Incredibly pleased to have been awarded a BIOREME Starter Grant! I'll be visiting the Statistical Biophysics lab at École Normale Supérieure in Paris to learn about probabilistic modelling of T cell receptor generation. I'll also be visiting as many local patisseries as possible.

Skimmed this and looks an incredible piece of work. Looking forward to digging into it a little more. Nicely done!

Even if the trial is negative, the real primary outcome was the friends you made along the way

Hopping into a canoe and paddling up the train tracks to Westminster for the BTS Winter Meeting

T cell receptor sharing in hypersensitivity pneumonitis https://www.biorxiv.org/content/10.1101/2024.11.13.623392v1

New preprint! We think it's possible to use TCR repertoire profiling to identify antigens in hypersensitivity pneumonitis. If two individuals with HP share disease-related TCRs, knowing one patient's HP antigen means you also know the other's.
www.biorxiv.org/content/10.1...

Back on here, I think. As good a time as any to mention that I'm giving a talk on ageing and pulmonary inflammation at the BTS Winter Conference in a couple of weeks... Maybe need to make the slides at some point

Editor-in-Training at the Blue Journal? Don't mind if I do

I don't think it's right to have a grant application window that opens in late November and closes at the end of January

Fewer than 24 hours until I have a chance to walk into a big building and make a fool of myself in front of some very important people

I have only ever met one person who has been able to convince me that they understand the kidney

Editor-in-chief sending me more manuscripts to send out for review when I'm already fighting for my life trying to find reviewers for the ones I had before

I would struggle to do this now with ggplot2

Only just skimmed this today but looks a phenomenal paper: gain-of-function mutation identified in a muscle hypertrophy syndrome, reproduced in a mouse model, treated in mice with inhibitor, then treated in patients successfully. Looking forward to reading properly.

rupress.org/jem/article-...

I'm Wezi, a doctor specialising in respiratory medicine in Newcastle with a clinical interest in interstitial lung diseases. I'm also a postdoc at Newcastle University, and I have research interests in the innate and adaptive immune responses of the lung to antigen inhalation. #HiSciSky

Great #PCCM MDT today. Haematologists and clinical immunologists brought along some cases of theirs to discuss: patients developing interstitial lung abnormalities secondary to CVID or after bone marrow transplant. Challenging cases, huge opportunity to learn how to do the best for these patients.

Late to the party, but the Jupyter extension for VS Code is a sanity-saver

Getting a feel for how Bluesky works while I hamfistedly work through some data processing, extracting T cell receptor sequences from publicly available scRNAseq datasets. Sounds boring but potentially very interesting if I can prove a hypothesis I have...