Yash Gupta PhD
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Yash Gupta PhD
@yashul12.bsky.social
45 followers 39 following 1 posts
🧬 Postdoc @PennStateMed | 🦠 Infectious Diseases | 💊 Drug Discovery | 🧫 Microbiome & RNA Therapeutics
📚 40+ Pubs | 🧪 Editor & Reviewer | 🌍 ORCID: 0000-0003-3002-1315
Bridging molecules & medicine. I chase cures with code, cells & curiosity. 🧬🧠
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🚀 New in @SciReports:
Biomimetic ZnO nanorods camouflaged with Caco-2 membranes enable targeted miRNA-200c delivery to gut epithelium.
🔗 doi.org/10.1038/s415...
#MicroRNA #Nanomedicine #IBD #DrugDelivery #Biomaterials #GutHealth #RNAtherapeutics #Nanoparticles #GIbarrier #PrecisionMedicine
This study presents a novel biomimetic nanoparticle platform—Caco-2 cell membrane-coated, manganese-doped ZnO nanorods—for targeted microRNA (miR-200c-3p) delivery to intestinal epithelial cells. By combining magnetic responsiveness, homotypic targeting, and lipid membrane camouflage, the engineered nanoparticles achieve site-specific delivery, enhance intestinal permeability, and modulate tight junction integrity without inducing toxicity. The work demonstrates, for the first time, that: miRNA-loaded nanorods can be guided magnetically and penetrate the mucus barrier. Homotypic targeting using epithelial cell membranes improves localization and uptake. miR-200c delivery via this platform significantly alters occludin expression and gut permeability in vivo. This approach opens new avenues for precision therapeutics in IBD and barrier dysfunction disorders, offering a biocompatible, traceable, and customizable delivery system for gut-targeted RNA therapies.
August 28, 2025 at 11:16 PM