Congratulations, beautiful work André!

Great to see this work published in the ACS Chemical Biology special issue Lipids and Lipidation, edited by Jeremy Baskin @jeremybaskin.bsky.social and Bryan Dickinson @chembiobryan.bsky.social. (5/5)

With the photo-controllable version of dual SLIPT (dual SLIPTNVOC) we successfully prove the usefulness of the lipidomimetic for the manipulation of cellular processes in the spatiotemporal control of lamellipodia formation. (4/5)

The project was mainly fueled by the passion and enthusiasm of first author Kristina Bayer. In her work Kristina demonstrates the iterative optimization of dual SLIPT for efficiently recruiting proteins for dimerization on the inner leaflet of the PM in a light controlled, sequential manner. (3/5)

Based on Tsukiji’s SLIPT @shinyatsukiji.bsky.social technology we developed dual-SLIPT as a lipid mimic for defined, sequential protein dimerization on the inner leaflet of the plasma membrane. (2/5)

Congratulations to the first author Philipp Pöschko, master student Caroline Berrou and all co-authors. Special thanks also to Kaisa Pakari and Jochen Wittbrodt for the wonderful collaboration. I am very grateful for the enthusiasm and commitment of everyone involved!