Ya Yin Chang
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yayinchang.bsky.social
Ya Yin Chang
@yayinchang.bsky.social
Neuroscience PhD Candidate @ Edinburgh Uni & UKDRI, I’m all about synapses & neurodegeneration 🧠 | Scientific editorial team @ Brain Comms!
Impressive talk Tara!! @tspiresjones.bsky.social Wish I could record the audible “wow”s around me when you showed the 3D EM reconstructions. Synapses and all its’ beauty!
November 17, 2025 at 3:16 AM
Good morning from rainy San Diego!! I’m all set up for #SfN2025, bar an umbrella but it’s dry indoors anyway 🤭
November 15, 2025 at 5:07 PM
Reposted by Ya Yin Chang
See a lovely piece on STV highlighting the impacts of this disease on families . While our new findings will not lead to a new treatment today, we aim to bring hope to people living with PSP for the future news.stv.tv/east-central...
'People think my wife is drunk but she's living with a rare brain disease'
Edinburgh couple hope for treatment for rare neurological condition progressive supranuclear palsy.
news.stv.tv
July 17, 2025 at 11:56 AM
Reposted by Ya Yin Chang
Delighted to share our paper examining synaptic tau in PSP. Many thanks to @robertmcgeachan.bsky.social @clairedurrant1.bsky.social and our many collaborators and funders. And extra special thanks to tissue donors who make this work possible.
📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.

Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
July 17, 2025 at 11:54 AM
Reposted by Ya Yin Chang
Our paper in Nature Comms is now online! Summary below but in short we use living human brain slice cultures in a number of different ways to model dementia processes. Big team effort led by myself, @robertmcgeachan.bsky.social and @clairedurrant1.bsky.social rdcu.be/ej647
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Nature Communications - Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or...
rdcu.be
April 30, 2025 at 3:22 PM
Reposted by Ya Yin Chang
Day 3: @braincomms.bsky.social and @brain1878.bsky.social up for the last day, we are waiting for you 😆 #bna2025
April 30, 2025 at 9:10 AM
Day 3 at #BNA2025: At the @brain1878.bsky.social & @braincomms.bsky.social booth in between sessions! 👋🏼
April 30, 2025 at 9:43 AM
Reposted by Ya Yin Chang
@braincomms.bsky.social booth at #BNA2025 is busy come say hi!
April 28, 2025 at 2:41 PM
What a venue!! At the #BNA2025 Gala dinner 😍
April 29, 2025 at 10:19 PM
Reposted by Ya Yin Chang
Another fantastic poster session #BNA2025
April 29, 2025 at 2:46 PM