’t wait to see more TKP–effector pairs conferring resistance to different diseases

Our in planta and in vitro results show that RWT4 directly and specifically binds to AvrPWT4. This interaction requires RWT4’s N-terminal kinase duplication domain, which functions like an integrated domain (ID) seen in some NLR proteins. The binding is essential for RWT4 recognition.

We also showed that RWT4 is an active kinase, and its kinase activity is essential for triggering defense responses.

Wheat TKP RWT4 directly binds to the fungal effector AvrPWT4 to trigger immune responses against the devastating Magnaporthe oryzae. We developed a rice protoplast system to reconstitute RWT4–AvrPWT4 recognition in a monocot background—providing a useful model for future TKP studies.

Can’t wait to see more TKP–effector pairs conferring resistance to different diseases!

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