William Werbel, MD PhD
@williamwerbel.bsky.social
Transplant/oncology infectious diseases @ Johns Hopkins. Personalized prevention of serious infections (eg, 💉 vs viruses). Advancing intersection of HIV & transplantation (#HOPEinAction). Views=me. https://emergingpathogens.jhmi.edu
Not for 5-10 years. Ribavirin, yes.
September 24, 2025 at 12:44 AM
Not for 5-10 years. Ribavirin, yes.
Note: NOT concern for 1) adult & pregnant person vax, 2) nirsevimab [great/safe to reduce RSV disease]
Rather, & prefer not to speculate, Q if incompletely-achieved immunity in babies 6-12m (maternal immunity wane + not yet had full 3-dose vax series) might have some inc. aberrant response risk
Rather, & prefer not to speculate, Q if incompletely-achieved immunity in babies 6-12m (maternal immunity wane + not yet had full 3-dose vax series) might have some inc. aberrant response risk
December 12, 2024 at 5:33 PM
Note: NOT concern for 1) adult & pregnant person vax, 2) nirsevimab [great/safe to reduce RSV disease]
Rather, & prefer not to speculate, Q if incompletely-achieved immunity in babies 6-12m (maternal immunity wane + not yet had full 3-dose vax series) might have some inc. aberrant response risk
Rather, & prefer not to speculate, Q if incompletely-achieved immunity in babies 6-12m (maternal immunity wane + not yet had full 3-dose vax series) might have some inc. aberrant response risk
There is some N1 antibody cross reactivity (eg, pmc.ncbi.nlm.nih.gov/articles/PMC...), again significance uncertain when talking about current strain and real life infections. But, would hope better than nil!
Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09
We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In c...
pmc.ncbi.nlm.nih.gov
December 7, 2024 at 8:11 PM
There is some N1 antibody cross reactivity (eg, pmc.ncbi.nlm.nih.gov/articles/PMC...), again significance uncertain when talking about current strain and real life infections. But, would hope better than nil!
Will have to be proven, but I might disagree with “useless” if we are talking about some protection against severe H5N1 disease owing to potential H1N1 cross immunity (eg, T cell stuff). Prevention of infection? Agree.
December 7, 2024 at 8:08 PM
Will have to be proven, but I might disagree with “useless” if we are talking about some protection against severe H5N1 disease owing to potential H1N1 cross immunity (eg, T cell stuff). Prevention of infection? Agree.