Yes 😁 here is a link to the bsky thread 🧵 bsky.app/profile/xpie...

And here the rotating version of the image (1b/7)

So, it turns out that the mouse visual cortex has a columnar organization for ocular dominance! But what might be the function of such columns in general? We hope that our work inspires further investigation of the molecular, circuits and behavioral aspects of that question. (7/7)

What else? Well, in larger mammals, the spatial arrangement of ocular dominance is related to the retinotopic and other feature maps. Interestingly, in mice we could not detect such relationships. (6/7)

Moreover, the clusters we identified in layer 4 extended vertically into layers 2/3 and 5, forming a columnar organization. (5/7)

We identified the location of these ipsi-patches using a clustering algorithm. But did the data just “type out Shakespeare” by chance? No, neither randomized nor simulated data showed similar spatial distributions for ocular dominance. (4/7)

As expected, there was a retinotopic map, but to our surprise, when we inspected the ‘visual response maps’ we also observed clear patches with mostly ipsilateral eye driven responses in layer 4. (3/7)

How did we find them? Using 2-photon microscopy, we mapped functional properties like retinotopy, orientation tuning, and ocular dominance across a large part of the mouse visual cortex. (2/7)