Wouter van Snippenburg
@wvansnippenburg.bsky.social
Is it accurate though? Sodium is only a minor contributor to the mass of the drug, e.g. 1 gram of ampicillin contains 62 mg sodium = 2.7 mmol. So there's only a sodium problem if you dissolve it in high volume of NaCl 0,9%, which isn't necessary (at least not for amoxi/flucloxacillin which I use).
December 8, 2025 at 9:15 PM
Is it accurate though? Sodium is only a minor contributor to the mass of the drug, e.g. 1 gram of ampicillin contains 62 mg sodium = 2.7 mmol. So there's only a sodium problem if you dissolve it in high volume of NaCl 0,9%, which isn't necessary (at least not for amoxi/flucloxacillin which I use).
July 24, 2025 at 1:23 PM
The formula can be simplified to 5 mL/kg NaCl 3% which will result in an expected increase of about 3 mM in men and about 4 mM in women. Or 0,5 mL/kg NaCl 23.4% again for an expected 3 mM increase in men and 4 mM in women. Holds quite well for starting [Na] 110-150 mM and easy to calculate.
June 24, 2025 at 7:42 PM
The formula can be simplified to 5 mL/kg NaCl 3% which will result in an expected increase of about 3 mM in men and about 4 mM in women. Or 0,5 mL/kg NaCl 23.4% again for an expected 3 mM increase in men and 4 mM in women. Holds quite well for starting [Na] 110-150 mM and easy to calculate.
In my experience i.v. does lower the blood pressure quite well without causing a significant drop in heart rate. So I'm surprised by this. What's your experience? Maybe the composition varies by manufacturer?
May 12, 2025 at 12:55 PM
In my experience i.v. does lower the blood pressure quite well without causing a significant drop in heart rate. So I'm surprised by this. What's your experience? Maybe the composition varies by manufacturer?