Weston Anderson
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Weston Anderson
@weston-writes.bsky.social
Science communicator | Helping researchers tell stories that matter | Demystifying science by day, rolling crits by night 🎲✨
One sentence summary: A documentary crew follows a group of vampire guys around as they navigate the ups and downs of male friendship.

It's pretty cute. I give it a vampires vs. werewolves out of ten. #filmsky
October 6, 2025 at 4:24 AM
By the way, this #spooktober movie calender prints out pretty nice on tabloid paper. #watchlist #filmsky
October 5, 2025 at 3:02 PM
This movie was a wild ride. Rarely has a film made me feel so uncomfortable.

One sentence summary: A mysterious killer sadistically kills off abusive adults and kid bullies at a summer camp.

I give it queer revenge fantasy?! Out of ten. #filmsky
October 5, 2025 at 4:41 AM
October 4, 2025 at 2:29 AM
One sentence summary: After a disfiguring car accident, a young women endures multiple surgeries under the care of her physician father in his deranged quest to make her beautiful again.

Full of striking imagery that sticks with you. I give it an uncanny silicone mask out of 10 👁👄👁 #filmsky
October 4, 2025 at 2:03 AM
Thank you for adding this context! 😁 It's so important to talk about the limitations of research. I should mention that the human studies from this lab come from populations of mostly urban white women in America. So, the findings can't necessarily be generalized to the global population.
October 3, 2025 at 10:22 PM
These are gorgeous 😍
October 3, 2025 at 10:13 PM
🧪All the research I shared with you today comes from the laboratory of Pepper Schedin. I had the pleasure of working in the Schedin lab for ~4 years. Check out this link to learn more about their amazing work: www.ohsu.edu/school-of-me...
Schedin Lab | OHSU
www.ohsu.edu
October 3, 2025 at 8:42 PM
I know I said I was going to cover changes in the liver, but I think that will have to wait for a future thread. This one has already gotten rather long 😅
October 3, 2025 at 8:39 PM
🧪This type of research matters! When we understand more about how breast cancer starts, we learn more about how to prevent it.
October 3, 2025 at 8:38 PM
🧪So, if you are pregnant should you take ibuprofen to prevent breast cancer? It is too soon to say. There haven't been any clinical trials showing this type of prevention is safe and effective. But the research is encouraging!
October 3, 2025 at 8:36 PM
🧪This suggests that it's possible to prevent breast cancers that occur after pregnancy with short-term, low-dose ibuprofen (Advil)! This is an amazing finding because ibuprofen is already approved as safe in pregnant and breast-feeding women.
October 3, 2025 at 8:34 PM
🧪In rodents, low-dose ibuprophen (generic Advil) can reverse the tumor-promotional inflammation that happens after weaning. And, all without causing negative side effects!
jitc.bmj.com/content/6/1/98
Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer
Background Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical variables known to impact d...
jitc.bmj.com
October 3, 2025 at 8:25 PM
🧪So, weaning after pregnancy causes inflammation in the breast that can promote cancer risk. What do we do about it? The research is still in early stages, but scientists believe that a lot of cancers related to pregnancy and weaning could be prevented.
October 3, 2025 at 8:15 PM
🧪Okay, but here is our eureka moment! One reason why breast cancer risk spikes in the first 5-10 years after childbirth is that inflammation after weaning can promote cancer growth and aggressiveness!
October 3, 2025 at 7:28 PM
🧪It turns out all this immune activity (inflammation) in the breast after weaning isn't great news for breast cancer. Evidence from rodent models shows that weaning-induced involution can promote cancer cells to be more aggressive: pubmed.ncbi.nlm.nih.gov/16436674/
Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis - PubMed
The mammary gland microenvironment during postlactational involution shares similarities with inflammation, including high matrix metalloproteinase activity, fibrillar collagen deposition, and release...
pubmed.ncbi.nlm.nih.gov
October 3, 2025 at 7:22 PM
🧪Here is a nifty little figure showing all these killer immune cells in rodent breast tissue. All those reddish brown spots are immune cells. We see them in rodents after they wean (involution) not in virgin rodents.
October 3, 2025 at 7:02 PM
🧪This process is called "weaning-induced mammary gland involution" and it is metal af. All those milk-producing cells aren't needed anymore, so the immune system swoops in and kills them off. It is a dramatic but totally normal process that also happens to be extremely inflammatory.
October 3, 2025 at 6:55 PM
🧪This process where the breast tissue returns to a non-milk-producing state after weaning is called "weaning induced involution". You can read more about this process in humans in this article: rdcu.be/eJmPU
Characterization of weaning-induced breast involution in women: implications for young women’s breast cancer
npj Breast Cancer - Characterization of weaning-induced breast involution in women: implications for young women’s breast cancer
rdcu.be
October 3, 2025 at 6:44 PM
🧪After weaning, all those new milk-producing cells aren't needed anymore. So, the breast changes again. You can see this change starting at 1-month post-wean: almost all those white spaces full of milk are gone. By 12-months, the breast looks like it did before pregnancy.
October 3, 2025 at 6:39 PM