Hussein N. Yassine
@yassinelab1.bsky.social
Professor of Neurology. Humanist. Mentor. Alzheimer’s disease research.
At human doses? Sorry did not look closely
A problem with many mice studies is doses used are quite exaggerated by design to see an effect.
A problem with many mice studies is doses used are quite exaggerated by design to see an effect.
September 24, 2025 at 10:19 PM
At human doses? Sorry did not look closely
A problem with many mice studies is doses used are quite exaggerated by design to see an effect.
A problem with many mice studies is doses used are quite exaggerated by design to see an effect.
I don’t think anyone paid attention to this paper until now. A meta analysis can be useful if the papers they are citing are credible and the authors follow proper methodology. Without a mechanism, the association of Tylenol with autism is vague. This paper makes us look more deeply into this.
September 24, 2025 at 3:16 PM
I don’t think anyone paid attention to this paper until now. A meta analysis can be useful if the papers they are citing are credible and the authors follow proper methodology. Without a mechanism, the association of Tylenol with autism is vague. This paper makes us look more deeply into this.
Enjoyed your podcast! Appreciated the insights into education and cognition.
September 7, 2025 at 10:13 PM
Enjoyed your podcast! Appreciated the insights into education and cognition.
Very beautiful Meredith!
August 27, 2025 at 4:19 PM
Very beautiful Meredith!
Well said! Science is for all of us and should be above politics.
August 22, 2025 at 6:44 PM
Well said! Science is for all of us and should be above politics.
The system can be gamed
Reviews are highly cited and often self citing the authors work
Unfortunately we all do this
Both journals and authors can inflate their citation indices with paper mills or high IF reviews
The number of citations does not replace a critical appraisal
Reviews are highly cited and often self citing the authors work
Unfortunately we all do this
Both journals and authors can inflate their citation indices with paper mills or high IF reviews
The number of citations does not replace a critical appraisal
July 23, 2025 at 9:00 PM
The system can be gamed
Reviews are highly cited and often self citing the authors work
Unfortunately we all do this
Both journals and authors can inflate their citation indices with paper mills or high IF reviews
The number of citations does not replace a critical appraisal
Reviews are highly cited and often self citing the authors work
Unfortunately we all do this
Both journals and authors can inflate their citation indices with paper mills or high IF reviews
The number of citations does not replace a critical appraisal
Someone who kept citing himself..
July 23, 2025 at 6:54 PM
Someone who kept citing himself..
Letrozole and irinotecan are not typically used for aging-related diseases. These are chemotherapies with severe side effects. While the approach is novel, the results are unconventional to say the least!
July 22, 2025 at 12:00 AM
Letrozole and irinotecan are not typically used for aging-related diseases. These are chemotherapies with severe side effects. While the approach is novel, the results are unconventional to say the least!
Congratulations! There is light at the end of the tunnel
July 16, 2025 at 9:04 PM
Congratulations! There is light at the end of the tunnel
Perhaps the problem as you note is an incomplete understanding of how science works. Selection bias is one, but there are many others. Interpretation of study designs, limitations, conflating causation with associations. This can be fixed if children were exposed to critical thinking early on.
June 1, 2025 at 1:37 PM
Perhaps the problem as you note is an incomplete understanding of how science works. Selection bias is one, but there are many others. Interpretation of study designs, limitations, conflating causation with associations. This can be fixed if children were exposed to critical thinking early on.
We are all in the same boat. We just have to keep going.
February 27, 2025 at 11:05 PM
We are all in the same boat. We just have to keep going.
Any tips? I deleted X…
February 15, 2025 at 8:03 PM
Any tips? I deleted X…
4/4: When we lowered oxysterols using cyclodextrin in vivo, ABCA1 recycled to the plasma membrane, and neuroinflammation was reduced. Accumulation of oxidized cholesterol in lysosomes in APOE4 AD is an important mechanism for senescence. Drugs targeting lysosomal lipids are promising strategies.
February 5, 2025 at 10:47 PM
4/4: When we lowered oxysterols using cyclodextrin in vivo, ABCA1 recycled to the plasma membrane, and neuroinflammation was reduced. Accumulation of oxidized cholesterol in lysosomes in APOE4 AD is an important mechanism for senescence. Drugs targeting lysosomal lipids are promising strategies.
3/4: Proteomic discovery experiments identified the cholesterol sensor, Caveolin-1 as the mechanism for ABCA1 sequestration into lysosomes. The accumulation of oxysterol species in APOE4 induced ABCA1 and trapped it in lysosomes.
February 5, 2025 at 10:43 PM
3/4: Proteomic discovery experiments identified the cholesterol sensor, Caveolin-1 as the mechanism for ABCA1 sequestration into lysosomes. The accumulation of oxysterol species in APOE4 induced ABCA1 and trapped it in lysosomes.