Walther Mothes
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wmothes.bsky.social
Walther Mothes
@wmothes.bsky.social
310 followers 420 following 27 posts
Virologist, Yale University
https://medicine.yale.edu/lab/mothes/
Opinions are my own.
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wmothes.bsky.social
www.trystcraft.com/single-post/...
Tour of the Architecture of Minoru Yamasaki at Wayne State University
All About Architect Minoru Yamasaki The Seattle born and educated Yamasaki moved to Detroit in 1945. By 1949, the young architect had started his own architectural practice in the city. Among other no...
www.trystcraft.com
July 17, 2025 at 4:54 AM
wmothes.bsky.social
Thanks! Thanks to Shan-Lu Liu for featuring this! We like to get back into.
July 16, 2025 at 9:37 PM
wmothes.bsky.social
strokes can change the personality
July 1, 2025 at 4:52 PM
wmothes.bsky.social
the moment you use BPL, you aggregate Spike and trigger post fusion conformation, which is not what you want
May 2, 2025 at 5:57 PM
wmothes.bsky.social
This is the first “vetted” announcement and it speaks of incompetence and corruption
May 2, 2025 at 3:04 PM
wmothes.bsky.social
bad idea to make vaccines against SARS-CoV-2 and RSV with BPL. Post fusion is the wrong conformational state. Then you get non-neutralizing antibodies too that have more side effects, can enhance infection. Maybe flu is better
May 2, 2025 at 2:58 PM
wmothes.bsky.social
Beta-propiolactone (BPL) inactivated virus is no "gold-standard" vaccine. BPL inactivated SARS-CoV-2 causes aggregation and its Spike protein is largely in the post fusion. This will not give you a good vaccine. It is scary how incompetent this is
May 2, 2025 at 5:20 AM
wmothes.bsky.social
pmc.ncbi.nlm.nih.gov/articles/PMC...
Inactivation of SARS-CoV-2 by β-propiolactone causes aggregation of viral particles and loss of antigenic potential
Inactivated viral preparations are important resources in vaccine and antisera industry. Of the many vaccines that are being developed against COVID-19, inactivated whole-virus vaccines are also consi...
pmc.ncbi.nlm.nih.gov
May 2, 2025 at 3:44 AM
wmothes.bsky.social
www.pnas.org/doi/10.1073/...
Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein | PNAS
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mediates membrane fusion to allow entry of the viral genome into ...
www.pnas.org
May 2, 2025 at 3:41 AM
wmothes.bsky.social
"... American institutions of higher learning have in common the essential freedom to determine, on academic grounds, whom to admit and what is taught, how, and by whom." 2/2
April 22, 2025 at 2:53 PM