wilsonwu1.bsky.social
@wilsonwu1.bsky.social
Reposted
More mechanistic details on the hyperglucagonemia observed following gcgr knockout. Convincing role for VGF protein in glucagon secretion #EndocrineSky

www.nature.com/articles/s41...
Blockade of glucagon receptor induces α-cell hypersecretion by hyperaminoacidemia in mice - Nature Communications
The glucagon receptor (GCGR) antagonism is a potential target for diabetes therapy but side effects such as α-cell hyperplasia and hyperglucagonemia limit therapeutic development. Here the authors rep...
www.nature.com
March 29, 2025 at 12:39 PM